The TLR2 and TLR4 gene polymorphisms in Moroccan visceral leishmaniasis patients

Acta Tropica ◽  
2016 ◽  
Vol 158 ◽  
pp. 77-82 ◽  
Author(s):  
Rajaâ Ejghal ◽  
Moustapha Hida ◽  
Mounya Lahkim Bennani ◽  
Mariame Meziane ◽  
Rabia Aurag ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Gene Polymorphisms ◽  
Tlr4 Gene

scholarly journals TLR4 and TLR9 polymorphism: Probable role in susceptibility among the population of Bihar for Indian visceral leishmaniasis

2021 ◽  
pp. 175342592096565
Author(s):  
Abhishek Mandal ◽  
Manish Kumar ◽  
Ashish Kumar ◽  
Abhik Sen ◽  
Pradeep Das ◽  
...  
Keyword(s):  
Visceral Leishmaniasis ◽  
Healthy Volunteers ◽  
Gene Polymorphisms ◽  
Indian Population ◽  
Pcr Amplification ◽  
Healthy Controls ◽  
Host Pathogen Interaction ◽  
Tlr4 Gene ◽  
Probable Role ◽  
Bihar State

Genetic variations in the host TLRs genes play an important role in susceptibility and/or resistance to visceral leishmaniasis by altering the host-pathogen interaction. In this study, we investigated the association between polymorphisms of TLR4 (Asp299Gly, Thr399Ile) and TLR-9 (T-1237C), with susceptibility to visceral leishmaniasis. A bi-directional PCR amplification of specific alleles technique was used to characterize the distribution of TLR4 (Asp299Gly and Thr399Ile) and TLR9 (T-1237C) polymorphisms. A total of 60 samples were randomly selected from confirmed visceral leishmaniasis patients and 24 endemic healthy volunteers. The samples were genotyped and allele frequencies were determined. We observed that TLR4 Asp299Gly and Thr399Ile genotypes were more frequent in visceral leishmaniasis patients (10% and 15% respectively) compared to controls (4.2% and 8.3% respectively). However, the differences were not significant in TLR4 Asp299Gly and Thr399Ile alleles and genotypes. In the case of TLR9, we observed the frequency of T1237C genotype was higher in visceral leishmaniasis patients (43.3%) than in healthy controls (33.3%). Statistically significant differences were observed in TLR9 T1237C alleles and genotypes. We concluded that TLR9 T1237C, but not TLR4, gene polymorphisms can be regarded as contributors to visceral leishmaniasis susceptibility among the Indian population of Bihar state.

Association of TLR4 gene polymorphisms with sepsis after a burn injury: findings of the functional role of rs2737190 SNP

2021 ◽  
Author(s):  
Claudia A. Colín-Castro ◽  
Rafael Franco-Cendejas ◽  
Hector I. Rocha-González ◽  
Esteban Cruz-Arenas ◽  
Norberto Leyva-García ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Functional Role ◽  
Burn Injury ◽  
Tlr4 Gene

scholarly journals Association between TLR2 and TLR4 Gene Polymorphisms and the Susceptibility to Inflammatory Bowel Disease: A Meta-Analysis

PLoS ONE ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. e0126803 ◽  
Author(s):  
Yang Cheng ◽  
Yun Zhu ◽  
Xiuping Huang ◽  
Wei Zhang ◽  
Zelong Han ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Tlr4 Gene ◽  
Inflammatory Bowel

P253 ASSOCIATION OF TLR4 GENE POLYMORPHISMS WITH GASTRODUODENAL DISEASES AMONG PATIENTS WITH HELICOBACTERIOSIS

2020 ◽  
Vol 125 (5) ◽  
pp. S38-S39
Author(s):  
O. Yanovich ◽  
L. Titov ◽  
M. Doroshko ◽  
L. DuBuske
Keyword(s):  
Gene Polymorphisms ◽  
Tlr4 Gene

The TLR4 gene polymorphisms and susceptibility to cancer: A systematic review and meta-analysis

2013 ◽  
Vol 49 (4) ◽  
pp. 946-954 ◽  
Author(s):  
Kui Zhang ◽  
Bin Zhou ◽  
Yanyun Wang ◽  
Li Rao ◽  
Lin Zhang
Keyword(s):  
Systematic Review ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Tlr4 Gene

Association between TLR2/TLR4 gene polymorphisms and COPD phenotype in a Greek cohort

Herz ◽  
2016 ◽  
Vol 42 (8) ◽  
pp. 752-757 ◽  
Author(s):  
A. Apostolou ◽  
T. Kerenidi ◽  
A. Michopoulos ◽  
K. I. Gourgoulianis ◽  
M. Noutsias ◽  
...  
Keyword(s):  
Gene Polymorphisms ◽  
Tlr4 Gene
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