The role of alkyl chain length of monothiol-terminated alkyl carboxylic acid in the synthesis, characterization, and application of gelatin-g-poly(N-isopropylacrylamide) carriers for antiglaucoma drug delivery

2017 ◽  
Vol 49 ◽  
pp. 344-357 ◽  
Author(s):  
Li-Jyuan Luo ◽  
Jui-Yang Lai
Keyword(s):  
Drug Delivery ◽  
Carboxylic Acid ◽  
Chain Length ◽  
Alkyl Chain ◽  
Alkyl Chain Length ◽  
Antiglaucoma Drug

scholarly journals Responsive Polyesters with Alkene and Carboxylic Acid Side-Groups for Tissue Engineering Applications

Polymers ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1636
Author(s):  
Stella Afroditi Mountaki ◽  
Maria Kaliva ◽  
Konstantinos Loukelis ◽  
Maria Chatzinikolaidou ◽  
Maria Vamvakaki
Keyword(s):  
Carboxylic Acid ◽  
Chain Length ◽  
Main Chain ◽  
Alkyl Chain ◽  
Click Reaction ◽  
Irradiation Time ◽  
Alkyl Chain Length ◽  
Polymer Chains ◽  
Condensation Polymerization ◽  
L929 Fibroblast

Main chain polyesters have been extensively used in the biomedical field. Despite their many advantages, including biocompatibility, biodegradability, and others, these materials are rather inert and lack specific functionalities which will endow them with additional biological and responsive properties. In this work, novel pH-responsive main chain polyesters have been prepared by a conventional condensation polymerization of a vinyl functionalized diol with a diacid chloride, followed by a photo-induced thiol-ene click reaction to attach functional carboxylic acid side-groups along the polymer chains. Two different mercaptocarboxylic acids were employed, allowing to vary the alkyl chain length of the polymer pendant groups. Moreover, the degree of modification, and as a result, the carboxylic acid content of the polymers, was easily tuned by varying the irradiation time during the click reaction. Both these parameters, were shown to strongly influence the responsive behavior of the polyesters, which presented adjustable pKα values and water solubilities. Finally, the difunctional polyesters bearing the alkene and carboxylic acid functionalities enabled the preparation of cross-linked polyester films by chemically linking the pendant vinyl bonds on the polymer side groups. The biocompatibility of the cross-linked polymers films was assessed in L929 fibroblast cultures and showed that the cell viability, proliferation, and attachment were greatly promoted on the polyester surface, bearing the shorter alkyl chain length side groups and the higher fraction of carboxylic acid functionalities.

scholarly journals Membrane-destabilizing activity of pH-responsive cationic lysine-based surfactants: role of charge position and alkyl chain length

Amino Acids ◽  
2011 ◽  
Vol 43 (3) ◽  
pp. 1203-1215 ◽  
Author(s):  
Daniele Rubert Nogueira ◽  
Montserrat Mitjans ◽  
M. Carmen Morán ◽  
Lourdes Pérez ◽  
M. Pilar Vinardell
Keyword(s):  
Chain Length ◽  
Alkyl Chain ◽  
Alkyl Chain Length ◽  
Ph Responsive

The transfection efficiency of calix[4]arene-based lipids: the role of the alkyl chain length

2015 ◽  
Vol 3 (2) ◽  
pp. 317-322 ◽  
Author(s):  
Shinichi Mochizuki ◽  
Koichi Nishina ◽  
Shota Fujii ◽  
Kazuo Sakurai
Keyword(s):  
Chain Length ◽  
Plasmid Dna ◽  
Alkyl Chain ◽  
Transfection Efficiency ◽  
Alkyl Chain Length ◽  
Chain Lengths

Calix[4]arene-based lipids with the C6 alkyl chain length exhibited the highest transfection efficiency among all lipoplexes comprising the lipids with different alkyl chain lengths and plasmid DNA.

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