Centrifugally concentric ring-patterned drug-loaded polymeric coating as an intraocular lens surface modification for efficient prevention of posterior capsular opacification

2021 ◽  
Author(s):  
Duoduo Lu ◽  
Yuemei Han ◽  
Dong Liu ◽  
Siqi Chen ◽  
Jiqiao Qie ◽  
...  
Keyword(s):  
Surface Modification ◽  
Intraocular Lens ◽  
Polymeric Coating ◽  
Posterior Capsular Opacification ◽  
Concentric Ring ◽  
Lens Surface

scholarly journals Facile multifunctional IOL surface modification via poly(PEGMA-co-GMA) grafting for posterior capsular opacification inhibition

RSC Advances ◽  
2021 ◽  
Vol 11 (17) ◽  
pp. 9840-9848
Author(s):  
Jiayi Xia ◽  
Duoduo Lu ◽  
Yuemei Han ◽  
Jiahao Wang ◽  
Yueze Hong ◽  
...  
Keyword(s):  
Surface Modification ◽  
Intraocular Lens ◽  
Surface Coating ◽  
Posterior Capsular Opacification ◽  
Drug Eluting ◽  
Lens Surface

Drug eluting and hydrophilic intraocular lens surface coating was facilely fabricated via poly(PEGMA-co-GMA) grafting. Such a multifunctional coating reduced posterior capsular opacification incidence after implantation effectively.

scholarly journals The Efficacy of an Acrylic Intraocular Lens Surface Modified with Polyethylene Glycol in Posterior Capsular Opacification

2007 ◽  
Vol 22 (3) ◽  
pp. 502 ◽  
Author(s):  
Hyeon Il Lee ◽  
Mee Kum Kim ◽  
Jung Hwa Ko ◽  
Hyun Ju Lee ◽  
Won Ryang Wee ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Intraocular Lens ◽  
Posterior Capsular Opacification ◽  
Surface Modified ◽  
Lens Surface

Drug Eluting Intraocular Lens Surface Modification for PCO Prevention

2018 ◽  
Vol 24 ◽  
pp. 40-44 ◽  
Author(s):  
Yuemei Han ◽  
Xu Xu ◽  
Yuqin Wang ◽  
Sihao Liu ◽  
Xia Zhao ◽  
...  
Keyword(s):  
Surface Modification ◽  
Intraocular Lens ◽  
Drug Eluting ◽  
Lens Surface

VUV-photon Induced Formation of Hydrophilic and Hydrophobic Micro Domains Structure on Intraocular Lens Surface for Blocking after Cataract

2007 ◽  
Vol 1054 ◽  
Author(s):  
Yuji Sato ◽  
Kenji Kawai ◽  
Mikio Sasoh ◽  
Hiroaki Ozaki ◽  
Takeo Ohki ◽  
...  
Keyword(s):  
Surface Modification ◽  
Infrared Spectroscopy ◽  
Intraocular Lens ◽  
Laser Light ◽  
Ultra Violet ◽  
Hydrophobic Surface ◽  
Sample Surface ◽  
Oh Groups ◽  
Ft Ir ◽  
Lens Surface

ABSTRACTA micro domain structure, which hydrophilic and hydrophobic groups were arrayed alternately, was formed on the surface of an intraocular lens [IOL] by using ultra violet rays [VUV]. With this technique, the IOL that is free from fibrin has been developed. In order to substitute the hydrophilic groups in matrix-form on the surface, an ArF laser light was then irradiated on the hydrophobic surface in the presence of water for the −OH groups, through the 50-micrometer dot-patterned reticle. With this selective photochemical surface modification, the hydrophilic and hydrophobic groups were arrayed alternately on the sample surface. The modified IOL was soaked in 0.1-wt % fibrin solutions, and the fibrin-sticking rate was measured by using an infrared spectroscopy [FT-IR]. It results that the absorption coefficient of amide band reached to 0.0006, decreasing to one-six of non-treatment sample's.

scholarly journals Anti-Adhesive And Antiproliferative Synergistic Surface Modification Of Intraocular Lens For Reduced Posterior Capsular Opacification

2019 ◽  
Vol Volume 14 ◽  
pp. 9047-9061 ◽  
Author(s):  
Yuemei Han ◽  
Junmei Tang ◽  
Jiayi Xia ◽  
Rui Wang ◽  
Chen Qin ◽  
...  
Keyword(s):  
Surface Modification ◽  
Intraocular Lens ◽  
Posterior Capsular Opacification

scholarly journals A COMPARISION OF POSTERIOR CAPSULAR OPACITY FORMATION UPTO 1 YEAR IN PATIENTS WITH SMALL INCISION CATARACT SURGERY WITH FOLDABLE INTRAOCULAR LENS AND PHACOEMULSIFICATION WITH THE SAME INTRAOCULAR LENS

2020 ◽  
pp. 173-176
Author(s):  
Kinjal Rathod ◽  
Kinjal Trivedi ◽  
Snehal Nayi ◽  
Somesh Aggarwal
Keyword(s):  
Visual Acuity ◽  
Cataract Surgery ◽  
Intraocular Lens ◽  
Nd:Yag Laser ◽  
Visual Outcome ◽  
Posterior Capsular Opacification ◽  
P Value ◽  
Small Incision Cataract Surgery ◽  
Common Procedure ◽  
Age Related

Introduction: Cataract is most common cause of curable blindness worldwide and cataract surgery is most common procedure performed in ophthalmology. Posterior capsular opacification (PCO) is most common complication after cataract surgery which is usually treated with Neodymium-doped: Yttrium Garnet (Nd:YAG) laser posterior capsulotomy or occasionally with a surgical capsulotomy. The incidence and severity of PCO correlates to the type of surgical technique, IOL optic edge designs and IOL materials. Material and Methods: 70 eyes of 64 patients operated for age related cataract were studied in this prospective interventional study. Phacoemulsification was done in 35 eyes and SICS in 35 eyes with hydrophobic single piece biconvex foldable intraocular lens. Patients were followed up at 1, 3, 6, 9 and 12 months for the development of PCO. Clinically significant PCO (loss of 2 or more lines of Snellen’s visual acuity chart) was treated with Nd:YAG laser capsulotomy. Results: The overall incidence of PCO was 22.85%. Amongst the patients who developed PCO, SICS and phacoemulsification was performed in 62.5% and 37.5% patients respectively. Result was statistically significant with p value <0.05 using z test. On first postoperative day, patients operated with phacoemulsification had better visual acuity than SICS. Conclusion: Phacoemulsification can provide early and better visual outcome than SICS and has lower incidence of PCO formation which may be due to difference in irrigation and aspiration and less disruption of blood aqueous barrier than SICS. PCO can be reduced by atraumatic surgery and thorough cortical clean up and capsular polishing.

scholarly journals Posterior capsular calcification without opacification of intraocular lens

2016 ◽  
Vol 8 (1) ◽  
pp. 91-94
Author(s):  
Rajesh S Joshi
Keyword(s):  
Visual Acuity ◽  
Intraocular Lens ◽  
Posterior Capsule ◽  
Posterior Capsular Opacification ◽  
Slit Lamp ◽  
Peripheral Part ◽  
Postoperative Visual Acuity ◽  
The Third ◽  
Early Occurrence

Background: Posterior capsular clarity is important for long-term visual gain. Postoperative visual acuity could be reduced due to posterior capsular or intraocular lens opacification, which occur months or years after cataract surgery. We report early occurrence of posterior capsular calcification without opacification of intraocular lens. Case: We report the case of a 78-year-old male who had undergone phacoemulsification with implantation of hydrophilic intraocular lens (IOL) in the left eye for cataract. The patient was non-diabetic, and the surgical procedure was uneventful. On the third postoperative day, fine granular deposits were found on the mid-peripheral part of the posterior capsule. No deposits were found on IOL. The patient presented with diminished vision four months after surgery. Slit-lamp examination revealed distinct areas of calcification with an early opacification of the posterior capsule and no IOL calcification. Neodymium doped: YAG capsulotomy was done to clear posterior capsular opacification, and the patient regained visual acuity of 20/20. To the best of our knowledge, this report is the first to investigate posterior capsular calcification without opacification of IOL in a patient without any known etiological factors. Conclusion: This case is reported to stimulate future study on the use of BSS plus and the development of posterior capsular or IOL calcification. Nepal J Ophthalmol 2016; 8(15): 91-94

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