Drug Eluting Intraocular Lens Surface Modification for PCO Prevention

Drug eluting and hydrophilic intraocular lens surface coating was facilely fabricated via poly(PEGMA-co-GMA) grafting. Such a multifunctional coating reduced posterior capsular opacification incidence after implantation effectively.

Download Full-text

Centrifugally concentric ring-patterned drug-loaded polymeric coating as an intraocular lens surface modification for efficient prevention of posterior capsular opacification

Acta Biomaterialia ◽

10.1016/j.actbio.2021.11.018 ◽

2021 ◽

Author(s):

Duoduo Lu ◽

Yuemei Han ◽

Dong Liu ◽

Siqi Chen ◽

Jiqiao Qie ◽

...

Keyword(s):

Surface Modification ◽

Intraocular Lens ◽

Polymeric Coating ◽

Posterior Capsular Opacification ◽

Concentric Ring ◽

Lens Surface

Download Full-text

VUV-photon Induced Formation of Hydrophilic and Hydrophobic Micro Domains Structure on Intraocular Lens Surface for Blocking after Cataract

MRS Proceedings ◽

10.1557/proc-1054-ff05-18 ◽

2007 ◽

Vol 1054 ◽

Author(s):

Yuji Sato ◽

Kenji Kawai ◽

Mikio Sasoh ◽

Hiroaki Ozaki ◽

Takeo Ohki ◽

...

Keyword(s):

Surface Modification ◽

Infrared Spectroscopy ◽

Intraocular Lens ◽

Laser Light ◽

Ultra Violet ◽

Hydrophobic Surface ◽

Sample Surface ◽

Oh Groups ◽

Ft Ir ◽

Lens Surface

ABSTRACTA micro domain structure, which hydrophilic and hydrophobic groups were arrayed alternately, was formed on the surface of an intraocular lens [IOL] by using ultra violet rays [VUV]. With this technique, the IOL that is free from fibrin has been developed. In order to substitute the hydrophilic groups in matrix-form on the surface, an ArF laser light was then irradiated on the hydrophobic surface in the presence of water for the −OH groups, through the 50-micrometer dot-patterned reticle. With this selective photochemical surface modification, the hydrophilic and hydrophobic groups were arrayed alternately on the sample surface. The modified IOL was soaked in 0.1-wt % fibrin solutions, and the fibrin-sticking rate was measured by using an infrared spectroscopy [FT-IR]. It results that the absorption coefficient of amide band reached to 0.0006, decreasing to one-six of non-treatment sample's.

Download Full-text

The Efficacy of an Acrylic Intraocular Lens Surface Modified with Polyethylene Glycol in Posterior Capsular Opacification

Journal of Korean Medical Science ◽

10.3346/jkms.2007.22.3.502 ◽

2007 ◽

Vol 22 (3) ◽

pp. 502 ◽

Cited By ~ 6

Author(s):

Hyeon Il Lee ◽

Mee Kum Kim ◽

Jung Hwa Ko ◽

Hyun Ju Lee ◽

Won Ryang Wee ◽

...

Keyword(s):

Polyethylene Glycol ◽

Intraocular Lens ◽

Posterior Capsular Opacification ◽

Surface Modified ◽

Lens Surface

Download Full-text

Surface Modification of Intraocular Lens with Hydrophilic Poly(Sulfobetaine Methacrylate) Brush for Posterior Capsular Opacification Prevention

Journal of Ocular Pharmacology and Therapeutics ◽

10.1089/jop.2020.0134 ◽

2021 ◽

Author(s):

Rui Wang ◽

Jiayi Xia ◽

Junmei Tang ◽

Dong Liu ◽

Siqing Zhu ◽

...

Keyword(s):

Surface Modification ◽

Intraocular Lens ◽

Posterior Capsular Opacification

Download Full-text

In vitro biofilm distribution on the intraocular lens surface of different biomaterials

Journal of Cataract & Refractive Surgery ◽

10.1016/j.jcrs.2015.05.029 ◽

2015 ◽

Vol 41 (9) ◽

pp. 1980-1988 ◽

Cited By ~ 2

Author(s):

Paloma Mazoteras ◽

Ricardo Pedro Casaroli-Marano

Keyword(s):

Intraocular Lens ◽

Lens Surface

Download Full-text

Physicochemical Analysis of Sediments Formed on the Surface of Hydrophilic Intraocular Lens after Descemet’s Stripping Endothelial Keratoplasty

Materials ◽

10.3390/ma13184145 ◽

2020 ◽

Vol 13 (18) ◽

pp. 4145

Author(s):

Dorota Tarnawska ◽

Katarzyna Balin ◽

Maria Jastrzębska ◽

Agnieszka Talik ◽

Roman Wrzalik

Keyword(s):

Intraocular Lens ◽

Photoelectron Spectroscopy ◽

Inorganic Compounds ◽

Chemical Imaging ◽

Physicochemical Analysis ◽

Endothelial Keratoplasty ◽

Surface Mass ◽

Microscopic Studies ◽

Descemet’S Stripping Endothelial Keratoplasty ◽

Lens Surface

An intraocular lens (IOL) is a synthetic, artificial lens placed inside the eye that replaces a natural lens that is surgically removed, usually as part of cataract surgery. The opacification of the artificial lens can be related to the formation of the sediments on its surface and could seriously impair vision. The physicochemical analysis was performed on an explanted hydrophilic IOL and compared to the unused one, considered as a reference IOL. The studies were carried out using surface sensitive techniques, which can contribute to a better understanding of the sedimentation process on hydrophilic IOLs’ surfaces. The microscopic studies allowed us to determine the morphology of sediments observed on explanted IOL. The photoelectron spectroscopy measurements revealed the presence of organic and inorganic compounds at the lens surface. Mass spectroscopy measurements confirmed the chemical composition of deposits and allowed for chemical imaging of the IOL surface. Applied techniques allowed to obtain a new set of information approximating the origin of the sediments’ formation on the surface of the hydrophilic IOLs after Descemet’s stripping endothelial keratoplasty.

Download Full-text

Implications for the biofunctionalization of drug-eluting devices at the example of a site-selective antibody modification for drug eluting stents

BioNanoMaterials ◽

10.1515/bnm-2015-0009 ◽

2015 ◽

Vol 16 (4) ◽

Cited By ~ 1

Author(s):

Svea Petersen ◽

Christiane Häcker ◽

Gökmen Turan ◽

Stefanie Knödler ◽

Andreas Brodehl ◽

...

Keyword(s):

Surface Modification ◽

Storage Conditions ◽

General Information ◽

Drug Eluting Stents ◽

Surface Loading ◽

Surface Functionality ◽

Drug Eluting ◽

A Site ◽

Selective Immobilization ◽

Site Selective

AbstractFunctionality of implant surfaces is considerably determined by the conformations of immobilized biomolecules adjustable by the applied surface modification approach. Moreover, surface modification of drug eluting systems often needs to be thoroughly optimized with regard to possible drug losses associated with a loss of functionality. Here, we thoroughly investigate biomolecule surface loading, functionality, morphology and stability in dependence of modification conditions at the example of a site-selective immobilization of anti-CD34 antibodies (CD34-Ab) to drug-eluting stents with the aim of providing general information on the biofunctionalization of drug eluting systems. In this context, we demonstrate that the reaction time of biomolecule immobilization defines achievable surface loads but also drug loss. We could moreover show that the used site-selective immobilization procedure elevated the surface functionality considerably in comparison to surfaces modified by random physisorption. Furthermore investigated bionfunctional stability gives important indications for storage conditions of biofunctionalized implants.

Download Full-text