Microsphere Sensors for Charactering Stress Fields Within Three-Dimensional Extracellular Matrix

2022 ◽  
Author(s):  
Xin Ding ◽  
Moxiao Li ◽  
Bo Cheng ◽  
Zhao Wei ◽  
Yuqing Dong ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Three Dimensional ◽  
Stress Fields

Microsphere Sensors for Charactering Stress Fields within Three-Dimensional Extracellular Matrix

2021 ◽  
Author(s):  
Xin Ding ◽  
Moxiao Li ◽  
Bo Cheng ◽  
Zhao Wei ◽  
Yuqing Dong ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Three Dimensional ◽  
Stress Fields

Induction of in Vivo Ectopic Hematopoiesis by a Three-Dimensional Structured Extracellular Matrix Derived from Decellularized Cancellous Bone

2019 ◽  
Vol 5 (11) ◽  
pp. 5669-5680 ◽  
Author(s):  
Naoko Nakamura ◽  
Tsuyoshi Kimura ◽  
Kwangwoo Nam ◽  
Toshiya Fujisato ◽  
Hiroo Iwata ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cancellous Bone ◽  
Three Dimensional

Three-dimensional elastic stress fields near notches in finite thickness plates

2000 ◽  
Vol 37 (51) ◽  
pp. 7617-7632 ◽  
Author(s):  
Zhenhuan Li ◽  
Wanlin Guo ◽  
Zhenbang Kuang
Keyword(s):  
Elastic Stress ◽  
Finite Thickness ◽  
Three Dimensional ◽  
Stress Fields

scholarly journals Artificial Tumor Microenvironments in Neuroblastoma

Cancers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1629
Author(s):  
Colin H. Quinn ◽  
Andee M. Beierle ◽  
Elizabeth A. Beierle
Keyword(s):  
Extracellular Matrix ◽  
Three Dimensional ◽  
Therapeutic Interventions ◽  
3D Bioprinting ◽  
Culture Studies ◽  
In Vivo Models ◽  
Novel Treatments ◽  
Tumor Microenvironments ◽  
Novel Approach

In the quest to advance neuroblastoma therapeutics, there is a need to have a deeper understanding of the tumor microenvironment (TME). From extracellular matrix proteins to tumor associated macrophages, the TME is a robust and diverse network functioning in symbiosis with the solid tumor. Herein, we review the major components of the TME including the extracellular matrix, cytokines, immune cells, and vasculature that support a more aggressive neuroblastoma phenotype and encumber current therapeutic interventions. Contemporary treatments for neuroblastoma are the result of traditional two-dimensional culture studies and in vivo models that have been translated to clinical trials. These pre-clinical studies are costly, time consuming, and neglect the study of cofounding factors such as the contributions of the TME. Three-dimensional (3D) bioprinting has become a novel approach to studying adult cancers and is just now incorporating portions of the TME and advancing to study pediatric solid. We review the methods of 3D bioprinting, how researchers have included TME pieces into the prints, and highlight present studies using neuroblastoma. Ultimately, incorporating the elements of the TME that affect neuroblastoma responses to therapy will improve the development of innovative and novel treatments. The use of 3D bioprinting to achieve this aim will prove useful in developing optimal therapies for children with neuroblastoma.

scholarly journals Special Issue: Application of Extracellular Matrix in Regenerative Medicine

2021 ◽  
Vol 11 (7) ◽  
pp. 3262
Author(s):  
Neill J. Turner
Keyword(s):  
Extracellular Matrix ◽  
Regenerative Medicine ◽  
Wound Repair ◽  
Three Dimensional ◽  
Dynamic Structure ◽  
Scaffold Material ◽  
Special Issue ◽  
Organ Regeneration ◽  
Scaffold Materials ◽  
The Many

The present Special Issue comprises a collection of articles addressing the many ways in which extracellular matrix (ECM), or its components parts, can be used in regenerative medicine applications. ECM is a dynamic structure, composed of a three-dimensional architecture of fibrous proteins, proteoglycans, and glycosaminoglycans, synthesized by the resident cells. Consequently, ECM can be considered as nature’s ideal biologic scaffold material. The articles in this Special Issue cover a range of topics from the use of ECM components to manufacture scaffold materials, understanding how changes in ECM composition can lead to the development of disease, and how decellularization techniques can be used to develop tissue-derived ECM scaffolds for whole organ regeneration and wound repair. This editorial briefly summarizes the most interesting aspects of these articles.

scholarly journals The effect of the outlet angle β2 on the thermomechanical behavior of a centrifugal compressor blade

2020 ◽  
Vol 29 (1) ◽  
pp. 1-8
Author(s):  
Ahmed Allali ◽  
Sadia Belbachir ◽  
Ahmed Alami ◽  
Belhadj Boucham ◽  
Abdelkader Lousdad
Keyword(s):  
Mechanical Behavior ◽  
Centrifugal Compressor ◽  
Three Dimensional ◽  
Complex Form ◽  
Compressor Blade ◽  
Stress Fields ◽  
The Finite Element Method ◽  
Mechanical Fatigue ◽  
Outlet Angle ◽  
The Impact

AbstractThe objective of this work lies in the three-dimensional study of the thermo mechanical behavior of a blade of a centrifugal compressor. Numerical modeling is performed on the computational code "ABAQUS" based on the finite element method. The aim is to study the impact of the change of types of blades, which are defined as a function of wheel output angle β2, on the stress fields and displacements coupled with the variation of the temperature.This coupling defines in a realistic way the thermo mechanical behavior of the blade where one can note the important concentrations of stresses and displacements in the different zones of its complex form as well as the effects at the edges. It will then be possible to prevent damage and cracks in the blades of the centrifugal compressor leading to its failure which can be caused by the thermal or mechanical fatigue of the material with which the wheel is manufactured.

scholarly journals Universal characterization of three-dimensional creeping crack-front stress fields

2018 ◽  
Vol 152-153 ◽  
pp. 104-117 ◽  
Author(s):  
Wanlin Guo ◽  
Zhiyuan Chen ◽  
Chongmin She
Keyword(s):  
Crack Front ◽  
Three Dimensional ◽  
Stress Fields

Generation of Cell-Derived Three Dimensional Extracellular Matrix Substrates from Two Dimensional Endothelial Cell Cultures

2011 ◽  
Vol 17 (5) ◽  
pp. 589-595 ◽  
Author(s):  
Christopher M. Zwolinski ◽  
Karen S. Ellison ◽  
Natacha DePaola ◽  
Deanna M. Thompson
Keyword(s):  
Extracellular Matrix ◽  
Endothelial Cell ◽  
Cell Cultures ◽  
Three Dimensional ◽  
Two Dimensional ◽  
Endothelial Cell Cultures

Transplantation of three-dimensional artificial human vascular tissues fabricated using an extracellular matrix nanofilm-based cell-accumulation technique

2015 ◽  
Vol 11 (4) ◽  
pp. 1303-1307 ◽  
Author(s):  
Yoshiya Asano ◽  
Hiroshi Shimoda ◽  
Daisuke Okano ◽  
Michiya Matsusaki ◽  
Mitsuru Akashi
Keyword(s):  
Extracellular Matrix ◽  
Three Dimensional ◽  
Vascular Tissues ◽  
Cell Accumulation
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