Left ventricular diastolic dysfunction in type II diabetes mellitus with preserved systolic function: Prevalence and associated factors

Background: Epidemiological data indicates a greater risk of cardiovascular morbidity and mortality, particularly congestive heart failure in diabetic patients, compared with nondiabetic patients. Heart failure in many patients is due to left Ventricular Diastolic Dysfunction (LVDD), but its prevalence among diabetic adults is still not known, especially in the primary health care settings. Present study aims to evaluate the prevalence of LVDD by Echocardiography in Type II Diabetes Mellitus (DM).Methods: Authors did a prospective study, from May 2012 to August 2014, in Department of Medicine, Dr. D. Y. Patil Hospital, Kolhapur which included 100 randomly selected patients of Type II DM. The diagnosis of Type II DM was done according to the criteria laid down by American Diabetes Association 2012. A detailed clinical history was taken using a structured questionnaire prepared by us and all patients were evaluated for left ventricular function by Echocardiography. Equipment used for echocardiography-Mind ray DC USG, Doppler machine Probe used-7.5MHz.Results: On Echocardiography, Diastolic Dysfunction was found to be prevalent among individuals with Type 2 DM. Duration of DM and increasing age were found to be significantly associated with presence of Diastolic Dysfunction among individuals with Type 2 DM. Maximum number of patients were observed in the age group 51-60 years in our institute. 45% of the patients were asymptomatic, rest of the patients had predominantly cardiac symptoms.Conclusions: It is essential to screen diabetic patients with Echocardiography at an early stage to prevent future cardiovascular complications.

Download Full-text

Glycosylated hemoglobin and left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus

International Journal of Research in Medical Sciences ◽

10.18203/2320-6012.ijrms20175450 ◽

2017 ◽

Vol 5 (12) ◽

pp. 5330 ◽

Cited By ~ 1

Author(s):

Vishal S. Yesankar ◽

Nalini R. Humaney

Keyword(s):

Diabetes Mellitus ◽

Diastolic Dysfunction ◽

Glycosylated Hemoglobin ◽

Left Ventricular Diastolic Dysfunction ◽

Left Ventricular ◽

Type I ◽

Type Ii ◽

Chi Square ◽

Ventricular Diastolic Dysfunction

Background: Diabetes mellitus is one of the most common diseases. Left ventricular diastolic dysfunction may represent the early stage of diabetic cardiomyopathy thus reinforcing the importance of the early examination of diastolic function in individuals with diabetes.Methods: This is a hospital based cross-sectional study done at a tertiary care hospital catering mainly to rural population. Patients having type 2 diabetes mellitus were scrutinized for doppler echocardiography and HbA1c levels. As per the previous studies and considering the prevalence of asymptomatic diastolic dysfunction in diabetics, the sample size was calculated. Statistical analysis was done by using descriptive and inferential statistics using chi square test.Results: In the present study 45 patients had HbA1C between 6.5- 8.0, out of which 9 had type I diastolic dysfunction, 1 had type II diastolic dysfunction and 35 had no diastolic dysfunction. 16 patients had HbA1C between 8.1- 9.5, out of which 7 had type I diastolic dysfunction, 8 had type II diastolic dysfunction and 1 had no diastolic dysfunction. 14 patients had HbA1C more than 9.5, out of which 4 had type I diastolic dysfunction, 5 had type II diastolic dysfunction, 4 had type III diastolic dysfunction and 1 patient did not had any diastolic dysfunction. The Chi-Square value is 55.51 and p value is 0.000 (Significant).Conclusions: Diastolic dysfunction correlates with the levels of glycosylated hemoglobin, duration of diabetes mellitus, presence of microvascular complications like diabetic retinopathy, neuropathy and nephropathy.

Download Full-text