The challenges facing block copolymer micelles for cancer therapy: In vivo barriers and clinical translation

2015 ◽  
Vol 91 ◽  
pp. 7-22 ◽  
Author(s):  
Sina Eetezadi ◽  
Sandra N. Ekdawi ◽  
Christine Allen
Keyword(s):  
Block Copolymer ◽  
Cancer Therapy ◽  
Clinical Translation ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

scholarly journals Anthracycline antibiotics non-covalently incorporated into the block copolymer micelles: in vivo evaluation of anti-cancer activity

1996 ◽  
Vol 74 (10) ◽  
pp. 1545-1552 ◽  
Author(s):  
EV Batrakova ◽  
TY Dorodnych ◽  
EY Klinskii ◽  
EN Kliushnenkova ◽  
OB Shemchukova ◽  
...  
Keyword(s):  
Block Copolymer ◽  
In Vivo Evaluation ◽  
Anthracycline Antibiotics ◽  
Anti Cancer ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles ◽  
Cancer Activity

Comparison of Biomimetic Block Copolymer Micelles as Drug Carriers for Cancer Therapy

2017 ◽  
Vol 13 (11) ◽  
pp. 1500-1511 ◽  
Author(s):  
Gongyan Liu ◽  
Xiaobing Chen ◽  
Weihua Zhuang ◽  
Yu Nie ◽  
Kai Zhang ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Cancer Therapy ◽  
Drug Carriers ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

β-lactam Functionalized Poly(isoprene-b-ethylene oxide) Amphiphilic Block Copolymer Micelles as a New Nanocarrier System for Curcumin

2010 ◽  
Vol 6 (3) ◽  
pp. 277-284 ◽  
Author(s):  
Konstantinos Gardikis ◽  
Konstantinos Dimas ◽  
Aristidis Georgopoulos ◽  
Eleni Kaditi ◽  
Stergios Pispas ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Ethylene Oxide ◽  
Amphiphilic Block Copolymer ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

Donnan Equilibria in Polymeric Micellar Systems with Weak Polyelectrolyte Shells: The Lowering of the pH Value

1997 ◽  
Vol 62 (11) ◽  
pp. 1730-1736 ◽  
Author(s):  
Petr Munk ◽  
Zdeněk Tuzar ◽  
Karel Procházka
Keyword(s):  
Ionic Strength ◽  
Block Copolymer ◽  
Ph Value ◽  
Electrolyte Solutions ◽  
Hydrogen Ions ◽  
Micellar Systems ◽  
Weak Electrolytes ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles ◽  
Polyelectrolyte Solutions

When two electrolyte solutions are separated and only some of the ions can cross the boundary, the concentrations of these ions are different on both sides of the boundary. This is the well-known Donnan effect. When weak electrolytes are involved, the imbalance includes also hydrogen ions: there is a difference of pH across the boundary and the dissociation of nondiffusible weak electrolytes is suppressed. The effect is very pronounced when the concentration of the weak electrolyte is high and ionic strength is low. The significance of this phenomenon is discussed for polyelectrolyte solutions, and particularly for block copolymer micelles with weak polyelectrolyte shells. The effect is quite dramatic in the latter case.

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