Concurrent multiscale modeling of three dimensional crack and dislocation propagation

2015 ◽  
Vol 80 ◽  
pp. 82-92 ◽  
Author(s):  
Hossein Talebi ◽  
Mohammad Silani ◽  
Timon Rabczuk
Soft Matter ◽  
2019 ◽  
Vol 15 (10) ◽  
pp. 2204-2215 ◽  
Author(s):  
Emma Lejeune ◽  
Berkin Dortdivanlioglu ◽  
Ellen Kuhl ◽  
Christian Linder

Three-dimensional multiscale modeling shows that oriented cell division leads to a mechanical instability that can initiate cerebellar foliation.


Langmuir ◽  
2017 ◽  
Vol 33 (43) ◽  
pp. 12028-12037 ◽  
Author(s):  
Han Hu ◽  
Monojit Chakraborty ◽  
Taylor P. Allred ◽  
Justin A. Weibel ◽  
Suresh V. Garimella

Author(s):  
Alison L. Marsden ◽  
Mahdi Esmaily Moghadam ◽  
Weiguang Yang ◽  
Alessia Baretta ◽  
Chiara Corsini ◽  
...  

Multiscale modeling provides a means to relate global response to local changes in geometry and hemodynamics in the circulatory system. In this work, we couple a customized lumped parameter network (LPN) representing the whole circulation (heart, systemic and pulmonary circulations) to three-dimensional finite element models of two stages of the single ventricle surgical pathway. A fully-coupled closed-loop approach is employed using custom codes with Neumann boundary conditions at the inlets and outlets. The methodology is described, and applied to two stages of single ventricle repair to illustrate its utility: the BT-shunt (stage 1), and the Fontan surgery (stage 3).


2020 ◽  
Vol 16 (4) ◽  
pp. e1007709
Author(s):  
Xiaoning Zheng ◽  
Alireza Yazdani ◽  
He Li ◽  
Jay D. Humphrey ◽  
George E. Karniadakis

JOM ◽  
2015 ◽  
Vol 67 (8) ◽  
pp. 1776-1785 ◽  
Author(s):  
Damien Tourret ◽  
Amy J. Clarke ◽  
Seth D. Imhoff ◽  
Paul J. Gibbs ◽  
John W. Gibbs ◽  
...  

Science ◽  
2019 ◽  
Vol 366 (6472) ◽  
pp. 1492-1496 ◽  
Author(s):  
Yujiro Hayashi ◽  
Daigo Setoyama ◽  
Yoshiharu Hirose ◽  
Tomoyuki Yoshida ◽  
Hidehiko Kimura

The failure of polycrystalline materials used in infrastructure and transportation can be catastrophic. Multiscale modeling, which requires multiscale measurements of internal stress fields, is the key to predicting the deformation and failure of alloys. We determined the three-dimensional intragranular stress tensor fields in plastically deformed bulk steel using a high-energy x-ray microbeam. We observed intragranular local stresses that deviated greatly from the grain-averaged stresses and exceeded the macroscopic tensile strength. Even under deformation smaller than the uniform elongation, the intragranular stress fields were in highly triaxial stress states, which cannot be determined from the grain-averaged stresses. The ability to determine intragranular stress tensor fields can facilitate the understanding and prediction of the deformation and failure of materials through multiscale modeling.


2015 ◽  
Vol 137 (10) ◽  
Author(s):  
Fuyou Liang ◽  
Marie Oshima ◽  
Huaxiong Huang ◽  
Hao Liu ◽  
Shu Takagi

Free outflow boundary conditions have been widely adopted in hemodynamic model studies, they, however, intrinsically lack the ability to account for the regulatory mechanisms of systemic hemodynamics and hence carry a risk of producing incorrect results when applied to vascular segments with multiple outlets. In the present study, we developed a multiscale model capable of incorporating global cardiovascular properties into the simulation of blood flows in local vascular segments. The multiscale model was constructed by coupling a three-dimensional (3D) model of local arterial segments with a zero-one-dimensional (0-1-D) model of the cardiovascular system. Numerical validation based on an idealized model demonstrated the ability of the multiscale model to preserve reasonable pressure/flow wave transmission among different models. The multiscale model was further calibrated with clinical data to simulate cerebroarterial hemodynamics in a patient undergoing carotid artery operation. The results showed pronounced hemodynamic changes in the cerebral circulation following the operation. Additional numerical experiments revealed that a stand-alone 3D model with free outflow conditions failed to reproduce the results obtained by the multiscale model. These results demonstrated the potential advantage of multiscale modeling over single-scale modeling in patient-specific hemodynamic studies. Due to the fact that the present study was limited to a single patient, studies on more patients would be required to further confirm the findings.


2020 ◽  
Author(s):  
Qing Li ◽  
Luke Van Roekel

Abstract. A multiscale modeling approach for studying the ocean surface turbulent mixing is explored by coupling an ocean general circulation model (GCM) MPAS-Ocean with the PArallel Large eddy simulation Model (PALM). The coupling approach is similar to the superparameterization approach that has been used mostly to represent the effects of deep convection in atmospheric GCMs. However, since the emphasis here is on the small-scale turbulent mixing processes and their interactions with the larger-scale processes, a high-fidelity, three-dimensional large eddy simulation (LES) model is used, in contrary to a simplified process-resolving model with reduced physics or reduced dimension commonly used in the superparameterization literature. To reduce the computational cost, a customized version of PALM is ported on the general-purpose graphics processing unit (GPU) with OpenACC, achieving 10–16 times overall speedup as compared to running on a single CPU. Even with the GPU-acceleration technique, superparameterization of the ocean surface turbulent mixing using high-fidelity and three-dimensional LES over the global ocean in GCMs is still computationally intensive and infeasible for long simulations. However, running PALM regionally on selected MPAS-Ocean grid cells is shown to be a promising approach moving forward. The flexible coupling between MPAS-Ocean and PALM outlined here allows further exploration of the interactions between ocean surface turbulent mixing and larger-scale processes, and development of better ocean surface turbulent mixing parameterizations in GCMs.


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