scholarly journals Comparison of magnesium sulfate loading dose on ability to achieve a therapeutic level

2022 ◽  
Vol 226 (1) ◽  
pp. S744
Author(s):  
Melissa Westermann ◽  
Madushka De Zoysa ◽  
Tyler Yang ◽  
Judith H. Chung
Keyword(s):  
Magnesium Sulfate ◽  
Loading Dose ◽  
Therapeutic Level

scholarly journals Is Low Level of Serum Ionized Magnesium Responsible for Eclampsia?

1970 ◽  
Vol 27 (2) ◽  
pp. 76-81 ◽  
Author(s):  
Rabeya Akther ◽  
Maliha Rashid
Keyword(s):  
Magnesium Sulfate ◽  
Intramuscular Injection ◽  
Venous Blood ◽  
Magnesium Level ◽  
P Value ◽  
Loading Dose ◽  
Sodium Potassium ◽  
Ionized Magnesium ◽  
Low Level ◽  
The Relationship

Objective: To determine the level of serum ionized magnesium in eclampsia patient before and 24 hours after giving the loading dose of magnesium sulfate and if low, to determine the relationship between levels of ionized magnesium in serum and occurrence of eclamptic convulsions. Methods: Fifty eclampsia patients received a loading dose of 4 gm of magnesium sulfate, which was diluted with 12 ml of distilled water and then was given intravenously over a period of 10-15 minutes and it was followed by 3 gm of magnesium sulfate deep intramuscular injection in each buttock. Patient's venous blood samples were obtained before and 24hours after loading dose of magnesium sulfate and analyzed for ionized magnesium, sodium, potassium, and calcium level. Results: Level in eclampsia women is 0.47 (0.15-1.04) m mol/L and 0.74 (0.20-2.00) m mol/L before and 24 hours after treatment with loading dose of magnesium sulfate, respectively .This change is significant.( P value is < 0.001) . Change in ionized magnesium level associated with change in diastolic and systolic blood pressure, mean arterial pressure and albuminuria .This changes are also significant (p<.001). Conclusions: The evidence indicated that low level of ionized magnesium in serum may be the cause of eclamptic convulsion. Key words: Ionized magnesium, Eclampsia, magnesium sulfate. DOI: 10.3329/jbcps.v27i2.4250 J Bangladesh Coll Phys Surg 2009; 27: 76-81

Effect of the Loading Dose of Magnesium Sulfate (MgSO4) on the Parameters of Doppler Flow Velocity in the Uterine, Umbilical and Middle Cerebral Arteries in Severe Preeclampsia

2009 ◽  
Vol 29 (2) ◽  
pp. 123-134 ◽  
Author(s):  
Alex Sandro Rolland Souza ◽  
Melania Maria Ramos Amorim ◽  
Isabela Cristina, A. N. C. Coutinho ◽  
Marcelo Marques de Souza Lima ◽  
Carlos Noronha Neto ◽  
...  
Keyword(s):  
Magnesium Sulfate ◽  
Flow Velocity ◽  
Cerebral Arteries ◽  
Severe Preeclampsia ◽  
Loading Dose ◽  
Doppler Flow ◽  
Middle Cerebral Arteries

scholarly journals Lidocaine versus magnesium sulfate infusion during isoflurane anesthesia for brain tumor resection, effect on minimum alveolar concentration reduction guided by bispectral index: a prospective randomized controlled trial

2021 ◽  
Keyword(s):  
Brain Tumor ◽  
Magnesium Sulfate ◽  
Bispectral Index ◽  
Muscle Relaxant ◽  
Minimum Alveolar Concentration ◽  
Tumor Resection ◽  
Loading Dose ◽  
Depth Of Anesthesia ◽  
Lidocaine Group ◽  
Significant Difference

Objective: Goals of neuro-anesthesia include smooth induction, stable perioperative hemodynamics, early and quiet recovery with adequate analgesia. Intraoperative use of co-sedatives allows reduction of anesthetic agents consumption while maintaining a desirable depth of anesthesia. Many drugs like opioids and dexmedetomidine had been studied in different surgeries. Using such drugs enhances rapid recovery for early postoperative assessment and detection of complications. Methods: This study enrolled 50 adult patients undergoing supratentorial brain tumor surgery. Patients of the lidocaine group (group L) received 1.5 mg.kg−1 of lidocaine as a loading dose over 10 min before induction of anesthesia and followed by infusion at a rate of 1.5 mg.kg−1.h−1. Patients of the magnesium group (group M) received 30 mg.kg−1 of magnesium sulfate as a loading dose over 10 min before induction of anesthesia and followed by infusion at a rate of 10 mg.kg−1.h−1. Depth of anesthesia was guided by bispectral index in a range of 50 ± 2, with the primary outcome objective, minimum alveolar concentration reduction of inhaled isoflurane. Results: No significant difference was found regarding patient demographics, basal hemodynamic data, and anesthesia duration. The used isoflurane concentration at the matching time points (every 15 min intraoperatively) and the total dose of muscle relaxant (160 ± 15 mg, 175 ± 18 mg respectively, p 0.003) were statistically lower in group M than in group L. The time required for recovery was statistically shorter in group M than in group L (5.1 ± 0.99 min vs 9.8 ± 1.9 min, respectively, p 0.00). Conclusion: Compared to lidocaine infusion, magnesium sulfate (MgSO4) infusion during anesthesia for brain surgery resulted in lower anesthetic consumption, muscle relaxant requirement, a shorter recovery time, and a better postoperative pain profile. MgSO4 can be used effectively as a co-sedative adjuvant with superior clinical properties than lidocaine infusion.

Effect of the loading dose of magnesium sulfate on the Doppler velocimetry parameters in the uterine, umbilical and fetal middle cerebral arteries in severe preeclampsia

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Mohamed A ElKady ◽  
Noha H Rabie ◽  
Mohammed H Mostafa ◽  
Amany M Hafez
Keyword(s):  
Blood Flow ◽  
Magnesium Sulfate ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Cerebral Arteries ◽  
Resistance Index ◽  
Severe Preeclampsia ◽  
Loading Dose ◽  
Doppler Velocimetry ◽  
Middle Cerebral Arteries

Abstract Background Preeclampsia is pregnancy-specific syndrome of reduced organ perfusion secondary to vasospasm and endothelial activation. Aim of the Work to assess the effect of injecting magnesium sulfate on Doppler parameters of uterine artery, umbilical and fetal middle cerebral arteries (MCA) in women with severe preeclampsia. Patients and Methods This study included eighty pregnant with severe preeclampsia or eclampsia who were given magnesium sulphate therapy in Ain Shams University Maternity hospital. The Study group included 80 pregnant patients Doppler flow velocity parameters (resistance index [RI], pulsatility index [PI] and systolic/diastolic [S/D] ratio) were evaluated in the uterine, fetal umbilical and middle cerebral arteries before and 20 minutes after intravenous administration of 6 grams of magnesium sulfate (Loading dose). Results Magnesium sulfate had significant hemodynamic effects with significant reduction of systolic and diastolic blood pressure. Regarding the Doppler studies, it was found that after administration of magnesium sulfate there was significant reduction in the Doppler velocimetry parameters (Resistance index[RI], Pulsatility index[PI] and systolic/diastolic[S/D] ratio) in the uterine, umbilical and fetal middle cerebral arteries denoting decreased vascular resistance with increased blood flow in these vessels. Conclusion Intravenous administration of magnesium sulfate in pregnant women with severe preeclampsia and eclampsia resulted in a decrease in uterine artery, fetal umbilical and middle cerebral arteries Doppler indices with reduced resistance to blood flow in these vessels.

scholarly journals DIFFERENT REGIMENS OF MAGNESIUM SULFATE AND IT'S ROLE IN MANAGEMENT OF WOMEN WITH SEVERE PRE-ECLAMPSIA

2019 ◽  
Vol 3 (10) ◽  
Author(s):  
Amr M. H. Ibrahem ◽  
Ismael M.T. El-Garhy ◽  
Mohamed M. I. Gebril ◽  
Wael S. Taha
Keyword(s):  
Magnesium Sulfate ◽  
Gestational Age ◽  
Post Partum ◽  
Morbidity And Mortality ◽  
Controlled Study ◽  
Loading Dose ◽  
Standard Regimen ◽  
Diagnosis And Management ◽  
Randomized Controlled ◽  
High Incidence

Background: Preeclampsia constitutes a serious problem with high incidence that faces the workers in the field of obstetrics and needs good diagnosis and management and must not be neglected as maternal and fetal morbidity and mortality are so dangerous. Aim of the work: To different Regimens Of Magnesium Sulfate And It's Role In Management Of Women With Severe Pre-Eclampsia Patients and methods: A randomized controlled study that compared three regimens for administration of MgSO4 used for the cases of severe pre-eclampsia that was performed in the Obstetrics & Gynecology Department, Agouza police Hospital during the period from decemeber 2018 to the end of August 2019 Results: 240 patients were recruited for our study based on their presentation which was severe preeclampsia. Mean age of patients was; 26.65 years, SD 5.113 (range;16-42). Mean gestational age was; 35.75 weeks, SD 2.769 (range;28-40). Mean systolic BP was; 161.88mmHg, SD 17.121 (range;100-210). Mean diastolic BP was; 103.15, SD 12.127 (range;50-120). Conclusion: The use of loading dose only of MgSO4 in the ante-partum period with no post partum maintenance doses. If complications occurred, we recommend the abbreviated regimen as an alternative to the standard regimen.

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