scholarly journals Non-canonical functions of the Polycomb group protein EZH2 in breast cancer

2021 ◽  
Author(s):  
Talha Anwar ◽  
Maria E. Gonzalez ◽  
Celina G. Kleer
Keyword(s):  
Breast Cancer ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Group Protein

scholarly journals Integration of Estrogen and Wnt Signaling Circuits by the Polycomb Group Protein EZH2 in Breast Cancer Cells

2007 ◽  
Vol 27 (14) ◽  
pp. 5105-5119 ◽  
Author(s):  
Bin Shi ◽  
Jing Liang ◽  
Xiaohan Yang ◽  
Yan Wang ◽  
Youna Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Wnt Signaling ◽  
Cancer Cells ◽  
Transcriptional Activation ◽  
Breast Cancer Cells ◽  
Polycomb Group ◽  
Dual Function ◽  
Polycomb Group Protein ◽  
Dynamic Activity ◽  
Group Protein

ABSTRACT Essential for embryonic development, the polycomb group protein enhancer of zeste homolog 2 (EZH2) is overexpressed in breast and prostate cancers and is implicated in the growth and aggression of the tumors. The tumorigenic mechanism underlying EZH2 overexpression is largely unknown. It is believed that EZH2 exerts its biological activity as a transcription repressor. However, we report here that EZH2 functions in gene transcriptional activation in breast cancer cells. We show that EZH2 transactivates genes that are commonly targeted by estrogen and Wnt signaling pathways. We demonstrated that EZH2 physically interacts directly with estrogen receptor α and β-catenin, thus connecting the estrogen and Wnt signaling circuitries, functionally enhances gene transactivation by estrogen and Wnt pathways, and phenotypically promotes cell cycle progression. In addition, we identified the transactivation activity of EZH2 in its two N-terminal domains and demonstrated that these structures serve as platforms to connect transcription factors and the Mediator complex. Our experiments indicated that EZH2 is a dual function transcription regulator with a dynamic activity, and we provide a mechanism for EZH2 in tumorigenesis.

scholarly journals The Polycomb group protein RING1B is overexpressed in ductal breast carcinoma and is required to sustain FAK steady state levels in breast cancer epithelial cells

Oncotarget ◽  
2014 ◽  
Vol 5 (8) ◽  
pp. 2065-2076 ◽  
Author(s):  
Almudena Bosch ◽  
Konstantina Panoutsopoulou ◽  
Josep Maria Corominas ◽  
Ramón Gimeno ◽  
Gema Moreno-Bueno ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Steady State ◽  
Breast Carcinoma ◽  
Epithelial Cells ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Ductal Breast Carcinoma ◽  
Group Protein ◽  
Steady State Levels

scholarly journals Polycomb group protein EZH2 is frequently expressed in inflammatory breast cancer and is predictive of worse clinical outcome

Cancer ◽  
2011 ◽  
Vol 117 (24) ◽  
pp. 5476-5484 ◽  
Author(s):  
Yun Gong ◽  
Lei Huo ◽  
Ping Liu ◽  
Nour Sneige ◽  
Xiaoping Sun ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Outcome ◽  
Inflammatory Breast Cancer ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Group Protein
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