The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer

2006 ◽  
Vol 37 (5-7) ◽  
pp. 219-223 ◽  
Author(s):  
Michael Zeidler ◽  
Celina G. Kleer
Keyword(s):  
Breast Cancer ◽  
Dna Repair ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Enhancer Of Zeste ◽  
Group Protein

scholarly journals Enhancer of Zeste Homolog 2 Overexpression Has a Role in the Development of Anaplastic Thyroid Carcinomas

2011 ◽  
Vol 96 (4) ◽  
pp. 1029-1038 ◽  
Author(s):  
Eleonora Borbone ◽  
Giancarlo Troncone ◽  
Angelo Ferraro ◽  
Zuzana Jasencakova ◽  
Lovorka Stojic ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Anaplastic Thyroid Carcinoma ◽  
Polycomb Group ◽  
Migration And Invasion ◽  
Polycomb Group Protein ◽  
Expression Levels ◽  
Thyroid Carcinomas ◽  
Enhancer Of Zeste ◽  
Pax8 Gene ◽  
Group Protein

Abstract Context: Enhancer of zeste homolog 2 (EZH2) is a histone lysine methyltransferase belonging to the polycomb group protein family. Overexpression of EZH2 has been found in several human malignancies including hematological and solid tumors. Objectives: In this study we investigated the expression levels of EZH2 and its polycomb group protein partners in thyroid carcinoma tissues with different degrees of malignancy to identify potential new therapeutic targets for anaplastic thyroid carcinoma (ATC). Results: We show that high EZH2 expression levels are characteristic of undifferentiated ATC, whereas no significant changes were observed in well-differentiated papillary and follicular thyroid carcinomas as compared with normal thyroid. Knockdown of EZH2 in ATC cell lines results in cell growth inhibition, loss of anchorage-independent growth, migration, and invasion properties. Moreover, we demonstrate that EZH2 directly controls differentiation of ATC cells by silencing the thyroid specific transcription factor paired-box gene 8 (PAX8). Conclusions: EZH2 is specifically overexpressed in ATC, and it directly contributes to transcriptional silencing of PAX8 gene and ATC differentiation.

Expression Profile of the Polycomb Group Protein Enhancer of Zeste Homologue 2 and its Prognostic Relevance in Renal Cell Carcinoma

2009 ◽  
Vol 182 (6) ◽  
pp. 2920-2925 ◽  
Author(s):  
Stefan Hinz ◽  
Steffen Weikert ◽  
Ahmed Magheli ◽  
Michèle Hoffmann ◽  
Rainer Engers ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Expression Profile ◽  
Renal Cell ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Prognostic Relevance ◽  
Enhancer Of Zeste ◽  
Group Protein

scholarly journals The Polycomb Group Protein EZH2 Impairs DNA Repair in Breast Epithelial Cells

Neoplasia ◽  
2005 ◽  
Vol 7 (11) ◽  
pp. 1011-1019 ◽  
Author(s):  
Michael Zeidler ◽  
Sooryanarayana Varambally ◽  
Qi Cao ◽  
Arul M. Chinnaiyan ◽  
David O. Ferguson ◽  
...  
Keyword(s):  
Dna Repair ◽  
Epithelial Cells ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Breast Epithelial Cells ◽  
Group Protein ◽  
Breast Epithelial

scholarly journals The Role of Polycomb Group Protein BMI1 in DNA Repair and Genomic Stability

2021 ◽  
Vol 22 (6) ◽  
pp. 2976
Author(s):  
Amira Fitieh ◽  
Andrew J. Locke ◽  
Mobina Motamedi ◽  
Ismail Hassan Ismail
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Gene Silencing ◽  
Strand Break ◽  
Polycomb Group ◽  
Polycomb Group Protein ◽  
Post Translational Modifications ◽  
Dna Damage Signaling ◽  
Dna Double Strand Break ◽  
Group Protein

The polycomb group (PcG) proteins are a class of transcriptional repressors that mediate gene silencing through histone post-translational modifications. They are involved in the maintenance of stem cell self-renewal and proliferation, processes that are often dysregulated in cancer. Apart from their canonical functions in epigenetic gene silencing, several studies have uncovered a function for PcG proteins in DNA damage signaling and repair. In particular, members of the poly-comb group complexes (PRC) 1 and 2 have been shown to recruit to sites of DNA damage and mediate DNA double-strand break repair. Here, we review current understanding of the PRCs and their roles in cancer development. We then focus on the PRC1 member BMI1, discussing the current state of knowledge of its role in DNA repair and genome integrity, and outline how it can be targeted pharmacologically.

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