Associations between Pre-Adolescents’ Cognitive Responses to Alcohol Cues, Maternal Drinking, and Direct Exposure to Alcohol

Alcohol ◽  
2021 ◽  
Author(s):  
Catherine A. Forestell ◽  
Cheryl L. Dickter ◽  
Lauren Collier-Spruel
Author(s):  
J. K. Maurin

Conductor, resistor, and dielectric patterns of microelectronic device are usually defined by exposure of a photosensitive material through a mask onto the device with subsequent development of the photoresist and chemical removal of the undesired materials. Standard optical techniques are limited and electron lithography provides several important advantages, including the ability to expose features as small as 1,000 Å, and direct exposure on the wafer with no intermediate mask. This presentation is intended to report how electron lithography was used to define the permalloy patterns which are used to manipulate domains in magnetic bubble memory devices.The electron optical system used in our experiment as shown in Fig. 1 consisted of a high resolution scanning electron microscope, a computer, and a high precision motorized specimen stage. The computer is appropriately interfaced to address the electron beam, control beam exposure, and move the specimen stage.


2020 ◽  
Vol 12 (4) ◽  
pp. 471-474
Author(s):  
Elizabeth J. Parks-Stamm ◽  
Jeremy S. Pollack ◽  
Darlene R. Hill

Author(s):  
Maitane GARCÍA-LÓPEZ ◽  
Ester VAL ◽  
Ion IRIARTE ◽  
Raquel OLARTE

Taking patient experience as a basis, this paper introduces a theoretical framework, to capture insights leading to new technological healthcare solutions. Targeting a recently diagnosed type 1 diabetes child and her mother (the principal caregiver), the framework showed its potential with effective identification of meaningful insights in a generative session. The framework is based on the patient experience across the continuum of care. It identifies insights from the patient perspective: capturing patients´ emotional and cognitive responses, understanding agents involved in patient experience, uncovering pain moments, identifying their root causes, and/or prioritizing actions for improvement. The framework deepens understanding of the patient experience by providing an integrated and multi-leveled structure to assist designers to (a) empathise with the patient and the caregiver throughout the continuum of care, (b) understand the interdependencies around the patient and different agents and (c) reveal insights at the interaction level.


Author(s):  
Rakesh Kumar Gulati ◽  
Manveen Kaur

Information and Communications Technologies (ICTs) adoption is increasing globally for human development because of its potential affect in many aspects of economic and societal activities such as GDP growth, employment, productivity, poverty alleviation, quality of life, education, clean water and sanitation, clean energy, and healthcare. Adoption of new technologies has been the main challenge in rural areas and is the main reason for the growing gap between rural and urban economy. The work related ICT use have also yielded mixed results; some studies show the individual’s perceived work-family conflict, negative cognitive responses e.g. techno stress while others show increased productivity, improved job satisfaction and work-family balance due to flexible work timings. This paper attempts to understand the role of ICT in human development areas of health, education and citizen empowerment taking into consideration of digital divide which exists in geographic area and within the communities through literature review.


2019 ◽  
Author(s):  
Alexander Lane Williams ◽  
Christopher C Conway

Clinically significant fears and phobias can be acquired vicariously. Witnessing a demonstrator’s defensive reaction to potentially dangerous objects and situations can instill conditioned threat responses in the observer. The present study concentrates on individual differences in this social learning process. Specifically, we hypothesized that dispositional empathy modulates vicarious threat conditioning. We examined university students’ (N = 150) conditioned threat responding after they observed strangers undergo Pavlovian threat conditioning. There was evidence of a substantial conditioned defensive response (Cohen’s d = 0.66), as indexed by elevated skin conductance reactions during participants’ direct exposure to the vicariously conditioned stimuli. Contrary to expectations, indices of dispositional empathy were weakly related to the size of conditioned responses (median r = .04). Our results confirm that vicarious threat learning can be evaluated experimentally, but they do not support the hypothesis that empathy amplifies this process. The preregistration, stimulus materials, data, and analysis code for this study are available at https://osf.io/h6hm2.


2021 ◽  
Author(s):  
Paulo A S Kadri ◽  
Walid I B N Essayed ◽  
Ossama Al-Mefty

Abstract The pons is the most frequent local for brain stem cavernoma.1 Repeated hemorrhage of brainstem cavernoma is associated with significant and accumulative neurological deficits and thus requires treatment. According to the Swedish Karolinska’s group of radiosurgery, ”it could not be concluded whether GKRS affects the natural course of a CM. The incidence of radiation-induced complications was approximately seven times higher than that expected.”2 Thus, microsurgical removal has become the mainstay of treatment. In our experience, the following details assist in obtaining favorable outcomes and avoiding postoperative complications3,4: (a) the entry into the cavernoma based on thorough knowledge of the microanatomy; (b) the detailed study of the images and the presentation of the cavernoma on or near the brain stem surface; (c) the resection of the live cavernous hemangioma and not the mere removal of the multiple aged organized hematomas; (d) the preservation of the associated venous angioma; (e) the direct and shortest access to the lesion provided by a skull base approach; and (f) the use of the available technology, such as intraoperative neuromonitoring and neuroimaging. We present the case of a 54-yr-old male with recent deterioration in year 2001, past repetitive episodes of gait imbalance, and speech difficulty over a 7-yr period from known pontine cavernoma. The anterior petrosal approach provided superb and direct exposure to the entry at the lateral pons and the cavernoma was totally removed with preservation of the venous angioma. His preoperative neurological deficit rapidly recovered. Patient consented to the procedure and photography. Images at 3:15 from Kadri et al, The anatomical basis for surgical presercation of temporal muscle. J Neurosurg. 2004;100:517-522, used with permission from JNSPG. Image at 3:27 from Al-Mefty O, Operative Atlas of Meningiomas, © LWW, 1997, with permission.


2021 ◽  
Vol 7 (15) ◽  
pp. eabf6780
Author(s):  
Corinde E. Wiers ◽  
Leandro F. Vendruscolo ◽  
Jan-Willem van der Veen ◽  
Peter Manza ◽  
Ehsan Shokri-Kojori ◽  
...  

Individuals with alcohol use disorder (AUD) show elevated brain metabolism of acetate at the expense of glucose. We hypothesized that a shift in energy substrates during withdrawal may contribute to withdrawal severity and neurotoxicity in AUD and that a ketogenic diet (KD) may mitigate these effects. We found that inpatients with AUD randomized to receive KD (n = 19) required fewer benzodiazepines during the first week of detoxification, in comparison to those receiving a standard American (SA) diet (n = 14). Over a 3-week treatment, KD compared to SA showed lower “wanting” and increased dorsal anterior cingulate cortex (dACC) reactivity to alcohol cues and altered dACC bioenergetics (i.e., elevated ketones and glutamate and lower neuroinflammatory markers). In a rat model of alcohol dependence, a history of KD reduced alcohol consumption. We provide clinical and preclinical evidence for beneficial effects of KD on managing alcohol withdrawal and on reducing alcohol drinking.


Author(s):  
Roberto A. Sussman ◽  
Eliana Golberstein ◽  
Riccardo Polosa

We discuss the implications of possible contagion of COVID-19 through e-cigarette aerosol (ECA) for prevention and mitigation strategies during the current pandemic. This is a relevant issue when millions of vapers (and smokers) must remain under indoor confinement and/or share public outdoor spaces with non-users. The fact that the respiratory flow associated with vaping is visible (as opposed to other respiratory activities) clearly delineates a safety distance of 1–2 m along the exhaled jet to prevent direct exposure. Vaping is a relatively infrequent and intermittent respiratory activity for which we infer a mean emission rate of 79.82 droplets per puff (6–200, standard deviation 74.66) comparable to mouth breathing, it adds into shared indoor spaces (home and restaurant scenarios) a 1% extra risk of indirect COVID-19 contagion with respect to a “control case” of existing unavoidable risk from continuous breathing. As a comparative reference, this added relative risk increases to 44–176% for speaking 6–24 min per hour and 260% for coughing every 2 min. Mechanical ventilation decreases absolute emission levels but keeps the same relative risks. As long as direct exposure to the visible exhaled jet is avoided, wearing of face masks effectively protects bystanders and keeps risk estimates very low. As a consequence, protection from possible COVID-19 contagion through vaping emissions does not require extra interventions besides the standard recommendations to the general population: keeping a social separation distance of 2 m and wearing of face masks.


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