Information for CME Credit—Physical Activity and Anxiety A Systematic Review and Meta-analysis of Prospective Cohort Studies

ObjectiveTo explore whether physical activity is inversely associated with the onset of depression, we quantified the cumulative association of customary physical activity with incident depression and with an increase in subclinical depressive symptoms over time as reported from prospective observational studies.DesignSystematic review and meta-analysis.Data sourcesMEDLINE, PsycINFO, PsycARTICLES and CINAHL Complete databases, supplemented by Google Scholar.Eligibility criteriaProspective cohort studies in adults, published prior to January 2020, reporting associations between physical activity and depression.Study appraisal and synthesisMultilevel random-effects meta-analysis was performed adjusting for study and cohort or region. Mixed-model meta-regression of putative modifiers.ResultsSearches yielded 111 reports including over 3 million adults sampled from 11 nations in five continents. Odds of incident cases of depression or an increase in subclinical depressive symptoms were reduced after exposure to physical activity (OR, 95% CI) in crude (0.69, 0.63 to 0.75; I2=93.7) and adjusted (0.79, 0.75 to 0.82; I2=87.6) analyses. Results were materially the same for incident depression and subclinical symptoms. Odds were lower after moderate or vigorous physical activity that met public health guidelines than after light physical activity. These odds were also lower when exposure to physical activity increased over time during a study period compared with the odds when physical activity was captured as a single baseline measure of exposure.ConclusionCustomary and increasing levels of moderate-to-vigorous physical activity in observational studies are inversely associated with incident depression and the onset of subclinical depressive symptoms among adults regardless of global region, gender, age or follow-up period.

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Determining the association between physical activity prior to conception and pregnancy rate: A systematic review and meta-analysis of prospective cohort studies

Health Care For Women International ◽

10.1080/07399332.2019.1640701 ◽

2019 ◽

Vol 41 (1) ◽

pp. 38-53 ◽

Cited By ~ 1

Author(s):

Junga Lee

Keyword(s):

Physical Activity ◽

Systematic Review ◽

Cohort Studies ◽

Pregnancy Rate ◽

Prospective Cohort ◽

Meta Analysis ◽

Prospective Cohort Studies

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The association between physical activity and risk of falling in older adults: A systematic review and meta-analysis of prospective cohort studies

Geriatric Nursing ◽

10.1016/j.gerinurse.2020.05.005 ◽

2020 ◽

Vol 41 (6) ◽

pp. 747-753

Author(s):

Junga Lee

Keyword(s):

Physical Activity ◽

Systematic Review ◽

Older Adults ◽

Cohort Studies ◽

Prospective Cohort ◽

Meta Analysis ◽

Risk Of Falling ◽

Prospective Cohort Studies

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Physical activity and risk of venous thromboembolism: systematic review and meta-analysis of prospective cohort studies

European Journal of Epidemiology ◽

10.1007/s10654-019-00579-2 ◽

2019 ◽

Vol 35 (5) ◽

pp. 431-442 ◽

Cited By ~ 10

Author(s):

Setor K. Kunutsor ◽

Timo H. Mäkikallio ◽

Samuel Seidu ◽

Claudio Gil Soares de Araújo ◽

Richard S. Dey ◽

...

Keyword(s):

Physical Activity ◽

Systematic Review ◽

Venous Thromboembolism ◽

Cohort Studies ◽

Prospective Cohort ◽

Meta Analysis ◽

Minimal Amount ◽

Inverse Association ◽

Physically Active ◽

Prospective Cohort Studies

AbstractThe inverse association between physical activity and arterial thrombotic disease is well established. Evidence on the association between physical activity and venous thromboembolism (VTE) is divergent. We conducted a systematic review and meta-analysis of published observational prospective cohort studies evaluating the associations of physical activity with VTE risk. MEDLINE, Embase, Web of Science, and manual search of relevant bibliographies were systematically searched until 26 February 2019. Extracted relative risks (RRs) with 95% confidence intervals (CIs) for the maximum versus minimal amount of physical activity groups were pooled using random effects meta-analysis. Twelve articles based on 14 unique prospective cohort studies comprising of 1,286,295 participants and 23,753 VTE events were eligible. The pooled fully-adjusted RR (95% CI) of VTE comparing the most physically active versus the least physically active groups was 0.87 (0.79–0.95). In pooled analysis of 10 studies (288,043 participants and 7069 VTE events) that reported risk estimates not adjusted for body mass index (BMI), the RR (95% CI) of VTE was 0.81 (0.70–0.93). The associations did not vary by geographical location, age, sex, BMI, and methodological quality of studies. There was no evidence of publication bias among contributing studies. Pooled observational prospective cohort studies support an association between regular physical activity and low incidence of VTE. The relationship does not appear to be mediated or confounded by BMI.

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