scholarly journals Physical activity and risk of venous thromboembolism: systematic review and meta-analysis of prospective cohort studies

2019 ◽  
Vol 35 (5) ◽  
pp. 431-442 ◽  
Author(s):  
Setor K. Kunutsor ◽  
Timo H. Mäkikallio ◽  
Samuel Seidu ◽  
Claudio Gil Soares de Araújo ◽  
Richard S. Dey ◽  
...  
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Venous Thromboembolism ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Minimal Amount ◽  
Inverse Association ◽  
Physically Active ◽  
Prospective Cohort Studies

AbstractThe inverse association between physical activity and arterial thrombotic disease is well established. Evidence on the association between physical activity and venous thromboembolism (VTE) is divergent. We conducted a systematic review and meta-analysis of published observational prospective cohort studies evaluating the associations of physical activity with VTE risk. MEDLINE, Embase, Web of Science, and manual search of relevant bibliographies were systematically searched until 26 February 2019. Extracted relative risks (RRs) with 95% confidence intervals (CIs) for the maximum versus minimal amount of physical activity groups were pooled using random effects meta-analysis. Twelve articles based on 14 unique prospective cohort studies comprising of 1,286,295 participants and 23,753 VTE events were eligible. The pooled fully-adjusted RR (95% CI) of VTE comparing the most physically active versus the least physically active groups was 0.87 (0.79–0.95). In pooled analysis of 10 studies (288,043 participants and 7069 VTE events) that reported risk estimates not adjusted for body mass index (BMI), the RR (95% CI) of VTE was 0.81 (0.70–0.93). The associations did not vary by geographical location, age, sex, BMI, and methodological quality of studies. There was no evidence of publication bias among contributing studies. Pooled observational prospective cohort studies support an association between regular physical activity and low incidence of VTE. The relationship does not appear to be mediated or confounded by BMI.

scholarly journals Customary physical activity and odds of depression: a systematic review and meta-analysis of 111 prospective cohort studies

2021 ◽  
pp. bjsports-2020-103140
Author(s):  
Rodney K Dishman ◽  
Cillian P McDowell ◽  
Matthew Payton Herring
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Depressive Symptoms ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Observational Studies ◽  
Meta Analysis ◽  
Vigorous Physical Activity ◽  
Prospective Cohort Studies ◽  
Over Time

ObjectiveTo explore whether physical activity is inversely associated with the onset of depression, we quantified the cumulative association of customary physical activity with incident depression and with an increase in subclinical depressive symptoms over time as reported from prospective observational studies.DesignSystematic review and meta-analysis.Data sourcesMEDLINE, PsycINFO, PsycARTICLES and CINAHL Complete databases, supplemented by Google Scholar.Eligibility criteriaProspective cohort studies in adults, published prior to January 2020, reporting associations between physical activity and depression.Study appraisal and synthesisMultilevel random-effects meta-analysis was performed adjusting for study and cohort or region. Mixed-model meta-regression of putative modifiers.ResultsSearches yielded 111 reports including over 3 million adults sampled from 11 nations in five continents. Odds of incident cases of depression or an increase in subclinical depressive symptoms were reduced after exposure to physical activity (OR, 95% CI) in crude (0.69, 0.63 to 0.75; I2=93.7) and adjusted (0.79, 0.75 to 0.82; I2=87.6) analyses. Results were materially the same for incident depression and subclinical symptoms. Odds were lower after moderate or vigorous physical activity that met public health guidelines than after light physical activity. These odds were also lower when exposure to physical activity increased over time during a study period compared with the odds when physical activity was captured as a single baseline measure of exposure.ConclusionCustomary and increasing levels of moderate-to-vigorous physical activity in observational studies are inversely associated with incident depression and the onset of subclinical depressive symptoms among adults regardless of global region, gender, age or follow-up period.

scholarly journals Physical Activity For Multimorbidity Prevention And Management: A Systematic Review of Longitudinal Prospective Studies

2021 ◽  
Author(s):  
Danielle Hargan ◽  
Dáire McCartan ◽  
Leandro M. T. Garcia
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Data Extraction ◽  
Current Evidence ◽  
Randomised Control Trial ◽  
Physically Active ◽  
Prospective Cohort Studies ◽  
Current Evidence Base

Abstract Background: The objective of this study was to determine whether physical activity can be used in the prevention and management of multimorbidity.Methods: A systematic review was carried out using Pubmed, Web of Science, EMBASE, and Scopus databases to find experimental and prospective cohort studies that investigated the relationship between physical activity and prevention and management of multimorbidity. Participants consisted of general population, non-institutionalised adults aged 18 or more. Screening, data extraction, and risk of bias assessment were conducted by two independent reviewers.Results: From a total of 1,724 studies identified, eight prospective cohort studies and one randomised control trial were included in the analysis. Four out of nine studies found evidence that higher levels of physical activity reduced the risk of multimorbidity. Three of four studies found evidence that physical activity reduces the risk of developing or worsening multimorbidity within subgroups with chronic conditions at the baseline.Conclusion: The current evidence base indicates that it is unclear whether healthy individuals are more likely to develop multimorbidity if they are less physically active. However, it seems more likely for people to develop or worsen multimorbidity when they have one or any number of conditions at baseline if they are less physically active.

Physical Activity and Anxiety: A Systematic Review and Meta-analysis of Prospective Cohort Studies

2019 ◽  
Vol 57 (4) ◽  
pp. 545-556 ◽  
Author(s):  
Cillian P. McDowell ◽  
Rodney K. Dishman ◽  
Brett R. Gordon ◽  
Matthew P. Herring
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Cohort Studies ◽  
Prospective Cohort ◽  
Meta Analysis ◽  
Prospective Cohort Studies
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