Dipstick Proteinuria and Reduced Estimated Glomerular Filtration Rate as Independent Risk Factors for Osteoporosis

2018 ◽  
Vol 355 (5) ◽  
pp. 434-441 ◽  
Author(s):  
Chun-Wu Tung ◽  
Yung-Chien Hsu ◽  
Ya-Hsueh Shih ◽  
Pey-Jium Chang ◽  
Chun-Liang Lin
Keyword(s):  
Risk Factors ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Independent Risk Factors

scholarly journals Combined Effects of Dyslipidemia and Obesity Parameters on The Estimated Glomerular Filtration Rate in a Middle-Aged Population

2021 ◽  
Author(s):  
Xichang Wang ◽  
Haoyu Wang ◽  
Xiaotong Gao ◽  
Yutong Han ◽  
Weiping Teng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Subcutaneous Fat ◽  
The Body ◽  
Combined Effects ◽  
Independent Risk Factors ◽  
Obesity Indices

Abstract BackgroundSome studies have reported that chronic kidney disease (CKD) or the estimated glomerular filtration rate (eGFR) is significantly associated with metabolic-related parameters, such as dyslipidemia and obesity. However, whether eGFR will change under the superposition of multiple specific metabolic indicators remains unclear.MethodsSix hundred forty-six community residents aged 45–60 years without overt renal dysfunction were recruited in this cross-sectional study. eGFR was calculated by measuring serum creatinine. The visceral fat area (VFA) and subcutaneous fat area (SFA) were assessed by magnetic resonance imaging (MRI). The body mass index (BMI) and waist-hip ratio (WHR) were also evaluated. Additionally, we tested the subjects' blood lipid levels to diagnose dyslipidemia.ResultsCompared with the subjects with neither dyslipidemia nor obesity, men with both dyslipidemia and high obesity indices, such as BMI, WHR and VFA, showed a significantly lower mean eGFR; women with dyslipidemia with high WHR, VFA or SFA also showed a significantly lower mean eGFR. With the superposition of dyslipidemia and obesity indices such as BMI and SFA, the eGFR level showed a significant decreasing trend in men; the eGFR level also showed a significant decreasing trend in women but with the superposition of dyslipidemia plus WHR or SFA. Although an independent association between metabolic variables and eGFR was not found except for BMI, some of the combined effects of each variable were related to eGFR decline. Double positivity for dyslipidemia and high obesity indices such as BMI and VFA were significant independent risk factors for eGFR reduction in men. Additionally, double positivity for dyslipidemia and high WHR were significant independent risk factors for eGFR reduction overall.ConclusionsThe combined effect of dyslipidemia and high obesity indices is significantly related to the decline in eGFR. The association is more profound in men.

scholarly journals Microalbuminuria risks and glomerular filtration in children with sickle cell anaemia in Nigeria

2019 ◽  
Vol 45 (1) ◽  
Author(s):  
I. E. Ocheke ◽  
S. Mohamed ◽  
E. S. Okpe ◽  
F. Bode-Thomas ◽  
M. I. McCullouch
Keyword(s):  
Risk Factors ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Sickle Cell ◽  
Filtration Rate ◽  
Sickle Cell Anaemia ◽  
Estimated Glomerular Filtration Rate ◽  
Kidney Damage ◽  
Strong Positive Correlation ◽  
Cross Sectional

Abstract Introduction Evidence of kidney damage is observed in children with sickle cell anaemia (SCA) and this continues through adulthood with progression to severe functional impairment in some. One of the earliest features of kidney damage associated with SCA is microalbuminuria. Our objective was to determine the risk factors of microalbuminuria in these children and its relationship with estimated glomerular filtration rate. Methods This was a cross-sectional and comparative study involving three hundred and twenty three children with SCA in steady state and equal numbers of apparently healthy age and sex matched haemoglobin AA (HbAA) control, aged 6 months to 18 years. They were consecutively recruited over a 6 month period. Result Microalbuminuria was present in 26% of the study subjects compared with 1.85% of control P = 0.001). Anaemia and high estimated glomerular filtration rate (eGFR) showed strong positive correlation with microalbuminuria (OR = 3.19, CI 0.953–1.116, p = 0.003 and OR = 1.7, CI 1.042–1.066, p = 0.001 respectively). Similarly, eGFR was higher in subjects with SCA than in controls and as well as in those with microalbuminuria compared with those who do not (p = < 0.01). Conclusions The two most important risk factors for microalbuminuria were anaemia and high eGFR. Age category was associated more with microalbuminuria than just age as a variable. Glomerular filtration rate was higher in children with microalbuminuria than those who do not and it was also higher in children with SCA than in control.

scholarly journals Association of Kidney Function Tests with a Cardio-Ankle Vascular Index in Community-Dwelling Individuals with a Normal or Mildly Decreased Estimated Glomerular Filtration Rate

Medicina ◽  
2019 ◽  
Vol 55 (10) ◽  
pp. 657 ◽  
Author(s):  
Javad Alizargar ◽  
Chyi-Huey Bai ◽  
Nan-Chen Hsieh ◽  
Shu-Fang Vivienne Wu ◽  
Shih-Yen Weng ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Glomerular Filtration Rate ◽  
Arterial Stiffness ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Community Dwelling ◽  
Atherosclerosis Risk ◽  
Atherosclerosis Risk Factors

Background and objectives: Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease (CVD). Previous studies reported controversial results about the independence of CKD as a risk factor for atherosclerosis. In this study, we tried to determine whether the estimated glomerular filtration rate (eGFR) and other renal function tests are independent factors associated with arterial stiffness in community-dwelling individuals with a normal (≥90) or slightly decreased eGFR (60-90). Materials and Methods: Data of 164 community individuals were analyzed, and demographic information, related disease history, atherosclerosis risk factors, certain laboratory tests, the estimated eGFR, and urine albumin creatinine ratio (UACR) were recorded for each individual. Results: The age, systolic blood pressure (SBP), hypertension (HTN), and cardio-ankle vascular index (CAVI) significantly differed between individuals with a normal and those with a slightly decreased eGFR. Blood urea nitrogen (BUN), glycated hemoglobin (HBA1c), and the eGFR significantly differed between the high- and low-CAVI groups and were also significantly correlated with the CAVI. The relationship between the eGFR and CAVI was shown to be independent of other atherosclerosis risk factors in a multiple linear regression model. Conclusions: We concluded that evaluations of the eGFR, HTN, body-mass index, and SBP can be used in a model for arterial stiffness risk assessments for community-dwelling individuals with a normal or slightly decreased eGFR.

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