The Expression of Aquaporin-1 and Aquaporin-3 in Extrahepatic Cholangiocarcinoma and their Clinicopathological Significance

2021 ◽  
Author(s):  
Shu Xu ◽  
Shengfu Huang ◽  
Daiqiang Li ◽  
Qiong Zou ◽  
Yuan Yuan ◽  
...  
Keyword(s):  
Extrahepatic Cholangiocarcinoma ◽  
Aquaporin 3 ◽  
Aquaporin 1 ◽  
Clinicopathological Significance

Expression Pattern of Aquaporin 1 and Aquaporin 3 in Melanocytic and Nonmelanocytic Skin Tumors

2019 ◽  
Vol 152 (4) ◽  
pp. 446-457 ◽  
Author(s):  
Giovana Osorio ◽  
Teresa Zulueta-Dorado ◽  
Patricia González-Rodríguez ◽  
José Bernabéu-Wittel ◽  
Julian Conejo-Mir ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Skin Tumors ◽  
Aquaporin 3 ◽  
Melanocytic Nevi ◽  
Aquaporin 1 ◽  
Melanocytic Tumors ◽  
Basal Cell Carcinomas ◽  
Molecular Therapeutic ◽  
Molecular Therapeutic Targets ◽  
Atypical Nevi

Abstract Objectives Study of aquaporin 1 (AQP1) and aquaporin 3 (AQP3) expression to understand its potential role in the pathophysiology of skin cancer. Methods Analysis of AQP1 and AQP3 expression by immunohistochemistry of 72 skin biopsy specimens from melanocytic skin tumors, nonmelanocytic tumors, or healthy samples. Results AQP1 showed strong labeling in 100% of benign common melanocytic nevi. Small blood vessels, stroma, and melanophages surrounding different types of melanomas tumors also were positive. Tumoral melanocytes in atypical nevi and melanomas were negative for AQP1. AQP3 showed strong labeling in 100% of melanocytic nevi, 100% of atypical melanocytic nevi, and 100% of melanomas. In all basal cell carcinomas and squamous cell carcinomas, staining for AQP3 was positive. Conclusions To our knowledge, this work represents the first demonstration of AQP1/AQP3 expression in human melanocytic skin tumors. More studies are needed to understand the underlying molecular mechanisms of expression of both AQPs in melanocytic tumors and their potential as molecular therapeutic targets.

scholarly journals Aquaporin 1, Aquaporin 3 and Aquaporin 5 expression and EGFR mutation in malignant pleural mesotheliomas: an imunohistochemical and molecular study

2016 ◽  
Vol 31 (2) ◽  
pp. 367-372
Author(s):  
Ulaş Alabalık ◽  
Gül Türkcü ◽  
Ayşe Nur Keleş ◽  
İbrahim İbiloğlu ◽  
Zuhat Urakçı ◽  
...  
Keyword(s):  
Egfr Mutation ◽  
Molecular Study ◽  
Aquaporin 5 ◽  
Aquaporin 3 ◽  
Aquaporin 1

Increased Expression of Aquaporin-1 and Aquaporin-3 in Pterygium

Cornea ◽  
2013 ◽  
Vol 32 (10) ◽  
pp. 1375-1379 ◽  
Author(s):  
Huseyin Ortak ◽  
Sevil Cayli ◽  
Seda Ocakli ◽  
Selim Demir
Keyword(s):  
Aquaporin 3 ◽  
Aquaporin 1

Comparison of ADAM19 and CUEDC2 expression in EHCC and their clinicopathological significance

2020 ◽  
Vol 14 (16) ◽  
pp. 1573-1584
Author(s):  
Shu Xu ◽  
Shengfu Huang ◽  
Daiqiang Li ◽  
Qiong Zou ◽  
Yuan Yuan ◽  
...  
Keyword(s):  
Overall Survival ◽  
Prognostic Factors ◽  
Survival Time ◽  
Biliary Tract ◽  
Extrahepatic Cholangiocarcinoma ◽  
Positive Correlation ◽  
Overall Survival Time ◽  
Positive Expression ◽  
Dismal Prognosis ◽  
Clinicopathological Significance

Background: To evaluate the expression and clinicopathological significance of a disintegrin and metalloproteinases 19 (ADAM19) CUE domain containing protein 2 (CUEDC2) in extrahepatic cholangiocarcinoma (EHCC). Materials & methods: Immunostaining of ADAM19 and CUEDC2 was performed by EnVision immunohistochemistry in benign and malignant biliary tract tissues. Result: The expression of ADAM19 and CUEDC2 were significantly higher in EHCC (p < 0.05). ADAM19 expression was positive correlated with CUEDC2 expression in EHCC (p < 0.05). The overall survival time of those with positive expression of ADAM19 and CUEDC2 was lower (p < 0.001). Both positive expression of ADAM19 and CUEDC2 were independent prognostic factors in EHCC. Conclusion: ADAM19 and CUEDC2 have a positive correlation to the pathogenesis and dismal prognosis in EHCC.

scholarly journals Aquaporin 1 and 3 as local vitality markers in mechanical and thermal skin injuries

2021 ◽  
Author(s):  
Julian Prangenberg ◽  
E. Doberentz ◽  
A. -L. Witte ◽  
B. Madea
Keyword(s):  
Gunshot Wounds ◽  
Mean Value ◽  
Epidermal Keratinocytes ◽  
Skin Injury ◽  
Aquaporin 3 ◽  
Aquaporin 1 ◽  
Sharp Force ◽  
Trauma Injury ◽  
Age Range ◽  
Aquaporin Channels

AbstractAssessment of the vitality of an injury is one of to the main tasks in daily forensic casework. Aquaporins belong to the family of water channels. They enable the transport of water and of small molecules like glycerol through biological channels. So far, 13 classes of aquaporins are identified in vertebrates. The classical aquaporin channels 1, 2 and 4 are only permeable for water. The aquaporin channels 3, 7, 9 and 10 are also called aquaglycerolporins since they can also transport glycerol. Aquaporin 3 is expressed in epidermal keratinocytes. In the present investigation, the aquaporin 1 and 3 expression in mechanically and thermally damaged skin is investigated by immunohistochemistry. The study collective comprises 30 cases (63.3% male and 36.7% female) with an age range between 19 and 95 years (mean value 54.6 years). The skin injury comprises different kinds of blunt force, sharp force, strangulation marks, thermal injury, gunshot wounds and frost erythema. In all kinds of mechanical and trauma injury, an increased expression of aquaporin 3 in the keratinocytes of the epidermis was found. There is no correlation of the aquaporin 3 expression with age, sex, body mass index, duration of agonal period and postmortem interval. Concerning aquaporin 1, there were no differences between injured and uninjured skin. Aquaporin 3 is independently from the kind of skin injury and appears to be a valuable immunohistochemical parameter of vitality.

scholarly journals The expression of gastrointestinal differentiation markers in extrahepatic cholangiocarcinoma: clinicopathological significance based on tumor location

2019 ◽  
Vol 92 ◽  
pp. 91-100
Author(s):  
Kazuyuki Ishida ◽  
Mitsumasa Osakabe ◽  
Makoto Eizuka ◽  
Seigo Tai ◽  
Ryo Sugimoto ◽  
...  
Keyword(s):  
Tumor Location ◽  
Differentiation Markers ◽  
Extrahepatic Cholangiocarcinoma ◽  
Clinicopathological Significance
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