Angiointervention: an independent predictor of survival in high-grade blunt liver injuries

2015 ◽  
Vol 209 (4) ◽  
pp. 742-746 ◽  
Author(s):  
Emre Sivrikoz ◽  
Pedro G. Teixeira ◽  
Shelby Resnick ◽  
Kenji Inaba ◽  
Peep Talving ◽  
...  
2001 ◽  
Vol 19 (13) ◽  
pp. 3203-3209 ◽  
Author(s):  
Fritz C. Eilber ◽  
Gerald Rosen ◽  
Jeffery Eckardt ◽  
Charles Forscher ◽  
Scott D. Nelson ◽  
...  

PURPOSE: To determine whether treatment-induced pathologic necrosis correlates with local recurrence and overall survival in patients who receive neoadjuvant therapy for high-grade extremity soft tissue sarcomas. PATIENTS AND METHODS: Four hundred ninety-six patients with intermediate- to high-grade extremity soft tissue sarcomas received protocol neoadjuvant therapy. All patients underwent surgical resection after neoadjuvant therapy and had pathologic assessment of tumor necrosis in the resected specimens. RESULTS: The 5- and 10-year local recurrence rates for patients with ≥ 95% pathologic necrosis were significantly lower (6% and 11%, respectively) than the local recurrence rates for patients with less than 95% pathologic necrosis (17% and 23%, respectively). The 5- and 10-year survival rates for the patients with ≥ 95% pathologic necrosis were significantly higher (80% and 71%, respectively) than the survival rates for the patients with less than 95% pathologic necrosis (62% and 55%, respectively). Patients with less than 95% pathologic necrosis were 2.51 times more likely to develop a local recurrence and 1.86 times more likely to die of their disease as compared with patients with ≥ 95% pathologic necrosis. The percentage of patients who achieved ≥ 95% pathologic necrosis increased to 48% with the addition of ifosfamide as compared with 13% of the patients in all the other protocols combined. CONCLUSION: Treatment-induced pathologic necrosis is an independent predictor of both local recurrence and overall survival in patients who receive neoadjuvant therapy for high-grade extremity soft tissue sarcomas. A complete pathologic response (≥ 95% pathologic necrosis) correlated with a significantly lower rate of local recurrence and improved overall survival.


2007 ◽  
Vol 0 (0) ◽  
pp. 070907021207002-???
Author(s):  
Phillip M. Pierorazio ◽  
Sarah M. Lambert ◽  
Mahesh Matsukhani ◽  
Preston C. Sprenkle ◽  
Tara R. McCann ◽  
...  

Author(s):  
Miklosh Bala ◽  
Samir Gazalla ◽  
Mohammad Faroja ◽  
Allan I Bloom ◽  
Gideon Zamir ◽  
...  
Keyword(s):  

2015 ◽  
Vol 16 (16) ◽  
pp. 7231-7235
Author(s):  
Chalita Kingnate ◽  
Amornrat Supoken ◽  
Pilaiwan Kleebkaow ◽  
Bundit Chumworathayi ◽  
Sanguanchoke Luanratanakorn ◽  
...  

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
M. J. Rutten ◽  
F. Dijk ◽  
C. D. Savci-Heijink ◽  
M. R. Buist ◽  
G. G. Kenter ◽  
...  

Aberrant expression of human leukocyte antigens (HLA) class I has prognostic importance in various cancers. Here, we evaluated the prognostic value of classical (A/B/C) and nonclassical (G/E) HLA expression in 169 high grade epithelial ovarian cancer samples and linked that to clinicopathological characteristics and survival. Expression of HLA-A, -B/C, or -E was not correlated with survival. Survival was prolonged when tumours expressed HLA-G(P=0.008)and HLA-G was an independent predictor for better survival(P=0.011). In addition, HLA-G expression was associated with longer progression-free survival(P=0.036)and response to chemotherapy(P=0.014). Accordingly, high expression of HLA-G mRNA was associated with prolonged disease-free survival(P=0.037)in 65 corresponding samples. Elevated serum-soluble HLA-G levels as measured by enzyme-linked immunosorbent assay in 50 matched patients were not correlated to HLA-G protein expression or gene expression nor with survival. During treatment, sHLA-G levels declined(P=0.038). In conclusion, expression of HLA-G is an independent prognostic factor for improved survival in high grade epithelial ovarian cancer and a predictor for platinum sensitivity.


2020 ◽  
Author(s):  
Sabah uddin Saqib ◽  
Wafa Iftekhar ◽  
Hasnain Zafar

Abstract Background: Liver injury occurs in approximately 5% of all trauma admissions. The large size of the liver and its location makes it more susceptible to injuries. Nowadays, the majority of isolated liver injuries are successfully managed with non-operative methods, however, operative management is still the mainstay of treatment for hemodynamically unstable patients. There are many traditional ways of controlling hemorrhage from the liver and here we report a case in which a GIA 75 stapler was successfully used to manage Grade IV liver injury in a hemodynamically unstable patient.Case presentation: 45 years old policeman presented in the emergency, within 20 minutes after sustaining a gunshot injury to his abdomen. At presentation, he was hemodynamically unstable with a heart rate of 100 beats/min and blood pressures of 70/35 mm Hg. On examination, he had a single entry wound in the epigastrium with no exit wound and had generalized peritonitis. He was paraplegic and had a sensory level. He was rushed to the operating room (OR) for exploratory laparotomy which revealed a shattered left lobe of the liver. Gastrointestinal anastomosis 75 stapler device was used for non-anatomical left segmentectomy (segments I and II). Active bleeding from tributaries of left hepatic vein and small branches opening into retrohepatic inferior vena cava (IVC) was identified and the vessels were suture ligated. Perihepatic packing was done and the patient shifted to the surgical intensive care unit(SICU). His improved hemodynamically and was re-explored within 24 hours. No active bleeding was seen after the packs were removed and the abdomen was closed. The next day he was moved out of SICU and the rehabilitation program was initiated for his spine injury. He was discharged on the 10th day of admission.Discussion: Grade IV liver injuries are often very complex and challenging to manage in a hemodynamically unstable patient. The role of GIA staplers for hepatic resection is quite common and safe in elective settings but their similar use in the context of trauma is less described. The concept of damage control surgery rests on quick control of life-threatening bleeding and a GIA stapler can be effectively used for rapid non-anatomical resection of the liver in trauma. This can prevent the depletion of physiological reserves and the life-threatening death triad. Conclusion: GIA stapler device is an effective, safe, and rapidly deployable tool for managing high grade live injury in a hemodynamically unstable patient. It controls bleeding without any concomitant chances of bile leak and also resection of the shattered liver gives good access for inspecting the rest of the bleeding sites.


2014 ◽  
Vol 191 (1) ◽  
pp. 28-34 ◽  
Author(s):  
Laura-Maria Krabbe ◽  
Aditya Bagrodia ◽  
Yair Lotan ◽  
Bishoy A. Gayed ◽  
Oussama M. Darwish ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document