scholarly journals Comparative effectiveness of treatment strategies for severe splenic trauma in the pediatric population

2016 ◽  
Vol 212 (4) ◽  
pp. 786-793 ◽  
Author(s):  
Kristy L. Rialon ◽  
Brian R. Englum ◽  
Brian C. Gulack ◽  
Carlos J. Guevara ◽  
Syamal D. Bhattacharya ◽  
...  
Keyword(s):  
Comparative Effectiveness ◽  
Pediatric Population ◽  
Treatment Strategies ◽  
Splenic Trauma

scholarly journals Paroxysmal Neuralgia in Pediatric Population- A Diagnostic Dilemma for Physicians and Dental Practioners

2014 ◽  
Vol 10 (4) ◽  
pp. 74-77 ◽  
Author(s):  
A Dubey ◽  
S Mujoo ◽  
SB Sakarde ◽  
AK Dubey
Keyword(s):  
Neuropathic Pain ◽  
Orofacial Pain ◽  
Pediatric Population ◽  
Treatment Strategies ◽  
Diagnostic Dilemma ◽  
Dental Pathology ◽  
Dental Intervention

Paroxysmal neuralgia is relatively uncommon in children. Neuropathic orofacial pain is a challenge for the clinician, as no obvious dental pathology exists either clinically or radiographically. Dentist and physician should be able to recognize the characteristics of neuropathic pain so as to correctly diagnose these conditions hence avoid unnecessary dental intervention. This article reviews the conditions with paroxysmal neuralgia in children and available treatment strategies. DOI: http://dx.doi.org/10.3126/kumj.v10i4.11000 Kathmandu Univ Med J 2012;10(4):74-77

Incorporating Immunotherapy Into the Treatment Strategies of B-Cell Adult Acute Lymphoblastic Leukemia: The Role of Blinatumomab and Inotuzumab Ozogamicin

2018 ◽  
pp. 574-578 ◽  
Author(s):  
Hagop Kantarjian ◽  
Elias Jabbour
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Pediatric Population ◽  
Lymphoblastic Leukemia ◽  
Treatment Strategies ◽  
Clinical Activity ◽  
Inotuzumab Ozogamicin ◽  
Term Survival ◽  
Drug Conjugates ◽  
Cure Rates

Monoclonal antibodies and bispecific antibody constructs hold considerable promise in improving the outcomes of patients with acute lymphoblastic leukemia (ALL). Antibody-drug conjugates such as inotuzumab ozogamicin and the bispecific T-cell engager blinatumomab represent novel antibody constructs that have shown substantial clinical activity in ALL. Although most studies have focused on the use of these agents in the salvage setting, incorporation of these antibodies into the frontline regimens is imperative to improve long-term survival for patients with ALL and to increase the cure rates of adult ALL to the levels achieved in the pediatric population.

scholarly journals Comparative effectiveness of long term drug treatment strategies to prevent asthma exacerbations: network meta-analysis

BMJ ◽  
2014 ◽  
Vol 348 (may13 3) ◽  
pp. g3009-g3009 ◽  
Author(s):  
R. J. B. Loymans ◽  
A. Gemperli ◽  
J. Cohen ◽  
S. M. Rubinstein ◽  
P. J. Sterk ◽  
...  
Keyword(s):  
Drug Treatment ◽  
Comparative Effectiveness ◽  
Meta Analysis ◽  
Treatment Strategies ◽  
Asthma Exacerbations

scholarly journals Neonatal Acute Paronychia

Hand ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. NP99-NP100 ◽  
Author(s):  
Luke Grome ◽  
Gregory Borah
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Pediatric Population ◽  
Treatment Strategies ◽  
Initial Therapy ◽  
Age Group ◽  
Predisposing Factor ◽  
Incision And Drainage ◽  
Amoxicillin Clavulanate ◽  
Neonatal Patient

Background: Paronychia is defined as infection afflicting the eponychial nail folds of the hand or foot. Such infections are rarely reported in the perinatal age group, and not previously described in a neonate younger than 2 weeks. Trauma resulting in inoculation of the nail fold is the most common predisposing factor to paronychia. Oral trauma in the pediatric population from finger sucking predisposes this population to a different set of bacterial pathogens than adults. Contamination can progress to infection and abscess formation within the nail fold with the most prevalent vector in adult infections being Staphylococcus aureus. Comparatively, mixed anaerobic and aerobic infections tend to afflict children with oral soothing habits. Methods: This is a case report will present the rare occurrence of a paronychia in a neonate caused by methicillin-resistant Staphylococcus aureus. Results: The management and treatment strategies for paronychia in this atypical neonatal patient consisted of incision and drainage and antibiotic therapy. Conclusion: Neonates with oral self-soothing behaviors may be more at risk for developing paronychia of mixed anaerobic and aerobic infections. Initial therapy with broad-spectrum antibiotics amoxicillin/clavulanate or clindamycin is suggested. Incision and drainage in the perinatal setting coupled with antibiotics is curative.

scholarly journals Treatment of Carbapenem-Resistant Enterobacteriaceae Infections in Children

2019 ◽  
Vol 9 (1) ◽  
pp. 56-66 ◽  
Author(s):  
Kathleen Chiotos ◽  
Molly Hayes ◽  
Jeffrey S Gerber ◽  
Pranita D Tamma
Keyword(s):  
Comparative Effectiveness ◽  
Treatment Strategies ◽  
Relative Lack ◽  
Carbapenem Resistant ◽  
The Us ◽  
New Antibiotics ◽  
Dosing Regimens ◽  
Enterobacteriaceae Infections ◽  
Effectiveness Data ◽  
Carbapenem Resistant Enterobacteriaceae

Abstract Infections due to carbapenem-resistant Enterobacteriaceae (CRE) are increasingly prevalent in children and are associated with poor clinical outcomes. Optimal treatment strategies for CRE infections continue to evolve. A lack of pediatric-specific comparative effectiveness data, uncertain pediatric dosing regimens for several agents, and a relative lack of new antibiotics with pediatric indications approved by the US Food and Drug Administration (FDA) collectively present unique challenges for children. In this review, we provide a framework for antibiotic treatment of CRE infections in children, highlighting relevant microbiologic considerations and summarizing available data related to the evaluation of FDA-approved antibiotics (as of September 2019) with CRE activity, including carbapenems, ceftazidime-avibactam, meropenem-vaborbactam, imipenem/cilastatin-relebactam, polymyxins, tigecycline, eravacycline, and plazomicin.

scholarly journals Comparative Effectiveness of Antibiotic Treatment Strategies for Pediatric Skin and Soft-Tissue Infections

PEDIATRICS ◽  
2011 ◽  
Author(s):  
D. J. Williams ◽  
W. O. Cooper ◽  
L. A. Kaltenbach ◽  
J. A. Dudley ◽  
D. L. Kirschke ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Antibiotic Treatment ◽  
Comparative Effectiveness ◽  
Treatment Strategies ◽  
Soft Tissue Infections
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