Background and Aims: Gabapentin and pregabalin, by
decreasing noxious stimulus induced excitatory
neurotransmitter release at central nervous system, may
attenuate central sensitization and eventually decrease
development of postoperative pain. We evaluated preemptive
analgesic efficacy of single dose of oral gabapentin 600 mg
and pregabalin 75mg for postoperative pain in patients
undergoing lower limb orthopedic surgery under spinal
anesthesia.
Material and methods: A prospective, randomized, double
blind study was conducted on 70 patients aged between 18 to
60 years with ASA grade 1 and 2 posted for lower limb surgeries
under spinal anaesthesia. Patients were allocated into Group
A and Group B receiving oral gabapentin(600mg) and oral
pregabalin (75mg) respectively 1.5 hours before surgery.
Primary objective was assessing duration and quality of
analgesia by Visual Analogue Scale (VAS) score at
2,4,6,8,10,12,16,20 and 24 hours.Secondary objective was to
assess total dose of rescue analgesic in first 24 hours, perioperative hemodynamic change and various side effects.
Statistical Analysis used: Categorical data was compared using
Chi- square test. Quantitative parametric data was analysed
using unpaired student t-test. P value < 0.05 was considered
statistically significant.
Results: Mean duration of analgesia in Group A (10.53 ± 2.686
hours) was longer than Group B (7.943±3.199hr) (P =
0.0006).Mean number of analgesic dosesrequired in first 24
hourswere less in Group A (1.429 ± 0.5021) ascompared to
Group B (1.771±0.6897) (P = 0.0202).All patients remained
hemodynamically stable with no significant side effects noted
in either group.
Conclusion: We conclude that preemptive analgesic efficacy
of oral gabapentin 600mg is better in comparison to oral
pregabalin 75 mg for patients posted for lower limb orthopedic
surgeries under spinal anesthesia.