Fractional exhaled nitric oxide, methacholine, or forced expiratory flow between 25% and 75%

2017 ◽  
Vol 118 (2) ◽  
pp. 235 ◽  
Author(s):  
Giorgio Ciprandi
Keyword(s):  
Nitric Oxide ◽  
Exhaled Nitric Oxide ◽  
Fractional Exhaled Nitric Oxide ◽  
Forced Expiratory Flow ◽  
Expiratory Flow

scholarly journals Fração Exalada de Óxido Nítrico no Controlo e Abordagem Terapêutica da Asma

2014 ◽  
Vol 27 (1) ◽  
pp. 59 ◽  
Author(s):  
Bruno Melo ◽  
Patrício Costa ◽  
Ariana Afonso ◽  
Vânia Machado ◽  
Carla Moreira ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Asthma Control ◽  
Peak Expiratory Flow ◽  
Chronic Respiratory Disease ◽  
Exhaled Nitric Oxide ◽  
Fractional Exhaled Nitric Oxide ◽  
Cross Sectional ◽  
Asthmatic Children ◽  
Bronchial Inflammation ◽  
Expiratory Flow

<strong>Introduction:</strong> Asthma is a chronic respiratory disease characterized by hyper-responsiveness and bronchial inflammation. The bronchial inflammation in these patients can be monitored by measuring the fractional exhaled nitric oxide. This study aims to determine fractional exhaled nitric oxide association with peak expiratory flow and with asthma control inferred by the Global Initiative for Asthma.<br /><strong>Material and Methods:</strong> Observational, analytical and cross-sectional study of children with asthma, 6-12 years-old, followed in the Outpatient Respiratory Pathology of Braga Hospital. Sociodemographic and clinical information were collected through a questionnaire. fractional exhaled nitric oxide and peak expiratory flow were determined by portable analyzer Niox Mino® and flow meter, respectively.<br /><strong>Results:</strong> The sample is constituted by 101 asthmatic children, 63 (62.4%) of males and 38 (37.6%) females. The mean age of participants in the sample is 9.18 (1.99) years. The logistic regression performed with the cutoff value obtained by ROC curve, revealed that fractional exhaled nitric oxide (bFENO classes = 0.85; χ2 Wald (1) = 8.71; OR = 2.33; p = 0.003) has a statistical significant effect on the probability of changing level of asthma control. The odds ratio of going from “controlled” to “partly controlled/uncontrolled” is 2.33 per each level of fractional exhaled nitric oxide.<br /><strong>Discussion and Conclusion: </strong>The probability of an asthmatic children change their level of asthma control, from ‘controlled’ to ‘partly controlled/uncontrolled’, taking into account a change in their fractional exhaled nitric oxide level, increases 133%.

scholarly journals Fractional exhaled nitric oxide could identify early spirometry change in clinically suspected asthma patients without airway obstruction

2021 ◽  
Vol 19 ◽  
pp. 205873922110041
Author(s):  
Qingbo Gao ◽  
Qiaozhen Wu ◽  
Fei Li ◽  
Cheng Chen
Keyword(s):  
Nitric Oxide ◽  
Airway Obstruction ◽  
Significant Proportion ◽  
Exhaled Nitric Oxide ◽  
Fractional Exhaled Nitric Oxide ◽  
Maximal Expiratory Flow ◽  
Increased Risk ◽  
Significant Difference ◽  
Expiratory Flow ◽  
Feno Level

Fractional exhaled nitric oxide (FeNO) has been proposed as a non-invasive biomarker for allergic inflammation seen in asthma. The aim of this study was to assess the ability of FeNO to discriminate spirometry and lung volume measurements between those with and without airway obstruction among subjects with clinically suspected asthma. A retrospective study was conducted. Diagnostic evaluations including spirometry and FeNO testing (NO electrochemical equipment: NIOX VERO; Aerocrine AB, Solna, Sweden) were performed in all subjects. Airway obstruction was defined according to the Standardization of Spirometry of the American Thoracic Society (ATS)/European Respiratory Society (ERS), and 2014 recommendations of the Chinese National Guidelines of Pulmonary Function Test. It was used the Student t test for analysis of continuous variables and the χ2 test for analysis of discrete variables including FeNO levels and lung function metrics. Of the 138 subjects with clinically suspected asthma, airway obstruction was found in 61. There was no significant difference in the mean FeNO levels among subjects with or without airway obstruction ( p = 0.241) among un-selected subjects. Likewise, there was no difference in the FeNO levels between aged (>50 years) and younger subjects (⩽50 years) ( p = 0.804). A significant proportion of subjects had a normal FeNO level (<25 part per billion, ppb) in spite of having airway obstruction (39/138), 25 had an elevated FeNO level (⩾25 ppb) in spite of having no airway obstruction (25/138). Additionally, the airway-obstructed subjects with increased FeNO level had comparable spirometry to those with normal FeNO level ( p > 0.05). However, among subjects without airway obstruction, the forced expiratory volume in 1 s (FEV1)/predicted (pred), maximal expiratory flow at 25% of forced vital capacity (FVC) (MEF25%)/pred, maximal expiratory flow at 50% of FVC (MEF50%)/pred and maximum mid-expiratory flow (MMEF)/pred were significantly lower in the FeNO ⩾ 25 ppb group compared to those in the FeNO < 25 ppb group. These analyses indicated that increased FeNO levels could help to determinate early spirometry change within clinically suspected asthma subjects without airway obstruction. It is highlighted the importance of FeNO as a phenotype associated with an increased risk of airway obstruction in some subjects in this study.

Associations between air pollutants and peak expiratory flow and fractional exhaled nitric oxide in students

2020 ◽  
Vol 24 (2) ◽  
pp. 189-195
Author(s):  
M. A. Adman ◽  
J. H. Hashim ◽  
M. R. A. Manaf ◽  
D. Norback
Keyword(s):  
Nitric Oxide ◽  
Air Pollution ◽  
Peak Expiratory Flow ◽  
Air Pollutants ◽  
Exhaled Nitric Oxide ◽  
Air Pollutant ◽  
Outdoor Air ◽  
Fractional Exhaled Nitric Oxide ◽  
Outdoor Air Pollution ◽  
Expiratory Flow

BACKGROUND: Studies on the effects of outdoor air pollution on the respiratory health of students in tropical countries such as Malaysia are limited.OBJECTIVE: To assess associations between outdoor air pollutants and peak expiratory flow (PEF) and fractional exhaled nitric oxide (FeNO).METHOD: PEF and FeNO levels of 487 students recruited in Melaka and Putrajaya, Malaysia, were measured in April and June 2014. Multiple linear regression with mutual adjustment was used to analyse the associations between exposure to air pollution and health.RESULTS: PEF was significantly associated with ozone for 1-day exposure (β = −13.3 l/min, 95% CI −22.7 to −3.8), carbon monoxide for 2-day exposure (β = −57.2 l/min, 95% CI −90.7 to −23.7) and particulate matter ≦10 μm in diameter for 3-day exposure (β = −6.0 l/min, 95% CI −9.2 to −2.8) and 7-day exposure (β = −8.6 l/min, 95% CI −13.0 to −4.1). Stratified analysis showed that associations between PEF and outdoor air pollutant exposures were similar in students with and without elevated FeNO levels.CONCLUSION: Outdoor air pollution in Malaysia may cause airway obstruction unrelated to eosinophilic airway inflammation among students as measured using FeNO.

scholarly journals Electronic Cigarettes: Impact on Lung Function and Fractional Exhaled Nitric Oxide Among Healthy Adults

2018 ◽  
Vol 13 (1) ◽  
pp. 155798831880607 ◽  
Author(s):  
Sultan Ayoub Meo ◽  
Muhammad Abdullah Ansary ◽  
Fahad Rayan Barayan ◽  
Abdulaziz Sulaiman Almusallam ◽  
Abdulrahman Muteb Almehaid ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Lung Function ◽  
Global Health ◽  
Electronic Cigarettes ◽  
Control Group ◽  
Healthy Male ◽  
Fractional Exhaled Nitric Oxide ◽  
Forced Expiratory Flow ◽  
Expiratory Flow ◽  
The Impact

Electronic cigarettes (e-cigarettes) are rapidly becoming an alternative form of nicotine consumption worldwide and a disruptive element in the global health diplomacy. This study aimed to investigate the impact of e-cigarettes on lung function and fractional exhaled nitric oxide (FeNO) among young healthy male adults. Sixty apparently healthy male volunteers were recruited and divided into two groups. Group 1 (e-cigarette-exposed group) consisted of 30 males who were daily e-cigarette users (age 27.07 ± 6.00 [mean ± SD] years). Group 2 (control group) consisted of 30 males who were not e-cigarette users (age 25.90 ± 7.72 [mean ± SD] years). Both groups were neither current nor former traditional tobacco users. Age, ethnicity, height, weight, and socioeconomic status were considered using a matched design to investigate the impact of e-cigarette use on lung function and FeNO. The lung function test parameters that were found to be significantly decreased in e-cigarette users compared to their control group were forced expiratory volume in the first second (FEV1), forced expiratory ratio (FEV1/FVC), forced expiratory flow—25% (FEF25%), forced expiratory flow—50% (FEF50%), forced expiratory flow—75% (FEF75%), forced expiratory flow—25%–75% (FEF25%–75%), and forced expiratory flow—75%–85% (FEF75%–85%). FeNO was also decreased in e-cigarette users, but it did not reach the level of significance. The use of e-cigarettes significantly impaired various lung function parameters and the pattern of impairment exhibited a peripheral obstructive airway involvement. These findings have a general message for the global health community on the potential harm of e-cigarettes on lung function.

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