Blindness, tetraspasticity, and other signs of irreversible brain damage in hereditary angioedema

2017 ◽  
Vol 118 (4) ◽  
pp. 520-521 ◽  
Author(s):  
Konrad Bork ◽  
Randolf Brehler ◽  
Günther Witzke ◽  
Stephan Boor ◽  
Wolf Heineke ◽  
...  
Keyword(s):  
Brain Damage ◽  
Hereditary Angioedema ◽  
Irreversible Brain Damage

Ischemic neuronal damage after acute subdural hematoma in the rat: effects of pretreatment with a glutamate antagonist

1991 ◽  
Vol 74 (6) ◽  
pp. 944-950 ◽  
Author(s):  
Min-Hsiung Chen ◽  
Ross Bullock ◽  
David I. Graham ◽  
Jimmy D. Miller ◽  
James McCulloch
Keyword(s):  
Brain Damage ◽  
Subdural Hematoma ◽  
Neuronal Damage ◽  
Nmda Receptor Antagonist ◽  
Acute Subdural Hematoma ◽  
Ischemic Brain Damage ◽  
Ischemic Brain ◽  
Content Type ◽  
Irreversible Brain Damage ◽  
Slow Injection

✓ The ability of a competitive N-methyl-D-aspartate (NMDA) receptor antagonist (D-CPP-ene) to reduce irreversible brain damage has been examined in a rodent model of acute subdural hematoma. Acute subdural hematoma was produced by the slow injection of 400 µl homologous blood into the subdural space overlying the parietal cortex in halothane-anesthetized rats. Brain damage was assessed histologically in sections at multiple coronal planes in animals sacrificed 4 hours after induction of the subdural hematoma. Pretreatment with D-CPP-ene (15 mg/kg) significantly reduced the volume of ischemic brain damage produced by the subdural hematoma from 62 ± 8 cu mm (mean ± standard error of the mean) in vehicle-treated control rats to 29 ± 7 cu mm in drug-treated animals. These data demonstrate the anti-ischemic efficacy of NMDA antagonists in an animal model of intracranial hemorrhage in which intracranial pressure is elevated, and suggest that excitotoxic mechanisms (which are susceptible to antagonism by D-CPP-ene) may play a role in the ischemic brain damage which is observed in patients who die after acute subdural hematoma.

scholarly journals Iodine deficiency conditions in the Tukayevsky District of Tatarstan

2001 ◽  
Vol 82 (5) ◽  
pp. 377-377
Author(s):  
Z. M. Zakirov ◽  
R. M. Kharisova
Keyword(s):  
Mental Retardation ◽  
Brain Damage ◽  
Congenital Hypothyroidism ◽  
Iodine Deficiency ◽  
Endemic Goiter ◽  
Entire Population ◽  
Irreversible Brain Damage ◽  
Intellectual Potential

Iodine is a micronutrient: the daily requirement is 100-200 mcg. The most obvious manifestation of iodine deficiency is endemic goiter. Iodine deficiency increases the frequency of congenital hypothyroidism and leads to irreversible brain damage in the fetus and newborn. In addition to pronounced forms of mental retardation, iodine deficiency causes a decrease in the intellectual potential of the entire population living in an area of iodine deficiency.

Familial Hemiplegic Migraine with Irreversible Brain Damage.

1998 ◽  
Vol 37 (2) ◽  
pp. 166-168 ◽  
Author(s):  
Ryuichiro HAYASHI ◽  
Hiroshi TACHIKAWA ◽  
Ryo WATANABE ◽  
Masao HONDA ◽  
Yasushi KATSUMATA
Keyword(s):  
Brain Damage ◽  
Familial Hemiplegic Migraine ◽  
Hemiplegic Migraine ◽  
Irreversible Brain Damage

Children With Irreversible Brain Damage Associated With Hypothyroidism and Multiple Intracranial Calcifications

2002 ◽  
Vol 17 (4) ◽  
pp. 309-313 ◽  
Author(s):  
Junko Arii ◽  
Yuzo Tanabe ◽  
Michiko Makino ◽  
Hirokazu Sato ◽  
Yoichi Kohno
Keyword(s):  
Brain Damage ◽  
Intracranial Calcifications ◽  
Irreversible Brain Damage

Early Prediction of Irreversible Brain Damage after Ischemic Stroke at CT

Radiology ◽  
2001 ◽  
Vol 219 (1) ◽  
pp. 95-100 ◽  
Author(s):  
Rüdiger von Kummer ◽  
Holger Bourquain ◽  
Stefano Bastianello ◽  
Luigi Bozzao ◽  
Claude Manelfe ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Brain Damage ◽  
Early Prediction ◽  
Irreversible Brain Damage

Letters to the Editor

PEDIATRICS ◽  
1964 ◽  
Vol 34 (3) ◽  
pp. 435-435
Author(s):  
WILLIAM J. WATERS
Keyword(s):  
Brain Damage ◽  
Letters To The Editor ◽  
Bilirubin Encephalopathy ◽  
Early Signs ◽  
Irreversible Brain Damage ◽  
The Future ◽  
Close Observation ◽  
Neurological Disturbance

Dr. Zoger's point is well taken. We hope to be able to give a satisfactory follow-up report in the future. I believe as Dr. Byers indicated in his article that close observation of the jaundiced infant will help to detect early signs of neurological disturbance. Increasing lethargy and decreasing response of Moro, suck, and grasp should alert the clinician to the possibility of irreversible brain damage (bilirubin encephalopathy).

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