Induction of heat-shock protein 70 by prostaglandin A1 inhibits HIV-1 Vif-mediated degradation of APOBEC3G

2013 ◽  
Vol 99 (3) ◽  
pp. 307-311 ◽  
Author(s):  
Ryuichi Sugiyama ◽  
Makoto Abe ◽  
Hironori Nishitsuji ◽  
Yuko Murakami ◽  
Hiroaki Takeuchi ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Prostaglandin A1 ◽  
Hiv 1

Heat-Shock Protein 70 Can Replace Viral Protein R of HIV-1 during Nuclear Import of the Viral Preintegration Complex

2000 ◽  
Vol 259 (2) ◽  
pp. 398-403 ◽  
Author(s):  
Isabelle Agostini ◽  
Serguei Popov ◽  
Jianhua Li ◽  
Larisa Dubrovsky ◽  
Tang Hao ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Nuclear Import ◽  
Viral Protein ◽  
Heat Shock Protein 70 ◽  
Preintegration Complex ◽  
Viral Protein R ◽  
Hiv 1

scholarly journals Heat Shock Protein 70 Inhibits HIV-1 Vif-mediated Ubiquitination and Degradation of APOBEC3G

2011 ◽  
Vol 286 (12) ◽  
pp. 10051-10057 ◽  
Author(s):  
Ryuichi Sugiyama ◽  
Hironori Nishitsuji ◽  
Ayako Furukawa ◽  
Masato Katahira ◽  
Yuichiro Habu ◽  
...  
Keyword(s):  
Heat Shock ◽  
Antiviral Activity ◽  
Heat Shock Protein ◽  
Heat Shock Protein 70 ◽  
Cytidine Deaminase ◽  
Host Protein ◽  
Hsp70 Expression ◽  
Dependent Manner ◽  
Reverse Transcription Step ◽  
Hiv 1

The cytidine deaminase APOBEC3G, which is incorporated into nascent virus particles, possesses potent antiviral activity and restricts Vif-deficient HIV-1 replication at the reverse transcription step through deamination-dependent and -independent effects. HIV-1 Vif counteracts the antiviral activity of APOBEC3G by inducing APOBEC3G polyubiquitination and its subsequent proteasomal degradation. In this study, we show that overexpression of heat shock protein 70 (HSP70) blocked the degradation of APOBEC3G in the ubiquitin-proteasome pathway by HIV-1 Vif, rendering the viral particles non-infectious. In addition, siRNA targeted knock-down of HSP70 expression enhanced the Vif-mediated degradation of APOBEC3G. A co-immunoprecipitation study revealed that overexpression of HSP70 inhibited APOBEC3G binding to HIV-1 Vif. Thus, we provide evidence for a host protein-mediated suppression of HIV-1 replication in an APOBEC3G-dependent manner.

Ammonia aggravates emotional stress-induced gastric mucosal oxidative injury through the cancellation of heat shock protein 70 (HSP70)

2001 ◽  
Vol 120 (5) ◽  
pp. A152-A152
Author(s):  
H SUZUKI ◽  
S NAGAHASHI ◽  
M MIYAZAWA ◽  
M MORI ◽  
H NAGATA ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Emotional Stress ◽  
Heat Shock Protein 70 ◽  
Oxidative Injury
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