Recent developments in the medicinal chemistry of single boron atom-containing compounds

: The synthesis of ester containing heterocyclic compounds via multicomponent reaction is one of the most preferable process in the synthetic organic chemistry and medicinal chemistry. Compounds containing ester linkage have a wide range of biological application in the pharmaceutical field. Therefore, many method have been developed for the synthesis of these type of derivatives. However, some of them are carried out in the presence of toxic solvents and catalysts, with lower yields, longer reaction times, low selectivities and by-products. Thus, the development of new synthetic methods for the ester synthesis is required in the medicinal chemistry. As we know, multicomponent reactions (MCRs) are a powerful tool towards the one-pot ester synthesis, so in this article we have reviewed the recent developments in ester synthesis. This work covers selected explanation of methods via multicomponent reactions to explore the methodological development in ester synthesis.

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Recent Developments in the Medicinal Chemistry for New Small-Molecule Therapeutics to Treat HIV-AIDS

Current Topics in Medicinal Chemistry ◽

10.2174/156802661918191009110427 ◽

2019 ◽

Vol 19 (18) ◽

pp. 1569-1570 ◽

Cited By ~ 1

Author(s):

Mrinmoy Saha ◽

Shreya Bhattacharya

Keyword(s):

Small Molecule ◽

Medicinal Chemistry ◽

Recent Developments ◽

Small Molecule Therapeutics ◽

Hiv Aids

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Recent Developments in the Use of Flow Hydrogenation in the Field of Medicinal Chemistry

New Advances in Hydrogenation Processes - Fundamentals and Applications ◽

10.5772/65518 ◽

2017 ◽

Author(s):

Cecilia C. Russell ◽

Jennifer R. Baker ◽

Peter J. Cossar ◽

Adam McCluskey

Keyword(s):

Medicinal Chemistry ◽

Recent Developments

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Synthesis of Imidazole-Based Medicinal Molecules Utilizing the van Leusen Imidazole Synthesis

Pharmaceuticals ◽

10.3390/ph13030037 ◽

2020 ◽

Vol 13 (3) ◽

pp. 37 ◽

Cited By ~ 5

Author(s):

Xunan Zheng ◽

Zhengning Ma ◽

Dawei Zhang

Keyword(s):

Drug Discovery ◽

Chemical Synthesis ◽

Small Molecules ◽

Medicinal Chemistry ◽

Biological Activities ◽

Structural Features ◽

Pharmaceutical Companies ◽

Recent Developments ◽

Van Leusen Reaction

Imidazole and its derivatives are one of the most vital and universal heterocycles in medicinal chemistry. Owing to their special structural features, these compounds exhibit a widespread spectrum of significant pharmacological or biological activities, and are widely researched and applied by pharmaceutical companies for drug discovery. The van Leusen reaction based on tosylmethylisocyanides (TosMICs) is one of the most appropriate strategies to synthetize imidazole-based medicinal molecules, which has been increasingly developed on account of its advantages. In this review, we summarize the recent developments of the chemical synthesis and bioactivity of imidazole-containing medicinal small molecules, utilizing the van Leusen imidazole synthesis from 1977.

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A New Class of Synthetic Flavonolignan-Like Dimers: Still Few Molecules, but with Attractive Properties

Molecules ◽

10.3390/molecules24010108 ◽

2018 ◽

Vol 24 (1) ◽

pp. 108 ◽

Cited By ~ 2

Author(s):

Valeria Romanucci ◽

Giovanni Di Fabio ◽

Armando Zarrelli

Keyword(s):

Antioxidant Activity ◽

Medicinal Chemistry ◽

Biological Response ◽

Milk Thistle ◽

Silybum Marianum ◽

New Class ◽

Therapeutic Value ◽

Recent Developments

In recent years, there has been increasing interest in dimeric molecules due to reports of their promising therapeutic value in the treatment of numerous diseases (such as cancer, HIV, Alzheimer’s and, malaria). Many reports in the literature have highlighted the ability of these molecules to interact not only with specific biologic receptors but also to induce a biological response that more than doubles the results of the corresponding monomeric counterpart. In this regard, flavonolignan dimers or simply bi-flavonolignans are an emerging class of dimeric compounds that unlike bi-flavonoids, which are very widespread in nature, consist of synthetic dimers of some flavonolignans isolated from the milk thistle Silybum marianum [L. Gaertn. (Asteraceae)]. This mini-review will discuss recent developments in the synthesis, characterization and antioxidant activity of new families of flavonolignan dimers, in light of emerging medicinal chemistry strategies.

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