scholarly journals Inhibition of the CDK9‒cyclin T1 protein‒protein interaction as a new approach against triple-negative breast cancer

2021 ◽  
Author(s):  
Sha-Sha Cheng ◽  
Yuan-Qing Qu ◽  
Jia Wu ◽  
Guan-Jun Yang ◽  
Hao Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Protein Interaction ◽  
Triple Negative ◽  
New Approach ◽  
Protein Protein Interaction ◽  
Cyclin T1

Evaluation of Local Injection of Bevacizumab against Triple-Negative Breast Cancer Xenograft Tumors

2019 ◽  
Vol 25 (8) ◽  
pp. 862-870
Author(s):  
Xin Jiang ◽  
Qiao-Li Zhang ◽  
Tie-Gang Liu ◽  
Wei-Peng Zhao ◽  
Ming Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Matrix Metalloproteinase ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Local Delivery ◽  
Local Injection ◽  
Vegf Receptor ◽  
Protein Protein Interaction ◽  
Local Injections

Background and objective:Bevacizumab (BVZ) is a recombinant humanized antibody that inhibits the vascular endothelial growth factor A (VEGFA) and is used for the treatment of various types of cancer. BVZ is primarily given by the intravenous drip (I.V.), which often leads to low efficacy and various side effects. Therefore, the present study was to evaluate the effect of local delivery of BVZ against triple-negative breast cancer (TNBC) xenograft tumors.Methods:Mice 4T1 TNBC cells were engrafted in female BALB/c mice. After the tumors reached about 5 mm (diameter), animals were treated with BVZ through the local injection from four directions around the tumors. The tumor growth, survival and potential mechanisms of action were evaluated.Results:The growth and microvessel density of engrafted tumors were dramatically reduced with the tumor inhibition rate of 32.8 ± 3%. No obvious side effects were observed. The expression of VEGFA, VEGF receptor (VEGFR), matrix metalloproteinase (MMP)-2, MMP-9, Delta-like ligand 4 (DLL4) and Integrin-5 was significantly reduced in TNBC tumor tissues. In contrast, tissue inhibitor of matrix metalloproteinase (TIMP)-2 was significantly upregulated in xenograft tumors. Additionally, local delivery of BVZ led to the reduction of VEGFA and tumor necrosis factor (TNF)-alpha in the serum. Protein-protein interaction (PPI) analysis revealed that the proteins altered by the local delivery of BVZ were associated with angiogenesis and regulation of cell migration.Conclusion:This study provided evidence associated with local delivery of BVZ against TNBC tumors supporting the use of BVZ local injections to overcome some of the disadvantages associated with I.V. therapy with BVZ.

ENCAPSULATION OF ANTITUMOR COPPER COMPLEX INTO LIPOSOMES

2020 ◽  
pp. 190-191
Author(s):  
K. Vlasova ◽  
O. Krasnovskaya ◽  
N. Klyachko
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Triple Negative Breast Cancer ◽  
Copper Complex ◽  
Triple Negative ◽  
Complex Loading ◽  
Breast Cancer Treatment ◽  
New Approach ◽  
Copper Coordination ◽  
Liposomal Suspension

To encapsulate a new copper coordination compound drug for triple-negative breast cancer treatment we have developed a new approach. The obtained liposomal suspension is stable up to 2 weeks; successful complex loading is confirmed spectrophotometrically and can be quantified by HPLC.

scholarly journals SR-B1-targeted nanodelivery of anti-cancer agents: a promising new approach to treat triple-negative breast cancer

2017 ◽  
Vol Volume 9 ◽  
pp. 383-392 ◽  
Author(s):  
Rebecca Johnson ◽  
Nirupama Sabnis ◽  
Xiangle Sun ◽  
Ruhani Ahluwalia ◽  
Andras Lacko
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
New Approach ◽  
Anti Cancer

Targeting mutant p53 with COTI-2: A new approach for the treatment of patients with triple-negative breast cancer?

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e13121-e13121 ◽  
Author(s):  
Naoise C Synnott ◽  
David J O'Connell ◽  
John Crown ◽  
Michael J. Duffy
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Mutant P53 ◽  
New Approach

Identification of new therapeutic leads for triple negative breast cancer subtypes

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
AJ Robles ◽  
L Du ◽  
S Cai ◽  
RH Cichewicz ◽  
SL Mooberry
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Breast Cancer Subtypes ◽  
Cancer Subtypes ◽  
Therapeutic Leads
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