Thin films of polymer mimics of cross-linking mussel adhesive proteins deposited by matrix assisted pulsed laser evaporation

The unusual amino acid 3,4-dihydroxyphenylalanine with a catechol side chain is believed to impart both adhesive and cohesive characteristics of mussel adhesive proteins. Inspired by the pH-tunable coordination between catechol moiety and Fe3+, responsible for the high extensibility and self-healing properties of the cuticle of mussel byssal threads, we report the synthesis of a dopamine modified Pluronic F68 block copolymer (PluF68-Dopa) with high coupling efficiency and utilization of catechol-Fe3+interactions to yield cross-linking hydrogels with enhanced mechanical strength and self-healing properties. Ultraviolet-visible spectroscopy was used to identify PluF68-Dopa-Fe3+complex species via pH control in dilution solution. At lower pH, concentrated PluF68-Dopa-Fe3+mixture remained a fluid, whereas at higher pH an elastomeric gel immediately formed. PluF68-Dopa-Fe3+cross-linked hydrogels are not only pH-responsive but also possess self-healing properties due to the reversible bond interactions between catechol moiety and Fe3+. These new biomimetic materials are expected to have potential biomedical and engineering applications.

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Cross-Linking and Multilayer Adsorption of Mussel Adhesive Proteins

Langmuir ◽

10.1021/la025626c ◽

2002 ◽

Vol 18 (12) ◽

pp. 4903-4907 ◽

Cited By ~ 29

Author(s):

Sander Haemers ◽

Mieke C. van der Leeden ◽

Ger J. M. Koper ◽

Gert Frens

Keyword(s):

Cross Linking ◽

Multilayer Adsorption ◽

Mussel Adhesive Proteins ◽

Mussel Adhesive ◽

Adhesive Proteins

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Density Functional Theory Study on the Cross-Linking of Mussel Adhesive Proteins

The Journal of Physical Chemistry B ◽

10.1021/acs.jpcb.5b01152 ◽

2015 ◽

Vol 119 (17) ◽

pp. 5496-5504 ◽

Cited By ~ 14

Author(s):

Mohammad A. Matin ◽

Ramesh Kumar Chitumalla ◽

Manho Lim ◽

Xingfa Gao ◽

Joonkyung Jang

Keyword(s):

Density Functional Theory ◽

Density Functional ◽

Cross Linking ◽

Density Functional Theory Study ◽

Functional Theory ◽

Mussel Adhesive Proteins ◽

The Cross ◽

Mussel Adhesive ◽

Adhesive Proteins

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Effect of Oxidation Rate on Cross-Linking of Mussel Adhesive Proteins

Biomacromolecules ◽

10.1021/bm025707n ◽

2003 ◽

Vol 4 (3) ◽

pp. 632-640 ◽

Cited By ~ 68

Author(s):

Sander Haemers ◽

Ger J. M. Koper ◽

Gert Frens

Keyword(s):

Oxidation Rate ◽

Cross Linking ◽

Mussel Adhesive Proteins ◽

Mussel Adhesive ◽

Adhesive Proteins

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Controlling the Distribution of CdSe Colloidal Quantum Dots in Conducting Polymer Nanocomposite Thin Films Using Matrix-Assisted Pulsed Laser Evaporation

10.1557/proc-1121-n18-05 ◽

2008 ◽

Author(s):

Adrienne D. Stiff-Roberts ◽

Ryan Pate ◽

Kevin R. Lantz

Keyword(s):

Thin Films ◽

Quantum Dots ◽

Conducting Polymer ◽

Pulsed Laser ◽

Polymer Nanocomposite ◽

Colloidal Quantum Dots ◽

Laser Evaporation ◽

Nanocomposite Thin Films ◽

Conducting Polymer Nanocomposite

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Engineering of Biofilms with a Glycosylation Circuit for Biomaterial Applications

Biomaterials Science ◽

10.1039/d0bm02192j ◽

2021 ◽

Author(s):

Ebru Sahin Kehribar ◽

Musa E İsilak ◽

Eray U. Bozkurt ◽

Jozef Adamcik ◽

Raffaele Mezzenga ◽

...

Keyword(s):

Spider Silk ◽

Post Translational Modification ◽

Adhesive Protein ◽

Mussel Adhesive Proteins ◽

Wide Range ◽

Mussel Adhesive ◽

Adhesive Proteins ◽

Glycosylated Proteins

Glycosylation is a crucial post-translational modification for a wide range of functionalities. Adhesive protein-based biomaterials in nature rely on heavily glycosylated proteins such as spider silk and mussel adhesive proteins....

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