Controllable biodegradation and drug release behavior of chitosan-graft-poly(D, L-lactic acid) synthesized by an efficient method

2020 ◽  
pp. 109458
Author(s):  
Qianyu Sun ◽  
Jie Sheng ◽  
Rendang Yang
Keyword(s):  
Lactic Acid ◽  
Drug Release ◽  
Efficient Method ◽  
Release Behavior ◽  
Drug Release Behavior

A New Approach for Polymer-Free Coating with Paclitaxel Microparticles on Fully-Bioabsorbable Poly(l-Lactic Acid) Stent and Studies of Drug Release Behavior

2015 ◽  
Vol 5 (2) ◽  
Author(s):  
Hirokazu Yamada ◽  
Mitsuhiko Kinoshita ◽  
Shinichi Yagi ◽  
Chisa Matsubara ◽  
Keiji Igaki ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Crystal Growth ◽  
Drug Release ◽  
Aqueous Solubility ◽  
Release Behavior ◽  
Drug Release Behavior ◽  
Initial Release ◽  
Antiproliferative Agent ◽  
Plla Stent ◽  
Growth Formation

A first clinically-used, fully-bioabsorbable poly(L-lactic acid) (PLLA) stent was coated with microcrystals of paclitaxel (PTX), antiproliferative agent through seeding and/or crystal growing technique to investigate the drug properties on the stent surface and drug release behavior from the stent. PTX particles subject to only seeding process was peeled off after stent compression, while less PTX was coated on the stent subject to only crystal growth without seeding. PLLA stent with both processes could stably maintain an increased amount of PTX on its surface. The maximum amount of initial release (10 μg/cm2) was found in the sample only with seeding, which decreased to 3 μg/cm2 or below after one week. Also in the PLLA stent only with crystal growth, release amount decreased after one week. In the PLLA stent with seeding and crystal growth, formation of needle-like PTX crystals on the surface resulted in decreased initial release and lower solubility after hydration in phosphate buffered solution compared to other types of stent with different procedures. It is suggested that both seeding and crystal growth are required for stable application of PTX on fully-bioabsorbable PLLA stent and needle-like crystals containing water have lower aqueous solubility resulting in decreased PTX release.

Preparation and Drug Release Behavior of Nifedipine-Loaded Poly(lactic acid)/Polyethylene Glycol Microcapsules

2021 ◽  
Vol 21 (7) ◽  
pp. 3735-3741
Author(s):  
Heeseok Jeong ◽  
Hyunju Lim ◽  
Deuk Yong Lee ◽  
Yo-Seung Song ◽  
Bae-Yeon Kim
Keyword(s):  
Lactic Acid ◽  
Polyethylene Glycol ◽  
Drug Release ◽  
Release Rate ◽  
Drug Carriers ◽  
Poly Lactic Acid ◽  
Release Behavior ◽  
Drug Release Rate ◽  
Water Emulsion ◽  
Drug Release Behavior

Nifedipine (NF)-loaded poly(lactic acid) (PLA) and PLA/polyethylene glycol (PLA/PEG) microcapsules are synthesized using a high-speed agitator and a syringe pump with an oil-in-water emulsion-solvent evaporation technique to evaluate the effect of PLA/PEG ratio on morphology and drug release behavior of the capsules. Fourier transform infrared spectroscopy (FT-IR), differential scanning calorimeter (DSC), and X-ray diffraction (XRD) results indicate that PEG reacts successfully with PLA due to the ether bond between PEG and PLA. The drug release rate of PLA and PLA/PEG capsules increases dramatically from 0 to 5 min and then reaches a plateau within 15 to 20 min. Due to the high specific surface area, the amount of NF released is raised by reducing the PLA concentration from 5 wt% to 2 wt%. Unlike PLA capsules, the drug release rate of PLA/PEG capsules increases due to the size effect by varying the PLA/PEG ratio from 10/0 to 6/4. Larger PLA/PEG capsules are attributed to higher amounts of encapsulated NF. The capsules show no evidence of cytotoxicity, suggesting that the PLA and PLA/PEG drug carriers are clinically safe.

scholarly journals Nanoformulation and Evaluation of Oral Berberine-Loaded Liposomes

Molecules ◽  
2021 ◽  
Vol 26 (9) ◽  
pp. 2591
Author(s):  
Thuan Thi Duong ◽  
Antti Isomäki ◽  
Urve Paaver ◽  
Ivo Laidmäe ◽  
Arvo Tõnisoo ◽  
...  
Keyword(s):  
Thin Film ◽  
Drug Release ◽  
Size Distribution ◽  
Water Soluble ◽  
Release Behavior ◽  
Uniform Size ◽  
Ethanol Injection ◽  
Drug Release Behavior ◽  
Poorly Water Soluble

Berberine (BBR) is a poorly water-soluble quaternary isoquinoline alkaloid of plant origin with potential uses in the drug therapy of hypercholesterolemia. To tackle the limitations associated with the oral therapeutic use of BBR (such as a first-pass metabolism and poor absorption), BBR-loaded liposomes were fabricated by ethanol-injection and thin-film hydration methods. The size and size distribution, polydispersity index (PDI), solid-state properties, entrapment efficiency (EE) and in vitro drug release of liposomes were investigated. The BBR-loaded liposomes prepared by ethanol-injection and thin-film hydration methods presented an average liposome size ranging from 50 nm to 244 nm and from 111 nm to 449 nm, respectively. The PDI values for the liposomes were less than 0.3, suggesting a narrow size distribution. The EE of liposomes ranged from 56% to 92%. Poorly water-soluble BBR was found to accumulate in the bi-layered phospholipid membrane of the liposomes prepared by the thin-film hydration method. The BBR-loaded liposomes generated by both nanofabrication methods presented extended drug release behavior in vitro. In conclusion, both ethanol-injection and thin-film hydration nanofabrication methods are feasible for generating BBR-loaded oral liposomes with a uniform size, high EE and modified drug release behavior in vitro.

In vivo drug release behavior and osseointegration of a doxorubicin-loaded tissue-engineered scaffold

RSC Advances ◽  
2016 ◽  
Vol 6 (80) ◽  
pp. 76237-76245 ◽  
Author(s):  
M. Sun ◽  
M. Chen ◽  
M. Wang ◽  
J. Hansen ◽  
A. Baatrup ◽  
...  
Keyword(s):  
Clinical Study ◽  
Drug Release ◽  
Bone Formation ◽  
Chemotherapeutic Agent ◽  
Dual Function ◽  
Release Behavior ◽  
Drug Release Behavior

This pre-clinical study presented a dual function of a doxorubicin-loaded scaffold for both chemotherapeutic agent delivery and bone formation.

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