The mechanically activated p38/MMP-2 signaling pathway promotes bone marrow mesenchymal stem cell migration in rats

2017 ◽  
Vol 76 ◽  
pp. 55-60 ◽  
Author(s):  
Zihui Yang ◽  
Baolei Wu ◽  
Sen Jia ◽  
Yinghua Zhao ◽  
Rui Hou ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cell Migration ◽  
Mesenchymal Stem Cell ◽  
Signaling Pathway ◽  
Stem Cell Migration

17β-estradiol promotes bone marrow mesenchymal stem cell migration mediated by chemokine upregulation

2020 ◽  
Vol 530 (2) ◽  
pp. 381-388 ◽  
Author(s):  
Wenbi Zhang ◽  
Xiong Li ◽  
He Li ◽  
Xiang Lu ◽  
Junling Chen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cell Migration ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Migration ◽  
17Β Estradiol

TNF-α Increases Bone Marrow Mesenchymal Stem Cell Migration to Ischemic Tissues

2011 ◽  
Vol 62 (3) ◽  
pp. 409-414 ◽  
Author(s):  
Qiong Xiao ◽  
Shi-kun Wang ◽  
Hua Tian ◽  
Li Xin ◽  
Zhi-geng Zou ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cell Migration ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Migration ◽  
Tnf Α

scholarly journals IL-1β-Induced Matrix Metalloprotease-1 Promotes Mesenchymal Stem Cell Migration via PAR1 and G-Protein-Coupled Signaling Pathway

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Ming-Siou Chen ◽  
Cheng-Yu Lin ◽  
Yun-Hsuan Chiu ◽  
Chie-Pein Chen ◽  
Pei-Jiun Tsai ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Migration ◽  
Mesenchymal Stem Cell ◽  
Signaling Pathway ◽  
G Protein ◽  
Interleukin 1 ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Stem Cell Migration ◽  
G Protein Coupled

Mesenchymal stem cells (MSCs) are known for homing to sites of injury in response to signals of cellular damage. However, the mechanisms of how cytokines recruit stem cells to target tissue are still unclear. In this study, we found that the proinflammation cytokine interleukin-1β (IL-1β) promotes mesenchymal stem cell migration. The cDNA microarray data show that IL-1β induces matrix metalloproteinase-1 (MMP-1) expression. We then used quantitative real-time PCR and MMP-1 ELISA to verify the results. MMP-1 siRNA transfected MSCs, and MSC pretreatment with IL-1β inhibitor interleukin-1 receptor antagonist (IL-1RA), MMP tissue inhibitor of metalloproteinase 1 (TIMP1), tissue inhibitor of metalloproteinase 2 (TIMP2), MMP-1 inhibitor GM6001, and protease-activated receptor 1 (PAR1) inhibitor SCH79797 confirms that PAR1 protein signaling pathway leads to IL-1β-induced cell migration. In conclusion, IL-1β promotes the secretion of MMP-1, which then activates the PAR1 and G-protein-coupled signal pathways to promote mesenchymal stem cell migration.

scholarly journals Effect of aged bone marrow microenvironment on mesenchymal stem cell migration

AGE ◽  
2015 ◽  
Vol 37 (2) ◽  
Author(s):  
Yan-Mei Yang ◽  
Ping Li ◽  
Dian-Chao Cui ◽  
Rui-Jie Dang ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cell Migration ◽  
Mesenchymal Stem Cell ◽  
Bone Marrow Microenvironment ◽  
Stem Cell Migration

scholarly journals Hypoxia and low-dose inflammatory stimulus synergistically enhance bone marrow mesenchymal stem cell migration

2016 ◽  
Vol 50 (1) ◽  
pp. e12309 ◽  
Author(s):  
Yang Yu ◽  
Yuan Yin ◽  
Rui-Xin Wu ◽  
Xiao-Tao He ◽  
Xi-Yu Zhang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cell Migration ◽  
Mesenchymal Stem Cell ◽  
Low Dose ◽  
Inflammatory Stimulus ◽  
Stem Cell Migration

scholarly journals e0206 Bone marrow mesenchymal stem cell migration depends in part on Kv21 channel activity

Heart ◽  
2010 ◽  
Vol 96 (Suppl 3) ◽  
pp. A66-A66
Author(s):  
H. Xinyang ◽  
Y. Shanping ◽  
W. Jian-an ◽  
W. Ling
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cell Migration ◽  
Mesenchymal Stem Cell ◽  
Channel Activity ◽  
Stem Cell Migration
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