Editorial Commentary: Long-Term Outcomes of Fresh-Frozen Meniscal Allografts—Shrinkage Progresses, but Is It Clinically Significant?

2019 ◽  
Vol 35 (10) ◽  
pp. 2896-2897
Author(s):  
Brian J. Cole ◽  
Eric D. Haunschild ◽  
Jorge Chahla
2009 ◽  
Vol 29 (2_suppl) ◽  
pp. 111-114 ◽  
Author(s):  
Rajnish Mehrotra

In many parts of the world, a progressively larger proportion of chronic peritoneal dialysis (PD) patients are being treated with automated PD (APD). Increasingly, the decision to use APD is being dictated by patient and physician preference rather than being based on medical considerations. It is important to determine if the PD modality has any effect on long-term patient outcomes. Studies examining the effects of APD on residual renal function have been inconsistent, and the effect of cycler use on native renal clearances, if any, is small and probably not clinically significant. The preponderance of the evidence suggests that peritonitis rates are somewhat lower in APD patients than in patients treated with continuous ambulatory PD (CAPD). Two of three recent studies indicated that the risk for transfer to maintenance hemodialysis may be lower in APD patients, particularly in the early period after starting chronic PD. However, the risk for death in patients treated with CAPD and APD appears to be similar in most of the studies that have looked at that question. In summary, the long-term outcomes of CAPD and APD appear to be similar, and patient and physician preference are likely to increase the utilization of APD in many parts of the world.


2021 ◽  
Vol 17 (9) ◽  
pp. 736-743
Author(s):  
Leor Perl ◽  
Amir Cohen ◽  
Alexander Dadashev ◽  
Yaron Shapira ◽  
Hana Vaknin-Assa ◽  
...  

2020 ◽  
pp. 229-232
Author(s):  
Danielle S. Shpiner ◽  
Sagari Bette ◽  
Corneliu C. Luca

“Outflow” tremors, sometimes referred to in the literature by a variety of terms (outflow, rubral, midbrain, Holmes), are frequently associated with significant disability and are notoriously unresponsive or only partially responsive to medical treatment. Deep brain stimulation (DBS) has been successfully used in patients with outflow tremors; however, long-term outcomes are not well-documented because large case series are hard to assemble. This chapter describes a patient with disabling outflow tremors secondary to multiple sclerosis, treated with unilateral thalamic DBS, who achieved excellent tremor control with initial programming but shortly afterward developed rebound tremor. Intensive programming involved alternating the site of stimulation by using different combinations of contacts; this was a successful strategy for maintaining a clinically significant reduction in tremor. Disease progression, worsening of tremor, habituation, and loss of efficacy are known problems with some tremors, and their management can be challenging. The pathophysiology of worsening tremor after DBS is discussed in the chapter, as are potential programming strategies to manage this problem.


2020 ◽  
Vol 9 (6) ◽  
pp. 2003
Author(s):  
Ismene Bilbao Garay ◽  
Adrian F. Daly ◽  
Nerea Egaña Zunzunegi ◽  
Albert Beckers

Clinically-relevant pituitary adenomas occur in about 1:1000 of the general population, but only about 5% occur in a known genetic or familial setting. Familial isolated pituitary adenomas (FIPA) are one of the most important inherited settings for pituitary adenomas and the most frequent genetic cause is a germline mutation in the aryl hydrocarbon receptor-interacting protein (AIP) gene. AIP mutations lead to young-onset macroadenomas that are difficult to treat. Most are growth hormone secreting tumors, but all other secretory types can exist and the clinical profile of affected patients is variable. We present an overview of the current understanding of AIP mutation-related pituitary disease and illustrate various key clinical factors using examples from one of the largest AIP mutation-positive FIPA families identified to date, in which six mutation-affected members with pituitary disease have been diagnosed. We highlight various clinically significant features of FIPA and AIP mutations, including issues related to patients with acromegaly, prolactinoma, apoplexy and non-functioning pituitary adenomas. The challenges faced by these AIP mutation-positive patients due to their disease and the long-term outcomes in older patients are discussed. Similarly, the pitfalls encountered due to incomplete penetrance of pituitary adenomas in AIP-mutated kindreds are discussed.


2006 ◽  
Vol 41 (2) ◽  
pp. 335-341 ◽  
Author(s):  
Priscilla P.L. Chiu ◽  
Maria Rusan ◽  
William G. Williams ◽  
Christopher A. Caldarone ◽  
Peter C.W. Kim

2020 ◽  
Vol 5;23 (9;5) ◽  
pp. E441-E449 ◽  
Author(s):  
G Niraj

Background: Abdominal myofascial pain syndrome is an important cause of refractory chronic abdominal pain. It causes severe functional impairment resulting in significant patient distress and substantial health care costs, and it can be a challenge to treat. Opioid consumption is a recognized challenge in this cohort. Design: We conducted a prospective longitudinal audit over a 6-year period. Setting: The study was conducted at a tertiary pain medicine clinic in a university teaching hospital. Methods: Over a 6-year period, 234 patients diagnosed with chronic abdominal pain secondary to abdominal myofascial pain syndrome were included in a structured management pathway. Long-term outcomes were prospectively audited at a tertiary-care university hospital. Patients who completed a minimum of 12 months in the pathway were included. The main outcome was reduction in opioid consumption. Treatment outcomes included treatment failure, number of patients with clinically significant pain relief, durable pain relief, and long-term pain relief. Other outcomes included patient satisfaction and success in maintaining gainful employment. Results: Two hundred seven patients completed a minimum of 12 months of follow-up. Seventyeight percent (162 of 207) were on opioids at presentation. There was significant reduction in opioid consumption at ≥ 12 months’ follow-up. Among patients who underwent interventional management, clinically significant relief was reported in 31 patients (31 of 180, 17%), durable relief in 71 patients (71 of 180, 40%) and long-term relief lasting 12 months in 23 patients (23 of 180, 13%). Twenty-six patients (26 of 180, 15%) reported cure from symptoms. The treatment failure rate was 15%. Limitations: This was an open-label study that took place at a single center. Conclusion: The authors present the first prospective practice-based evidence report on the long-term outcomes in patients diagnosed with abdominal myofascial pain syndrome. There was significant reduction in opioid consumption at 12 months and over two-thirds of patients reported significant durable relief on long-term follow-up. The authors present their recommendation for managing this complex group of patients. Keywords: Abdominal myofascial pain syndrome, abdominal plane blocks, chronic abdominal wall pain, opioid reduction, quadratus lumborum block, TAP block, viscerosomatic convergence


Author(s):  
Oscar D. Guillamondegui

Traumatic brain injury (TBI) is a serious epidemic in the United States. It affects patients of all ages, race, and socioeconomic status (SES). The current care of these patients typically manifests after sequelae have been identified after discharge from the hospital, long after the inciting event. The purpose of this article is to introduce the concept of identification and management of the TBI patient from the moment of injury through long-term care as a multidisciplinary approach. By promoting an awareness of the issues that develop around the acutely injured brain and linking them to long-term outcomes, the trauma team can initiate care early to alter the effect on the patient, family, and community. Hopefully, by describing the care afforded at a trauma center and by a multidisciplinary team, we can bring a better understanding to the armamentarium of methods utilized to treat the difficult population of TBI patients.


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