Suture-Based Debris Behavior in the Draining Lymph Nodes of a Porcine Knee: A Study of Silicone, Polyethylene and Carbon

Tuberculous pancreatitis complicated by ruptured splenic artery pseudoaneurysm. M. Irfan, F. Thiavalappil, J. Nagaraj, T.H. Brown, D. Roberts, L. Mcknight, N.K. Harrison. Tuberculosis involving the pancreas is rare. We report a patient with pancreatic tuberculosis complicated by haemorrhage from a splenic artery pseudoaneurysm. As far as we are aware, the development of a splenic artery pseudoaneurysm in association with a large caseating mass of tuberculous pancreatic lymph nodes has not been reported previously. We review the literature and discuss the varied presentations of tuberculosis involving the pancreas or the pancreatic bed and its draining lymph nodes.

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Mast cell–derived particles deliver peripheral signals to remote lymph nodes

Journal of Experimental Medicine ◽

10.1084/jem.20090805 ◽

2009 ◽

Vol 206 (11) ◽

pp. 2455-2467 ◽

Cited By ~ 115

Author(s):

Christian A. Kunder ◽

Ashley L. St. John ◽

Guojie Li ◽

Kam W. Leong ◽

Brent Berwin ◽

...

Keyword(s):

Drug Delivery ◽

Mast Cell ◽

Mast Cells ◽

Tumor Necrosis Factor ◽

Lymph Nodes ◽

Tumor Necrosis ◽

Lymphatic Vessels ◽

Lymphoid Tissues ◽

Draining Lymph Nodes ◽

Necrosis Factor

During infection, signals from the periphery are known to reach draining lymph nodes (DLNs), but how these molecules, such as inflammatory cytokines, traverse the significant distances involved without dilution or degradation remains unclear. We show that peripheral mast cells, upon activation, release stable submicrometer heparin-based particles containing tumor necrosis factor and other proteins. These complexes enter lymphatic vessels and rapidly traffic to the DLNs. This physiological drug delivery system facilitates communication between peripheral sites of inflammation and remote secondary lymphoid tissues.

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HETEROGENEITY OF ANTIBODY-FORMING CELLS

Journal of Experimental Medicine ◽

10.1084/jem.129.5.1029 ◽

1969 ◽

Vol 129 (5) ◽

pp. 1029-1044 ◽

Cited By ~ 19

Author(s):

Cesare Bosman ◽

Joseph D. Feldman ◽

Edgar Pick

Keyword(s):

Lymph Nodes ◽

Plasma Cells ◽

Specific Antigen ◽

Cell Suspensions ◽

Electron Microscopic ◽

Cytoplasmic Vacuoles ◽

Draining Lymph Nodes

Cell suspensions from draining lymph nodes of immune and nonimmune rats were reacted in vitro with 125I-labeled antigens. In light microscopic radioautographs of smears, 17% of the immunized cells were tagged by specific antigen; 2.0% of control cells were positive. In electron microscopic radioautographs, 90% of the labeled elements from immune donors were lymphocytes, blast and plasma cells; 10% were monocytes-macrophages or other elements, including naked nuclei. 15% of the labeled cells from control materials were lymphocytes and plasma cells, while 85% were monocytes-macrophages and naked nuclei. Within cell suspensions derived from immunized animals there were almost twice as many lymphocytes marked by isotope as plasma cells, and the lymphocytes ranged in morphology from mature monoribosomal elements to immature polyribosomal cells. Antibody-forming cells fixed labeled antigen at their surfaces. The monocyte-macrophage class was distinguished by a high mean grain count and by distribution of grains within cytoplasmic vacuoles and lysosomes.

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