Glycans signature in monocytes and lymphocytes from LDL-R KO mice and FH patients

2020 ◽  
Vol 315 ◽  
pp. e90
Author(s):  
R. Bellini ◽  
F. Bonacina ◽  
M. Svecla ◽  
F. Pellegatta ◽  
A.L. Catapano ◽  
...  
Keyword(s):  
Monocytes And Lymphocytes

scholarly journals DNA content of granulocytes, monocytes, and lymphocytes in the bone marrow smears of patients with myelodysplastic syndromes

2001 ◽  
Vol 67 (2) ◽  
pp. 112-118
Author(s):  
Susanne Widell ◽  
Robert Hast ◽  
Christopher Cox ◽  
Gert Auer ◽  
John M. Bennett
Keyword(s):  
Bone Marrow ◽  
Myelodysplastic Syndromes ◽  
Dna Content ◽  
Monocytes And Lymphocytes

scholarly journals Identification of phosphatidylserine-binding proteins in human white blood cells

1990 ◽  
Vol 269 (3) ◽  
pp. 723-728 ◽  
Author(s):  
M Wolf ◽  
M Baggiolini
Keyword(s):  
Protein Kinase C ◽  
Blood Cells ◽  
Binding Proteins ◽  
White Blood Cells ◽  
Human Neutrophils ◽  
Kinase C ◽  
Sds Page ◽  
Molecular Masses ◽  
Human White Blood Cells ◽  
Monocytes And Lymphocytes

Cytosol and membrane fractions from human neutrophils, monocytes, lymphocytes and platelets were separated by SDS/PAGE, blotted on to nitrocellulose and assayed for selective binding of phosphatidylserine (PS). Two PS-binding proteins with apparent molecular masses of 115 kDa and 100 kDa were identified in the cytosol of neutrophils, monocytes and lymphocytes. Corresponding bands along with other PS-binding proteins were detected in platelets in both cytosol and membrane fractions. These proteins were also found to bind protein kinase C (PKC) provided that PS was present. The 115 kDa and 100 kDa proteins (PS-p115/110) were partially purified from neutrophils and were used for the study of PS and PKC binding. The binding of PS did not require Ca2+ or Mg2+ and was inhibited by phosphatidic acid, by 1-alkyl-2-acetylphosphocholine and, to a lesser extent, by other lipids. The binding of PKC, however, was strictly PS- and Ca2(+)-dependent and seems to occur secondarily to PS binding.

Isolation of Human and Porcine Monocytes and Lymphocytes by three Parameter Flow Sorting*

1990 ◽  
Vol 37 (1-10) ◽  
pp. 585-591 ◽  
Author(s):  
Marijke de Gruijter ◽  
Marion A. Rijn ◽  
A. Verkerk ◽  
J. F. Jongkind
Keyword(s):  
Flow Sorting ◽  
Monocytes And Lymphocytes

scholarly journals Prognostic value of pretreatment circulating neutrophils, monocytes, and lymphocytes on outcomes in lung stereotactic body radiotherapy

2016 ◽  
Vol 23 (4) ◽  
pp. 362 ◽  
Author(s):  
M. Giuliani ◽  
L.R. Sampson ◽  
O. Wong ◽  
J. Gay ◽  
L.W. Le ◽  
...  
Keyword(s):  
Confidence Interval ◽  
Stereotactic Body Radiotherapy ◽  
Proportional Hazards ◽  
Complete Blood Count ◽  
Multivariable Analysis ◽  
Primary Lung Cancer ◽  
Cox Proportional Hazards ◽  
T Stage ◽  
Lung Sbrt ◽  
Monocytes And Lymphocytes

PurposeIn the present study, we determined the association of pretreatment circulating neutrophils, monocytes, and lymphocytes with clinical outcomes after lung stereotactic body radiotherapy (sbrt).Methods All patients with primary lung cancer and with a complete blood count within 3 months of lung sbrt from 2005 to 2012 were included. Overall survival (os) was calculated using the Kaplan–Meier method. Factors associated with os were investigated using univariable and multivariable Cox proportional hazards regression. Fine–Gray competing risk regression was performed to test the association of the neutrophil:lymphocyte (nlr) and monocyte:lymphocyte (mlr) ratios with two types of failure: disease-related failure and death, and death unrelated to disease.Results Of the 299 sbrt patients identified, 122 were eligible for analysis. The median and range of the nlr and mlr were 3.0 (0.3–22.0) and 0.4 (0.1–1.9) respectively. On multivariable analysis, sex (p = 0.02), T stage (p = 0.04), and nlr (p < 0.01) were associated with os. On multivariable analysis, T stage (p < 0.01) and mlr (p < 0.01) were associated with disease-related failure; mlr (p = 0.03), nlr (p < 0.01), and sbrt dose of 48 Gy in 4 fractions (p = 0.03) and 54 Gy or 60 Gy in 3 fractions (p = 0.02) were associated with disease-unrelated death. Median survival was 4.3 years in the nlr≤3 group (95% confidence interval: 3.5 to not reached) and 2.5 years in the nlr>3 group (95% confidence interval: 1.7 to 4.8; p < 0.01).Conclusions In lung sbrt patients, nlr and mlr are independently associated with os and disease-unrelated death. If validated, nlr and mlr could help to identify patients who would benefit most from sbrt.

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