Actin, tropomyosin and peroxiredoxin-2 in atherosclerotic plaques at different stages of development in coronary atherosclerosis

2021 ◽  
Vol 331 ◽  
pp. e102
Author(s):  
E.M. Stakhneva ◽  
I.A. Meshcheryakova ◽  
E.A. Demidov ◽  
K.V. Starostin ◽  
S.E. Peltek ◽  
...  
Keyword(s):  
Coronary Atherosclerosis ◽  
Atherosclerotic Plaques ◽  
Stages Of Development ◽  
Peroxiredoxin 2

Comparison in the proteoms of atherosclerotic plaques at different stages of development in coronary atherosclerosis

2020 ◽  
Vol 315 ◽  
pp. e113
Author(s):  
E. Stakhneva ◽  
I. Meshcheryakova ◽  
E. Demidov ◽  
K. Starostin ◽  
S. Peltek ◽  
...  
Keyword(s):  
Coronary Atherosclerosis ◽  
Atherosclerotic Plaques ◽  
Stages Of Development

scholarly journals A Proteomic Study of Atherosclerotic Plaques in Men with Coronary Atherosclerosis

Diagnostics ◽  
2019 ◽  
Vol 9 (4) ◽  
pp. 177 ◽  
Author(s):  
Ekaterina M. Stakhneva ◽  
Irina A. Meshcheryakova ◽  
Evgeny A. Demidov ◽  
Konstantin V. Starostin ◽  
Evgeny V. Sadovski ◽  
...  
Keyword(s):  
Coronary Arteries ◽  
Coronary Atherosclerosis ◽  
Serum Amyloid ◽  
Atherosclerotic Plaques ◽  
Amyloid P Component ◽  
Serum Amyloid P ◽  
Serum Amyloid P Component ◽  
Proteomic Study ◽  
Amyloid P ◽  
Β Chain

Background: To study the changes in protein composition of atherosclerotic plaques at different stages of their development in coronary atherosclerosis using proteomics. Methods: The object of research consisted of homogenates of atherosclerotic plaques from coronary arteries at different stages of development, obtained from 15 patients. Plaque proteins were separated by two-dimensional electrophoresis. The resultant protein spots were identified by the matrix-assisted laser desorption ionization method with peptide mass mapping. Results: Groups of differentially expressed proteins, in which the amounts of proteins differed more than twofold (p < 0.05), were identified in pools of homogenates of atherosclerotic plaques at three stages of development. The amounts of the following proteins were increased in stable atherosclerotic plaques at the stage of lipidosis and fibrosis: vimentin, tropomyosin β-chain, actin, keratin, tubulin β-chain, microfibril-associated glycoprotein 4, serum amyloid P-component, and annexin 5. In plaques at the stage of fibrosis and calcification, the amounts of mimecan and fibrinogen were increased. In unstable atherosclerotic plaque of the necrotic–dystrophic type, the amounts of human serum albumin, mimecan, fibrinogen, serum amyloid P-component and annexin were increased. Conclusion: This proteomic study identifies the proteins present in atherosclerotic plaques of coronary arteries by comparing their proteomes at three different stages of plaque development during coronary atherosclerosis.

The Blood Biomarkers Associated With Unstable Atherosclerotic Plaques In Patients With Coronary Atherosclerosis

2019 ◽  
Vol 287 ◽  
pp. e278
Author(s):  
E. Kashtanova ◽  
Y. Polonskaya ◽  
E. Stakhneva ◽  
A. Kurguzov ◽  
I. Murashov ◽  
...  
Keyword(s):  
Coronary Atherosclerosis ◽  
Atherosclerotic Plaques ◽  
Blood Biomarkers

The Fatty Acids Composition In Patients With Coronary Atherosclerosis And Unstable Atherosclerotic Plaques

2019 ◽  
Vol 287 ◽  
pp. e163
Author(s):  
V. Shramko ◽  
Y. Ragino ◽  
E. Kashtanova ◽  
Y. Polonskaya ◽  
S. Morozov ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Coronary Atherosclerosis ◽  
Atherosclerotic Plaques ◽  
Fatty Acids Composition

scholarly journals Analysis of differential expression of lipid metabolism genes in atherosclerotic plaques in patients with coronary atherosclerosis

2022 ◽  
Vol 36 (4) ◽  
pp. 156-163
Author(s):  
E. V. Shakhtshneider ◽  
D. E. Ivanoshchuk ◽  
Yu. I. Ragino ◽  
V. S. Fishman ◽  
Ya. V. Polonskaya ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Differential Expression ◽  
Coronary Atherosclerosis ◽  
Functional Class ◽  
Atherosclerotic Plaques ◽  
Old Patients ◽  
Expression Levels ◽  
Coronary Syndrome ◽  
Different Types ◽  
Lipid Metabolism Genes

Aim. The goal of the study was to analyze the differential expression of lipid metabolism-related genes in the atherosclerotic plaques of different types in patients with coronary atherosclerosis.Material and Methods. The study was performed on the specimens of atherosclerotic plaques in 45–65-year-old patients with coronary atherosclerosis with stable exertional angina functional class II-IV without acute coronary syndrome. Coronary atherosclerosis was verified by coronary angiography. Atherosclerotic plaque tissue was sampled intraoperatively when indicated. Whole-genome sequencing of ribonucleic acid (RNA) was performed using the TruSeq RNA Sample Preparation Kit (Illumina, USA).Results. We analyzed the differences in the expression of 12 genes including LDLR, APOB, PCSK9, LDLRAP1, LIPA, STAP1, ABCA1, APOA1, APOE, LPL, SCARB1, and SREBF2 depending on the type of atherosclerotic plaques. The expression level of APOE gene was eight times higher in unstable atherosclerotic plaques of dystrophic-necrotic type (p < 0.0001). The expression levels of LDLR and APOB genes were eight times higher in stable atherosclerotic plaques (p < 0.0001). We did not find differences in the expression levels of the ABCG5, ABCG8, APOC3, CETP, CLPS, CYP7A1, and PNPLA5 genes.Conclusion. The study showed the differences in the activity of individual metabolism-related genes in the atherosclerotic plaques of different types in patients with coronary atherosclerosis. Obtained data may become the basis for the development of test systems aimed at predicting the development of atherosclerotic process and its complications.

Temperature Measurement of Advanced Murine Atherosclerotic Plaques

2007 ◽  
Author(s):  
Frank Gijsen ◽  
Anna Ten Have ◽  
Jolanda Wentzel ◽  
Antonius Van Der Steen
Keyword(s):  
Heart Disease ◽  
Vulnerable Plaque ◽  
Acute Coronary Syndromes ◽  
Coronary Atherosclerosis ◽  
Developmental Stages ◽  
Atherosclerotic Plaques ◽  
Fibrous Cap ◽  
Vulnerable Plaques ◽  
Coronary Syndromes ◽  
Plaque Detection

Ischaemic heart disease is most frequently caused by coronary atherosclerosis, of which the vulnerable plaque is one of the developmental stages. Rupture of a vulnerable plaque with superimposed thrombosis frequently leads to acute coronary syndromes. The major components of a vulnerable plaque are a lipid-rich, atheromatous core, and a thin fibrous cap with macrophage and macrophage infiltration (Schaar et al., 2004). After the first paper suggesting the possibility of thermographic detection of vulnerable plaques (Casscells et al., 1996), intracoronary thermography as a vulnerable plaque detection technique has been investigated. Increased metabolic activity of macrophages is suggested as the main reasons for the increased temperatures (ten Have et al., 2005).

scholarly journals CALCULATOR OF NON-OBSTRUCTIVE CORONARY ATHEROSCLEROSIS: CLINICAL CASE OF A MALE PATIENT WITH SUSPECTED CORONARY ARTERY DISEASE

2018 ◽  
Vol 33 (3) ◽  
pp. 93-101 ◽  
Author(s):  
E. I. Yaroslavskaya ◽  
V. A. Kuznetsov ◽  
E. A. Gorbatenko ◽  
S. M. Dyachkov
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Atherosclerosis ◽  
Suspected Coronary Artery Disease ◽  
Myocardial Infarctions ◽  
Lipid Lowering ◽  
Atherosclerotic Plaques ◽  
Lipid Lowering Therapy ◽  
Patient Gender ◽  
Artery Disease

Evidence suggests that most myocardial infarctions result from ruptures of the atherosclerotic plaques that do not significantly compromise coronary lumen before the event. However, detection of nonsignificant coronary lesions in patients with suspected coronary artery disease without coronary angiography is challenging. We developed a calculator for nonobstructive coronary atherosclerosis based on patient gender, age, and the presence or absence of the echocardiographic signs of ascending aorta atherosclerosis and arterial hypertension. The calculator may be used for determining the probability of non-obstructive coronary atherosclerosis and for promoting compliance of patients to lipid-lowering therapy.

scholarly journals Some morphological aspects of myocardial bridges

2021 ◽  
Vol 64 (2) ◽  
pp. 58-64
Author(s):  
Mihail Tasnic ◽  
◽  
Ilia Catereniuc ◽  
Keyword(s):  
Coronary Arteries ◽  
Coronary Atherosclerosis ◽  
Obstructive Coronary Artery Disease ◽  
Left Ventricular ◽  
Atherosclerotic Plaques ◽  
Vascular Compression ◽  
Myocardial Bridges ◽  
Research Findings ◽  
Artery Disease ◽  
The Comparative Study

Background: Myocardial bridges are variants of the intramyocardial position of the coronary arteries. In the specialty literature, hot topics in cardiovascular field are myocardial infarction and non-obstructive coronary artery disease with frequent connection with myocardial bridges. Material and methods: The morphological study was based on the analysis of 200 human hearts and fragments of coronary arteries. The retrospective study was focused on the analysis of 6168 coronary angiography reports, to identify patients with myocardial bridges, their preferred location, the degree of systolic stenosis, the association between myocardial bridges and proximal to bridge and under the bridge coronary atherosclerosis. Results: The complete myocardial bridges were described in 62% of the analyzed hearts and only in 5.3% of the total number of studied coronarographies. In the majority of cases, the complete myocardial bridges covered the anterior interventricular branch. The degree of subpontine arterial systolic stenosis varied within 10-95%. The comparative study did not determine any correlations between the degree of subpontine vascular compression and the degree of the left ventricular myocardial hypertrophy. In 32% of cases were described proximal to bridge atherosclerotic plaques and only in one case (0.5%) – distal to bridge atherosclerotic plaques, located immediately under the bridge. Conclusions: The research findings underline the differences in anatomical and angiographic incidence of myocardial bridges, and the inability of all bridges to reduce the lumen of under bridged artery. Current study emphasizes attention to the topography of bridges, the correlation with ventricular hypertrophy and coronary atherosclerosis.

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