Intermediate stage atherosclerosis regression, using combination atorvastatin loaded microbubbles- mediated focused ultrasound sonoporation therapy and lipid based encapsulated gold nanoparticles- mediated X- rays- based auger electron therapy

This study examined the effects of gold nanoparticles (AuNPs) and/or ionizing radiation (IR) on the viability and motility of human primary colon epithelial (CCD841) and colorectal adenocarcinoma (SW48) cells as well as human primary epidermal melanocytes (HEM) and melanoma (MM418-C1) cells. AuNPs up to 4 mM had no effect on the viability of these cell lines. The viability of the cancer cells was ~60% following exposure to 5 Gy. Exposure to 5 Gy X-rays or 1 mM AuNPs showed the migration of the cancer cells ~85% that of untreated controls, while co-treatment with AuNPs and IR decreased migration to ~60%. In the non-cancerous cell lines gap closure was enhanced by ~15% following 1 mM AuNPs or 5 Gy treatment, while for co-treatment it was ~22% greater than that for the untreated controls. AuNPs had no effect on cell re-adhesion, while IR enhanced only the re-adhesion of the cancer cell lines but not their non-cancerous counterparts. The addition of AuNPs did not enhance cell adherence. This different reaction to AuNPs and IR in the cancer and normal cells can be attributed to radiation-induced adhesiveness and metabolic differences between tumour cells and their non-cancerous counterparts.

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AES and ToF-SIMS combination for single cell chemical imaging of gold nanoparticle-labeled Escherichia coli

Chemical Communications ◽

10.1039/d1cc01211h ◽

2021 ◽

Author(s):

Cecile COURREGES ◽

Mélanie Bonnecaze ◽

Delphine Flahaut ◽

Sophie Nolivos ◽

Regis Grimaud ◽

...

Keyword(s):

Escherichia Coli ◽

Gold Nanoparticles ◽

Single Cell ◽

Electron Spectroscopy ◽

Auger Electron ◽

Chemical Imaging ◽

Single Cell Level ◽

Cell Level ◽

Tof Sims ◽

Escherichia Coli Cells

A chemical fingerprint of Escherichia coli cells surface labeled by gelatin coated gold nanoparticles was obtained by combining Auger Electron Spectroscopy (AES) for single cell level chemical images, and Time-of-Flight...

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Intercomparison of Monte Carlo calculated dose enhancement ratios for gold nanoparticles irradiated by X-rays: Assessing the uncertainty and correct methodology for extended beams

Physica Medica ◽

10.1016/j.ejmp.2021.03.005 ◽

2021 ◽

Cited By ~ 1

Author(s):

H. Rabus ◽

W.B. Li ◽

C. Villagrasa ◽

J. Schuemann ◽

P.A. Hepperle ◽

...

Keyword(s):

Gold Nanoparticles ◽

Monte Carlo ◽

X Rays ◽

Dose Enhancement ◽

Calculated Dose

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165Er: A new candidate for Auger electron therapy and its possible cyclotron production from natural holmium targets

Applied Radiation and Isotopes ◽

10.1016/j.apradiso.2020.109079 ◽

2020 ◽

Vol 159 ◽

pp. 109079

Author(s):

Nadezda Gracheva ◽

Tommaso Stefano Carzaniga ◽

Roger Schibli ◽

Saverio Braccini ◽

Nicholas P. van der Meulen

Keyword(s):

Auger Electron ◽

Cyclotron Production ◽

Electron Therapy

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Corrigendum to “Intercomparison of dose enhancement ratio and secondary electron spectra for gold nanoparticles irradiated by X-rays calculated using multiple Monte Carlo simulation codes” [Phys. Med. 69 (2020) 147–163]

Physica Medica ◽

10.1016/j.ejmp.2020.10.008 ◽

2020 ◽

Vol 80 ◽

pp. 383-388

Author(s):

W.B. Li ◽

M. Beuve ◽

S. Di Maria ◽

W. Friedland ◽

B. Heide ◽

...

Keyword(s):

Monte Carlo Simulation ◽

Gold Nanoparticles ◽

Monte Carlo ◽

Secondary Electron ◽

X Rays ◽

Enhancement Ratio ◽

Dose Enhancement ◽

Electron Spectra ◽

Simulation Codes

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The effects of gold nanoparticles concentrations and beam quality/LET on dose enhancement when irradiated with X-rays and protons using alanine/EPR dosimetry

Radiation Measurements ◽

10.1016/j.radmeas.2017.01.019 ◽

2017 ◽

Vol 106 ◽

pp. 352-356 ◽

Cited By ~ 5

Author(s):

Clare L. Smith ◽

Stephen P. Best ◽

Frank Gagliardi ◽

Takahiro Tominaga ◽

Moshi Geso

Keyword(s):

Gold Nanoparticles ◽

Beam Quality ◽

X Rays ◽

Dose Enhancement ◽

Epr Dosimetry

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Microanalysis with Ultrasoft X-Radiations*

Advances in X-ray Analysis ◽

10.1154/s0376030800001646 ◽

1961 ◽

Vol 5 ◽

pp. 285-305 ◽

Cited By ~ 5

Author(s):

Burton L. Henke

Keyword(s):

Preliminary Report ◽

Auger Electron ◽

Low Energy ◽

Diffraction Reflection ◽

X Rays ◽

Electron Spectrometer ◽

Recent Developments ◽

New Type ◽

Low Energy Electron ◽

A Current

AbstractThe diffraction, reflection, absorption, fluorescence, and the electronic emission that results from the interaction with ultrasoft X-rays (λ > 10 A) are presented as practical bases for microanalysis. Recent developments on sources and detectors for the ultrasoft X-radiations are described. A preliminary report on a current investigation on low-energy photo-Auger electron analysis and on a new type of low-energy electron spectrometer is also presented.

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