Abstract. We use a global coupled chemistry-climate-land model (CESM) to assess the integrated effect of climate, emissions and land use changes on annual surface O3 and PM2.5 on the United States with a focus on National Parks (NPs) and wilderness areas, using the RCP4.5 and RCP8.5 projections. We show that, when stringent domestic emission controls are applied, air quality is predicted to improve across the US, except surface O3 over the western and central US under RCP8.5 conditions, where rising background ozone counteracts domestic emissions reductions. Under the RCP4.5, surface O3 is substantially reduced (about 5 ppb), with daily maximum 8 h averages below the primary US EPA NAAQS of 75 ppb (and even 65 ppb) in all the NPs. PM2.5 is significantly reduced in both scenarios (4 μg m−3; ~50%), with levels below the annual US EPA NAAQS of 12 μg m−3 across all the NPs; visibility is also improved (10–15 deciviews; >75 km in visibility range), although some parks over the western US (40–74% of total sites in the US) may not reach the 2050 target to restore visibility to natural conditions by 2064. We estimate that climate-driven increases in fire activity may dominate summertime PM2.5 over the western US, potentially offsetting the large PM2.5 reductions from domestic emission controls, and keeping visibility at present-day levels in many parks. Our study suggests that air quality in 2050 will be primarily controlled by anthropogenic emission patterns. However, climate and land use changes alone may lead to a substantial increase in surface O3 (2–3 ppb) with important consequences for O3 air quality and ecosystem degradation at the US NPs. Our study illustrates the need to consider the effects of changes in climate, vegetation, and fires in future air quality management and planning and emission policy making.