scholarly journals Oligomeric states of the SecA and SecYEG core components of the bacterial Sec translocon

2007 ◽  
Vol 1768 (1) ◽  
pp. 5-12 ◽  
Author(s):  
Sharyn L. Rusch ◽  
Debra A. Kendall
Keyword(s):  
Core Components ◽  
Sec Translocon

Secondary prevention in the clinical management of patients with cardiovascular diseases. Core components, standards and outcome measures for referral and delivery

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Economic Growth ◽  
Developing Countries ◽  
Clinical Practice ◽  
Cardiovascular Diseases ◽  
Secondary Prevention ◽  
Health Authorities ◽  
Overwhelming Evidence ◽  
Core Components ◽  
Interventional Therapies ◽  
Limited Period

Despite major improvements in diagnostics and interventional therapies, cardiovascular diseases remain a major healthcare and socio-economic burden both in western and developing countries, in which this burden is increasing in closecorrelation to economic growth. Health authorities and the general population have started to recognize that the fightagainst these diseases can only be won if their burden is faced by increasing our investment on interventions in lifestylechanges and prevention. There is an overwhelming evidence of the efficacy of secondary prevention initiatives includingcardiac rehabilitation in terms of reduction in morbidity and mortality. However, secondary prevention is still too poorlyimplemented in clinical practice, often only on selected populations and over a limited period of time. The developmentof systematic and full comprehensive preventive programmes is warranted, integrated in the organization ofnational health systems. Furthermore, systematic monitoring of the process of delivery and outcomes is a necessity.

CARPENTER 430FR SOLENOID QUALITY

Alloy Digest ◽  
1977 ◽  
Vol 26 (3) ◽  
Keyword(s):  
Stainless Steel ◽  
Electrical Resistivity ◽  
Magnetic Circuit ◽  
Iron Alloy ◽  
Heat Treating ◽  
Solenoid Valve ◽  
Magnetic Flux Density ◽  
Magnetic Components ◽  
Electromagnetic Relay ◽  
Core Components

Abstract Carpenter 430FR Solenoid Quality stainless steel is a ferritic chromium-iron alloy developed especially for A.C. and D.C. magnetic circuit applications such as solenoid valve core components and electromagnetic relay cores. The electrical resistivity of 430FR is approximately 25% higher than other commercially available 430F stainless. Increased electrical resistivity provides better performance of magnetic components, particularly at power frequencies and high magnetic flux density. This datasheet provides information on composition, physical properties, and hardness. It also includes information on corrosion resistance as well as forming, heat treating, machining, and joining. Filing Code: SS-337. Producer or source: Carpenter.

A chronology of Distributed Adaptive Control

2018 ◽  
Author(s):  
Paul F. M. J. Verschure
Keyword(s):  
Adaptive Control ◽  
Human Robot Interaction ◽  
Integration Framework ◽  
The Social ◽  
Distributed Adaptive Control ◽  
Core Components ◽  
Mind And Brain ◽  
Convergent Validation ◽  
The Mind ◽  
And Behavior

This chapter presents the Distributed Adaptive Control (DAC) theory of the mind and brain of living machines. DAC provides an explanatory framework for biological brains and an integration framework for synthetic ones. DAC builds on several themes presented in the handbook: it integrates different perspectives on mind and brain, exemplifies the synthetic method in understanding living machines, answers well-defined constraints faced by living machines, and provides a route for the convergent validation of anatomy, physiology, and behavior in our explanation of biological living machines. DAC addresses the fundamental question of how a living machine can obtain, retain, and express valid knowledge of its world. We look at the core components of DAC, specific benchmarks derived from the engagement with the physical and the social world (the H4W and the H5W problems) in foraging and human–robot interaction tasks. Lastly we address how DAC targets the UTEM benchmark and the relation with contemporary developments in AI.

Rhythmic Pattern Generation in Invertebrates

2018 ◽  
pp. 390-400
Author(s):  
Astrid A. Prinz
Keyword(s):  
Central Pattern Generators ◽  
Pattern Generation ◽  
Rhythmic Pattern ◽  
Neuronal Circuit ◽  
Neuronal Circuits ◽  
Timing Circuit ◽  
Core Components ◽  
Pattern Generators

This chapter begins by defining central pattern generators (CPGs) and proceeds to focus on one of their core components, the timing circuit. After arguing why invertebrate CPGs are particularly useful for the study of neuronal circuit operation in general, the bulk of the chapter then describes basic mechanisms of CPG operation at the cellular, synaptic, and network levels, and how different CPGs combine these mechanisms in various ways. Finally, the chapter takes a semihistorical perspective to discuss whether or not the study of invertebrate CPGs has seen its prime and what it has contributed—and may continue to offer—to a wider understanding of neuronal circuits in general.

scholarly journals Ultralow magnetostrictive flexible ferromagnetic nanowires

Nanoscale ◽  
2021 ◽  
Author(s):  
Giuseppe Muscas ◽  
Petra Jönsson ◽  
Ismael Garcia Serrano ◽  
Örjan Vallin ◽  
M. Venkata Kamalakar
Keyword(s):  
Flexible Electronics ◽  
Magnetic Nanowires ◽  
Wearable Technologies ◽  
Ferromagnetic Nanowires ◽  
Core Components

The integration of magneto-electric and spintronic sensors to flexible electronics presents massive potential for advancing flexible and wearable technologies. Magnetic nanowires are core components for building such devices. Therefore, realizing...

scholarly journals Hakai is required for stabilization of core components of the m6A mRNA methylation machinery

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Praveen Bawankar ◽  
Tina Lence ◽  
Chiara Paolantoni ◽  
Irmgard U. Haussmann ◽  
Migle Kazlauskiene ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Sex Determination ◽  
Ubiquitin Ligase ◽  
Mammalian Cells ◽  
E3 Ubiquitin Ligase ◽  
Human Cells ◽  
Biological Functions ◽  
Mrna Metabolism ◽  
Mrna Methylation ◽  
Core Components

AbstractN6-methyladenosine (m6A) is the most abundant internal modification on mRNA which influences most steps of mRNA metabolism and is involved in several biological functions. The E3 ubiquitin ligase Hakai was previously found in complex with components of the m6A methylation machinery in plants and mammalian cells but its precise function remained to be investigated. Here we show that Hakai is a conserved component of the methyltransferase complex in Drosophila and human cells. In Drosophila, its depletion results in reduced m6A levels and altered m6A-dependent functions including sex determination. We show that its ubiquitination domain is required for dimerization and interaction with other members of the m6A machinery, while its catalytic activity is dispensable. Finally, we demonstrate that the loss of Hakai destabilizes several subunits of the methyltransferase complex, resulting in impaired m6A deposition. Our work adds functional and molecular insights into the mechanism of the m6A mRNA writer complex.

Sign in / Sign up

Export Citation Format

Share Document