The novel and potent anti-depressive action of triptolide and its influences on hippocampal neuroinflammation in a rat model of depression comorbidity of chronic pain

2017 ◽  
Vol 64 ◽  
pp. 180-194 ◽  
Author(s):  
Xiaofan Hu ◽  
Yulin Dong ◽  
Xiaohang Jin ◽  
Chunkui Zhang ◽  
Ting Zhang ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Rat Model ◽  
The Novel

scholarly journals The acquisition and generalization of fear of touch

2020 ◽  
Vol 20 (4) ◽  
pp. 809-819 ◽  
Author(s):  
Emma E. Biggs ◽  
Ann Meulders ◽  
Amanda L. Kaas ◽  
Rainer Goebel ◽  
Johan W. S. Vlaeyen
Keyword(s):  
Chronic Pain ◽  
Stimulus Generalization ◽  
Spontaneous Pain ◽  
The Novel ◽  
Vibrotactile Stimulation ◽  
Differential Acquisition ◽  
New Locations ◽  
Conditioned Responses ◽  
Primary Focus ◽  
Post Hoc

AbstractObjectivesContemporary fear-avoidance models of chronic pain posit that fear of pain, and overgeneralization of fear to non-threatening stimuli is a potential pathway to chronic pain. While increasing experimental evidence supports this hypothesis, a comprehensive investigation requires testing in multiple modalities due to the diversity of symptomatology among individuals with chronic pain. In the present study we used an established tactile fear conditioning paradigm as an experimental model of allodynia and spontaneous pain fluctuations, to investigate whether stimulus generalization occurs resulting in fear of touch spreading to new locations.MethodsIn our paradigm, innocuous touch is presented either paired (predictable context) or unpaired (unpredictable context) with a painful electrocutaneous stimulus (pain-US). In the predictable context, vibrotactile stimulation to the index or little finger was paired with the pain-US (CS+), whilst stimulation of the other finger was never paired with pain (CS−). In the unpredictable context, vibrotactile stimulation to the index and little fingers of the opposite hand (CS1 and CS2) was unpaired with pain, but pain-USs occurred unpredictable during the intertrial interval. During the subsequent generalization phase, we tested the spreading of conditioned responses (self-reported fear of touch and pain expectancy) to the (middle and ring) fingers between the CS+ and CS−, and between the CS1 and CS2.ResultsDifferential fear acquisition was evident in the predictable context from increased self-reported pain expectancy and self-reported fear for the CS + compared to the CS−. However, expectancy and fear ratings to the novel generalization stimuli (GS+ and GS−) were comparable to the responses elicited by the CS−. Participants reported equal levels of pain expectancy and fear to the CS1 and CS2 in the unpredictable context. However, the acquired fear did not spread in this context either: participants reported less pain expectancy and fear to the GS1 and GS2 than to the CS1 and CS2. As in our previous study, we did not observe differential acquisition in the startle responses.ConclusionsWhilst our findings for the acquisition of fear of touch replicate the results from our previous study (Biggs et al., 2017), there was no evidence of fear generalization. We discuss the limitations of the present study, with a primary focus on procedural issues that were further investigated with post-hoc analyses, concluding that the present results do not show support for the hypothesis that stimulus generalization underlies spreading of fear of touch to new locations, and discuss how this may be the consequence of a context change that prevented transfer of acquisition.

scholarly journals Authenticity as a Resilience Factor Against CV-19 Threat Among Those With Chronic Pain and Posttraumatic Stress Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
David E. Reed ◽  
Elizabeth Lehinger ◽  
Briana Cobos ◽  
Kenneth E. Vail ◽  
Paul S. Nabity ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Chronic Pain ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Brief Pain Inventory ◽  
The Novel ◽  
Ptsd Symptoms ◽  
Physical Conditions ◽  
Resilience Factors ◽  
Novel Coronavirus

ObjectiveThe novel coronavirus (2019; CV-19) is linked to increases in emotional distress and may be particularly problematic for those with pre-existing mental and physical conditions, such as chronic pain and posttraumatic stress disorder (PTSD). However, little empirical research has been published on resilience factors in these individuals. The present study aims to examine authenticity as a resilience factor among those with chronic pain and/or PTSD.MethodsPrior to the national response to the pandemic (January 10-24, 2020), participants were screened for pain-related disability (Oswestry Disability Index; ODI) and PTSD symptoms (Posttraumatic Checklist for DSM-5; PCL-5), and on the basis of those responses were categorized into one of four groups: healthy, chronic pain only, PTSD only, or comorbid chronic pain and PTSD. During the CV-19 pandemic (May 5-May 13, 2020), participants responded again to the ODI and PCL-5, in addition to the Wood Authenticity Scale, Brief Pain Inventory, and items related to the CV-19 pandemic.ResultsA total of 110 participants (54.55% women), aged 42.19 (SD = 13.16), completed the survey during the pandemic. The comorbid group endorsed higher levels of CV-19 Threat and Impact compared to all other groups. Authenticity moderated this relationship relevant to CV-19 Threat among those in the chronic pain only group, and not in any other group.ConclusionThe comorbid group endorsed higher levels of CV-19 Threat and Impact compared to all other groups. Importantly, greater authenticity was associated with less CV-19 Threat in the chronic pain only group, and not in any other group. The present study also highlights the importance of engaging authentically for those with chronic pain during the pandemic.

scholarly journals Curcumin Improves Chronic Pain Induced Depression Through Regulating Serum Metabolomics in a Rat Model of Trigeminal Neuralgia

2020 ◽  
Vol Volume 13 ◽  
pp. 3479-3492
Author(s):  
Li Zhang ◽  
Zhijie Ma ◽  
Zhe Wu ◽  
Mu Jin ◽  
Lixin An ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Trigeminal Neuralgia ◽  
Rat Model ◽  
Serum Metabolomics

scholarly journals Rapamycin alleviates inflammation and muscle weakness, while altering the Treg/Th17 balance in a rat model of myasthenia gravis

2017 ◽  
Vol 37 (4) ◽  
Author(s):  
Feng Jing ◽  
Fei Yang ◽  
Fang Cui ◽  
Zhaohui Chen ◽  
Li Ling ◽  
...  
Keyword(s):  
T Cells ◽  
Autoimmune Disease ◽  
Myasthenia Gravis ◽  
Rat Model ◽  
Th17 Cells ◽  
Mortality Rates ◽  
The Novel ◽  
Muscular Weakness ◽  
Body Weights ◽  
Experimental Autoimmune

Myasthenia gravis (MG) is an autoimmune disease commonly treated with immunosuppressants. We evaluated the novel immunosuppressant, rapamycin (RAPA), in a rat model of experimental autoimmune MG (EAMG). Mortality rates in the RAPA (12%) were significantly down compared with the EAMG (88%) or cyclophosphamide (CTX) (68%) intervention groups. Muscular weakness decreased after both RAPA and CTX treatment. However, Lennon scores were lower (1.74 ± 0.49, 3.39 ± 0.21, and 3.81 ± 0.22 in RAPA, CTX, and EAMG groups, respectively), and body weights (203.12 ± 4.13 g, 179.23 ± 2.13 g, and 180.13 ± 5.13 g in RAPA, CTX, and EAMG groups, respectively) were significantly higher, only in the RAPA group. The proportion of regulatory T cells (Treg) significantly increased, while that of Th17 cells significantly decreased in the RAPA group compared with the EAMG group. In comparison, CTX intervention resulted in increased Th17 but significantly decreased Tregs. Hence, RAPA can be more effectively used in comparison with CTX to treat MG, with an efficacy higher than that of CTX. In addition, our results suggest RAPA’s efficacy in alleviating symptoms of MG stems from its ability to correct the Treg/Th17 imbalance observed in MG.

Distinct changes in chronic pain sensitivity and oxytocin receptor expression in a new rat model (Wisket) of schizophrenia

2020 ◽  
Vol 714 ◽  
pp. 134561 ◽  
Author(s):  
László Banki ◽  
Alexandra Büki ◽  
Gyongyi Horvath ◽  
Gabriella Kekesi ◽  
Gyongyi Kis ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Rat Model ◽  
Pain Sensitivity ◽  
Oxytocin Receptor ◽  
Receptor Expression

scholarly journals Effect of the novel histamine H 4 receptor antagonist SENS‐111 on spontaneous nystagmus in a rat model of acute unilateral vestibular loss

2019 ◽  
Vol 177 (3) ◽  
pp. 623-633 ◽  
Author(s):  
Mathieu Petremann ◽  
Cindy Gueguen ◽  
Viviana Delgado Betancourt ◽  
Eric Wersinger ◽  
Jonas Dyhrfjeld‐Johnsen
Keyword(s):  
Receptor Antagonist ◽  
Rat Model ◽  
Spontaneous Nystagmus ◽  
The Novel ◽  
Vestibular Loss

In vivo efficacy of the novel hemostatic agent Poly DHA in an experimental rat model

2009 ◽  
Vol 62 (6) ◽  
pp. 833S-834S
Author(s):  
D.J. Kadouch ◽  
P. Henderson ◽  
S.P. Singh ◽  
P.N. Zawaneh ◽  
D. Putnam ◽  
...  
Keyword(s):  
Rat Model ◽  
Hemostatic Agent ◽  
The Novel ◽  
In Vivo Efficacy ◽  
Experimental Rat Model

DIFFERENTIAL EFFECT OF MORPHINE ON ALLODYNIA AND HYPERALGESIA IN A RAT MODEL OF CHRONIC PAIN CREATED BY SCIATIC NERVE LIGATION

1992 ◽  
Vol 77 (Supplement) ◽  
pp. A844
Author(s):  
E N Tanck ◽  
J S Kroin ◽  
R J McCarthy ◽  
A D Ivankovich
Keyword(s):  
Chronic Pain ◽  
Sciatic Nerve ◽  
Rat Model ◽  
Differential Effect

Codetron in Rehabilitation of Chronic Pain Patients

1989 ◽  
Vol 6 (2) ◽  
pp. 54-56 ◽  
Author(s):  
Angelica Fargas-Babjak
Keyword(s):  
Clinical Trial ◽  
Chronic Pain ◽  
Transcutaneous Electrical Nerve Stimulation ◽  
Modern Medicine ◽  
Pain Clinic ◽  
The Novel ◽  
Technological Changes ◽  
Electrical Nerve Stimulation ◽  
Chronic Pain Patients ◽  
Pain Patients

Acupuncture is one of the oldest healing methods which is used in traditional medicine. in modern medicine we are witnessing a renaissance of this ancient treatment applied mainly in the management of chronic pain. A number of modern technological changes are being applied to replace, or modify, the classical needle treatment Among many of the modalities used at present are light, in the form of laser, and electrical stimulation. CODETRON TENS, the novel addition to Transcutaneous Electrical Nerve Stimulation (TENS), has been evaluated in a clinical trial, over a two year period, in a multidisciplinary pain clinic on patients who came for acupuncture therapy. Indications, effectiveness and experiences with this form of treatment are presented.

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