scholarly journals The acquisition and generalization of fear of touch

2020 ◽  
Vol 20 (4) ◽  
pp. 809-819 ◽  
Author(s):  
Emma E. Biggs ◽  
Ann Meulders ◽  
Amanda L. Kaas ◽  
Rainer Goebel ◽  
Johan W. S. Vlaeyen
Keyword(s):  
Chronic Pain ◽  
Stimulus Generalization ◽  
Spontaneous Pain ◽  
The Novel ◽  
Vibrotactile Stimulation ◽  
Differential Acquisition ◽  
New Locations ◽  
Conditioned Responses ◽  
Primary Focus ◽  
Post Hoc

AbstractObjectivesContemporary fear-avoidance models of chronic pain posit that fear of pain, and overgeneralization of fear to non-threatening stimuli is a potential pathway to chronic pain. While increasing experimental evidence supports this hypothesis, a comprehensive investigation requires testing in multiple modalities due to the diversity of symptomatology among individuals with chronic pain. In the present study we used an established tactile fear conditioning paradigm as an experimental model of allodynia and spontaneous pain fluctuations, to investigate whether stimulus generalization occurs resulting in fear of touch spreading to new locations.MethodsIn our paradigm, innocuous touch is presented either paired (predictable context) or unpaired (unpredictable context) with a painful electrocutaneous stimulus (pain-US). In the predictable context, vibrotactile stimulation to the index or little finger was paired with the pain-US (CS+), whilst stimulation of the other finger was never paired with pain (CS−). In the unpredictable context, vibrotactile stimulation to the index and little fingers of the opposite hand (CS1 and CS2) was unpaired with pain, but pain-USs occurred unpredictable during the intertrial interval. During the subsequent generalization phase, we tested the spreading of conditioned responses (self-reported fear of touch and pain expectancy) to the (middle and ring) fingers between the CS+ and CS−, and between the CS1 and CS2.ResultsDifferential fear acquisition was evident in the predictable context from increased self-reported pain expectancy and self-reported fear for the CS + compared to the CS−. However, expectancy and fear ratings to the novel generalization stimuli (GS+ and GS−) were comparable to the responses elicited by the CS−. Participants reported equal levels of pain expectancy and fear to the CS1 and CS2 in the unpredictable context. However, the acquired fear did not spread in this context either: participants reported less pain expectancy and fear to the GS1 and GS2 than to the CS1 and CS2. As in our previous study, we did not observe differential acquisition in the startle responses.ConclusionsWhilst our findings for the acquisition of fear of touch replicate the results from our previous study (Biggs et al., 2017), there was no evidence of fear generalization. We discuss the limitations of the present study, with a primary focus on procedural issues that were further investigated with post-hoc analyses, concluding that the present results do not show support for the hypothesis that stimulus generalization underlies spreading of fear of touch to new locations, and discuss how this may be the consequence of a context change that prevented transfer of acquisition.

Insights into Transdermal Drug Delivery: Approaches for Redressal of a Burgeoning Issue of Osteoporosis

2020 ◽  
Vol 20 (10) ◽  
pp. 1682-1695
Author(s):  
Foziyah Zakir ◽  
Kanchan Kohli ◽  
Farhan J. Ahmad ◽  
Zeenat Iqbal ◽  
Adil Ahmad
Keyword(s):  
Drug Delivery ◽  
Transdermal Delivery ◽  
Oral Delivery ◽  
Calcium Absorption ◽  
Early Stage ◽  
Osteoporotic Fractures ◽  
The Novel ◽  
Systemic Delivery ◽  
Primary Focus ◽  
The Cost

Osteoporosis is a progressive bone disease that remains unnoticed until a fracture occurs. It is more predominant in the older age population, particularly in females due to reduced estrogen levels and ultimately limited calcium absorption. The cost burden of treating osteoporotic fractures is too high, therefore, primary focus should be treatment at an early stage. Most of the marketed drugs are available as oral delivery dosage forms. The complications, as well as patient non-compliance, limit the use of oral therapy for prolonged drug delivery. Transdermal delivery systems seem to be a promising approach for the delivery of anti-osteoporotic active moieties. One of the confronting barriers is the passage of drugs through the SC layers followed by penetration to deeper dermal layers. The review focuses on how anti-osteoporotic drugs can be molded through different approaches so that they can be exploited for the skin to systemic delivery. Insights into the various challenges in transdermal delivery and how the novel delivery system can be used to overcome these have also been detailed.

Nociceptors and Chronic Pain

2021 ◽  
Author(s):  
Edgar T. Walters
Keyword(s):  
Chronic Pain ◽  
Spontaneous Activity ◽  
Intracellular Signaling ◽  
Chronic Conditions ◽  
Spontaneous Pain ◽  
Pain Pathways ◽  
Low Threshold ◽  
Highly Correlated ◽  
Hyperalgesic Priming ◽  
Peripheral Activation

Chronic pain lasting months or longer is very common, poorly treated, and sometimes devastating. Nociceptors are sensory neurons that usually are silent unless activated by tissue damage or inflammation. In humans their peripheral activation evokes conscious pain, and their spontaneous activity is highly correlated with spontaneous pain. Persistently hyperactive nociceptors mediate increased responses to normally painful stimuli (hyperalgesia) in chronic conditions and promote the sensitization of central pain pathways that allows low-threshold mechanoreceptors to elicit painful responses to innocuous stimuli (allodynia). Investigations of rodent models of neuropathic pain and hyperalgesic priming have revealed many alterations in nociceptors and associated cells that are implicated in the development and maintenance of chronic pain. These include chronic nociceptor hyperexcitability and spontaneous activity, sprouting, synaptic plasticity, changes in intracellular signaling, and modified responses to opioids, along with alterations in the expression and translation of thousands of genes in nociceptors and closely linked cells.

Place–brand stereotypes: does stereotype-consistent messaging matter?

2018 ◽  
Vol 27 (7) ◽  
pp. 754-767
Author(s):  
Brittney C. Bauer ◽  
Clark D. Johnson ◽  
Nitish Singh
Keyword(s):  
Mediating Effect ◽  
The Novel ◽  
Perceived Fit ◽  
Experimental Conditions ◽  
Content Type ◽  
Global Brands ◽  
Place Brand ◽  
Foreign Brands ◽  
Improve Attitude ◽  
Post Hoc

Purpose The purpose of this paper is to address an overarching question: Does matching consumer place–brand associations with stereotype-consistent messaging affect consumer perceptions of an advertisement? Design/methodology/approach This paper presents two experiments that examine participants’ differing evaluations of advertisements under various experimental conditions. Study 1 examines the match of place–brand warmth versus competence stereotypes and the use of symbolic versus utilitarian advertising messaging for both new foreign and domestic brands. Study 2 examines this match for global brands. Findings The paper reveals that stereotype-consistent messaging increases the perceived fit between the advertisement and the brand for new foreign brands but not for new domestic or global brands. Furthermore, in a post-hoc analysis, this congruence is found to improve attitude towards the brand, purchase intentions and brand response, through the mediating effect of attitude towards the ad. Originality/value Place–brand stereotypes impact consumer attitudes and opinions regarding brands from different countries. This paper applies two universal social judgment dimensions from social psychology—warmth and competence—to the novel context of advertising messaging to examine previously unexplored facets of the place–brand image.

scholarly journals Authenticity as a Resilience Factor Against CV-19 Threat Among Those With Chronic Pain and Posttraumatic Stress Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
David E. Reed ◽  
Elizabeth Lehinger ◽  
Briana Cobos ◽  
Kenneth E. Vail ◽  
Paul S. Nabity ◽  
...  
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Chronic Pain ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Brief Pain Inventory ◽  
The Novel ◽  
Ptsd Symptoms ◽  
Physical Conditions ◽  
Resilience Factors ◽  
Novel Coronavirus

ObjectiveThe novel coronavirus (2019; CV-19) is linked to increases in emotional distress and may be particularly problematic for those with pre-existing mental and physical conditions, such as chronic pain and posttraumatic stress disorder (PTSD). However, little empirical research has been published on resilience factors in these individuals. The present study aims to examine authenticity as a resilience factor among those with chronic pain and/or PTSD.MethodsPrior to the national response to the pandemic (January 10-24, 2020), participants were screened for pain-related disability (Oswestry Disability Index; ODI) and PTSD symptoms (Posttraumatic Checklist for DSM-5; PCL-5), and on the basis of those responses were categorized into one of four groups: healthy, chronic pain only, PTSD only, or comorbid chronic pain and PTSD. During the CV-19 pandemic (May 5-May 13, 2020), participants responded again to the ODI and PCL-5, in addition to the Wood Authenticity Scale, Brief Pain Inventory, and items related to the CV-19 pandemic.ResultsA total of 110 participants (54.55% women), aged 42.19 (SD = 13.16), completed the survey during the pandemic. The comorbid group endorsed higher levels of CV-19 Threat and Impact compared to all other groups. Authenticity moderated this relationship relevant to CV-19 Threat among those in the chronic pain only group, and not in any other group.ConclusionThe comorbid group endorsed higher levels of CV-19 Threat and Impact compared to all other groups. Importantly, greater authenticity was associated with less CV-19 Threat in the chronic pain only group, and not in any other group. The present study also highlights the importance of engaging authentically for those with chronic pain during the pandemic.

Seducing-Machines

2016 ◽  
Author(s):  
Sean McQueen
Keyword(s):  
Middle Class ◽  
Film Adaptation ◽  
The Novel ◽  
Theoretical Approaches ◽  
Car Crashes ◽  
Primary Focus

This chapter turns to the 1973 J.G. Ballard novel Crash as well as its 1996 film adaptation by Cronenberg. It aims to make careful distinctions between Deleuze and Baudrillard and show why they gravitate to Crash. The primary focus in the novel is a cult of bored, middle-class professionals who feel alive only after modifying their bodies via staged car crashes. From here, the chapter reveals that Crash is notably quite flexible and can be subjected to many theoretical approaches, at times producing contradictory readings as a result. While Crash the novel might be a distinctly Baudrillardian creature, for example, Crash the Cronenberg film appears to lean more toward Deleuze.

The novel and potent anti-depressive action of triptolide and its influences on hippocampal neuroinflammation in a rat model of depression comorbidity of chronic pain

2017 ◽  
Vol 64 ◽  
pp. 180-194 ◽  
Author(s):  
Xiaofan Hu ◽  
Yulin Dong ◽  
Xiaohang Jin ◽  
Chunkui Zhang ◽  
Ting Zhang ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Rat Model ◽  
The Novel

A Power Dense Planetary Drive for Rotorcraft Applications

2013 ◽  
Author(s):  
Xiaolan Ai ◽  
Curtis Orkin ◽  
Randy Kruse
Keyword(s):  
Power Density ◽  
High Performance ◽  
Power Flow ◽  
Load Sharing ◽  
Advanced Materials ◽  
The Novel ◽  
Powertrain System ◽  
Planet Gear ◽  
Primary Focus ◽  
Rotary Wing

Increasing power density is an on-going objective for engineers of fixed wing and rotary wing aircraft. The powertrain system is one of the largest contributors to the total mass of the aircraft and the geartrain is the largest contributor to the mass of the powertrain system. As such, the geartrain becomes the primary focus of many power density studies and is the focus of this paper. Epicyclic geartrains are known to provide high power density and have become the geartrain of choice for the main power flow in virtually all aircraft designs. This paper presents a unique compound planetary design targeting a helicopter main gearbox transmission application. The design significantly improves power density through its innovative planet gear load-sharing configuration along with the utilization of high-performance materials for gears and bearings. Design studies were conducted comparing the power density of this new design to a baseline gearbox design. The results of these studies demonstrate an estimated 38% power density improvement over the baseline configuration. Of the total improvement, 86% is attributed to the novel load-sharing configuration while 14% is attributed to utilization of advanced materials and processes.

Codetron in Rehabilitation of Chronic Pain Patients

1989 ◽  
Vol 6 (2) ◽  
pp. 54-56 ◽  
Author(s):  
Angelica Fargas-Babjak
Keyword(s):  
Clinical Trial ◽  
Chronic Pain ◽  
Transcutaneous Electrical Nerve Stimulation ◽  
Modern Medicine ◽  
Pain Clinic ◽  
The Novel ◽  
Technological Changes ◽  
Electrical Nerve Stimulation ◽  
Chronic Pain Patients ◽  
Pain Patients

Acupuncture is one of the oldest healing methods which is used in traditional medicine. in modern medicine we are witnessing a renaissance of this ancient treatment applied mainly in the management of chronic pain. A number of modern technological changes are being applied to replace, or modify, the classical needle treatment Among many of the modalities used at present are light, in the form of laser, and electrical stimulation. CODETRON TENS, the novel addition to Transcutaneous Electrical Nerve Stimulation (TENS), has been evaluated in a clinical trial, over a two year period, in a multidisciplinary pain clinic on patients who came for acupuncture therapy. Indications, effectiveness and experiences with this form of treatment are presented.

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