The Role of Western Diets and Obesity in Peripheral Immune Cell Recruitment and Inflammation in the Central Nervous System

Disorders of the musculoskeletal system in school-age children occupy 1-2 places in the structure of functional abnormalities. Cognitive impairment without organic damage to the central nervous system is detected in 30-56% of healthy school children. Along with the increase in the incidence rate, the demand for rehabilitation systems, which allow patients to return to normal life as soon as possible and maintain the motivation for the rehabilitation process, is also growing. Adaptation of rehabilitation techniques, ease of equipment management, availability of specially trained personnel and availability of technical support for complexes becomes important.

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Faculty Opinions recommendation of The role of myelin in Theiler's virus persistence in the central nervous system.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1078801.531728 ◽

2007 ◽

Author(s):

Klaus-Armin Nave ◽

Hauke Werner

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Theiler's Virus ◽

Virus Persistence ◽

The Central Nervous System

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The Role of Neuropeptide Y and Peptide YY in the Development of Obesity via Gut-brain Axis

Current Protein and Peptide Science ◽

10.2174/1389203720666190125105401 ◽

2019 ◽

Vol 20 (7) ◽

pp. 750-758 ◽

Cited By ~ 7

Author(s):

Yi Wu ◽

Hengxun He ◽

Zhibin Cheng ◽

Yueyu Bai ◽

Xi Ma

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Neuropeptide Y ◽

Metabolic Diseases ◽

Peptide Yy ◽

Vital Role ◽

Gut Peptides ◽

Nonalcoholic Fatty Liver ◽

The Central Nervous System

Obesity is one of the main challenges of public health in the 21st century. Obesity can induce a series of chronic metabolic diseases, such as diabetes, dyslipidemia, hypertension and nonalcoholic fatty liver, which seriously affect human health. Gut-brain axis, the two-direction pathway formed between enteric nervous system and central nervous system, plays a vital role in the occurrence and development of obesity. Gastrointestinal signals are projected through the gut-brain axis to nervous system, and respond to various gastrointestinal stimulation. The central nervous system regulates visceral activity through the gut-brain axis. Brain-gut peptides have important regulatory roles in the gut-brain axis. The brain-gut peptides of the gastrointestinal system and the nervous system regulate the gastrointestinal movement, feeling, secretion, absorption and other complex functions through endocrine, neurosecretion and paracrine to secrete peptides. Both neuropeptide Y and peptide YY belong to the pancreatic polypeptide family and are important brain-gut peptides. Neuropeptide Y and peptide YY have functions that are closely related to appetite regulation and obesity formation. This review describes the role of the gutbrain axis in regulating appetite and maintaining energy balance, and the functions of brain-gut peptides neuropeptide Y and peptide YY in obesity. The relationship between NPY and PYY and the interaction between the NPY-PYY signaling with the gut microbiota are also described in this review.

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The Yin and Yang of BK Channels in Epilepsy

CNS & Neurological Disorders - Drug Targets ◽

10.2174/1871527317666180213142403 ◽

2018 ◽

Vol 17 (4) ◽

pp. 272-279 ◽

Cited By ~ 12

Author(s):

Yudan Zhu ◽

Shuzhang Zhang ◽

Yijun Feng ◽

Qian Xiao ◽

Jiwei Cheng ◽

...

Keyword(s):

Central Nervous System ◽

Nervous System ◽

Bk Channels ◽

Bk Channel ◽

Potential Shape ◽

Yin And Yang ◽

The Central Nervous System ◽

Action Potential Shape ◽

Excitability Of Neurons

Background & Objective: The large conductance calcium-activated potassium (BK) channel, extensively distributed in the central nervous system (CNS), is considered as a vital player in the pathogenesis of epilepsy, with evidence implicating derangement of K+ as well as regulating action potential shape and duration. However, unlike other channels implicated in epilepsy whose function in neurons could clearly be labeled “excitatory” or “inhibitory”, the unique physiological behavior of the BK channel allows it to both augment and decrease the excitability of neurons. Thus, the role of BK in epilepsy is controversial so far, and a growing area of intense investigation. Conclusion: Here, this review aims to highlight recent discoveries on the dichotomous role of BK channels in epilepsy, focusing on relevant BK-dependent pro- as well as antiepileptic pathways, and discuss the potential of BK specific modulators for the treatment of epilepsy.

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Neurological and mental health consequences of COVID-19: potential implications for well-being and labor force

Brain Communications ◽

10.1093/braincomms/fcab012 ◽

2021 ◽

Author(s):

I B Meier ◽

C Vieira Ligo Teixeira ◽

I Tarnanas ◽

F Mirza ◽

L Rajendran

Keyword(s):

Mental Health ◽

Central Nervous System ◽

Nervous System ◽

Cognitive Impairment ◽

Immune Cell ◽

Previous History ◽

Well Being ◽

Acute Disseminated Encephalomyelitis ◽

The Central Nervous System ◽

Neurological Protection

Abstract Recent case studies show that the SARS-CoV-2 infectious disease, COVID-19, is associated with accelerated decline of mental health, in particular, cognition in elderly individuals, but also with neurological and neuropsychiatric illness in young people. Recent studies also show a bidirectional link between COVID-19 and mental health in that people with previous history of psychiatric illness have a higher risk for contracting COVID-19 and that COVID-19 patients display a variety of psychiatric illnesses. Risk factors and the response of the central nervous system to the virus show large overlaps with pathophysiological processes associated with Alzheimer’s disease, delirium, post-operative cognitive dysfunction and acute disseminated encephalomyelitis, all characterized by cognitive impairment. These similarities lead to the hypothesis that the neurological symptoms could arise from neuroinflammation and immune cell dysfunction both in the periphery as well as in the central nervous system and the assumption that long-term consequences of COVID-19 may lead to cognitive impairment in the well-being of the patient and thus in today’s workforce, resulting in large loss of productivity. Therefore, particular attention should be paid to neurological protection during treatment and recovery of COVID-19, while cognitive consequences may require monitoring.

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