Prefrontal mRNA expression of long and short isoforms of D2 dopamine receptor: Possible role in delayed learning deficit caused by early life interleukin-1β treatment

2017 ◽  
Vol 333 ◽  
pp. 118-122 ◽  
Author(s):  
Alexander P. Schwarz ◽  
Alexander N. Trofimov ◽  
Olga E. Zubareva ◽  
Victoria I. Lioudyno ◽  
Vera V. Kosheverova ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Dopamine Receptor ◽  
Early Life ◽  
Interleukin 1Β ◽  
D2 Dopamine Receptor ◽  
Learning Deficit ◽  
Short Isoforms

Developmental prefrontal mRNA expression of D2 dopamine receptor splice variants and working memory impairments in rats after early life Interleukin-1β elevation

2018 ◽  
Vol 155 ◽  
pp. 231-238
Author(s):  
Alexander P. Schwarz ◽  
Alexander Yu. Rotov ◽  
Olga I. Chuprina ◽  
Darya U. Krytskaya ◽  
Alexander N. Trofimov ◽  
...  
Keyword(s):  
Working Memory ◽  
Mrna Expression ◽  
Dopamine Receptor ◽  
Early Life ◽  
Splice Variants ◽  
Interleukin 1Β ◽  
D2 Dopamine Receptor ◽  
Memory Impairments

scholarly journals ALTERATIONS IN THE MRNA EXPRESSION OF D2 DOPAMINE RECEPTOR SPLICE VARIANTS AS POSSIBLE MECHANISM OF PREFRONTAL DYSFUNCTION AFTER EARLY-LIFE IMMUNE CHALLENGE

2019 ◽  
Vol 19 (1S) ◽  
pp. 109-111
Author(s):  
A P Schwarz ◽  
A N Trofimov ◽  
A M Ischenko ◽  
O E Zubareva ◽  
V M Klimenko
Keyword(s):  
Prefrontal Cortex ◽  
Dopamine Receptor ◽  
Medial Prefrontal Cortex ◽  
Early Life ◽  
Splice Variants ◽  
Neuropsychiatric Symptoms ◽  
Developmental Expression ◽  
Immune Challenge ◽  
D2 Dopamine Receptor ◽  
Adult Rats

Various detrimental factors during early life may affect CNS development and increase risk of neuropsychiatric symptoms in later life. Disruption in brain dopaminergic system maturation is believed to be one of the mechanism of different neurodevelopmental disordrers. In this article we review behavioral peculiarities and changes of prefrontal D2 dopamine receptor splice variants (D2S and D2L) expression in rats after chronic experimental increase of proinflammatory cytokine interleukin(IL)-1β during 3rd week of life. Early life IL-1β treatment produce long lasting working memory deficit originating in juvenile adult animals. Elevation of IL-1β during 3rd week of life also affect developmental expression of D2 dopamine receptor mRNAs leading to increased D2S/D2L ratio in the medial prefrontal cortex of adolescent but not adult rats. Early life IL-1β treatment cancelled the learning-induced D2L mRNA downregulation during active avoidance conditioning in adult rats. Thus, dysregulation of expression of distinct D2 dopamine receptor splice variants within medial prefrontal cortex is supposed to be implicated in cognitive decline caused by early life immune challenge.

Selective increase of Nurr1 mRNA expression in mesencephalic dopaminergic neurons of D2 dopamine receptor-deficient mice

2000 ◽  
Vol 80 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Kuei Y Tseng ◽  
Christine Roubert ◽  
Louis Do ◽  
Marcelo Rubinstein ◽  
Michele A Kelly ◽  
...  
Keyword(s):  
Mrna Expression ◽  
Dopamine Receptor ◽  
Dopaminergic Neurons ◽  
D2 Dopamine Receptor ◽  
Selective Increase ◽  
Deficient Mice
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