Asymmetry of Brain Excitability: A New Biomarker that Predicts Objective and Subjective Symptoms in Multiple Sclerosis

Behavioural problems are not well recognized in multiple sclerosis (MS). In this review we aimed to evaluate the prevalence of behavioural symptoms and impairments in MS. A systematic search was carried out from MEDLINE, PsycINFO, Web of Science, CINAHL and COCHRANE. In total, 23 studies (1831 participants) were identified. Based on the literature search, behavioural symptoms and impairments are observed in MS. Aggression (23%), apathy (22%), euphoria (12%) and lack of insight (11%) were the most frequent symptoms, and adjustment disorder (17%) the most frequent impairment. Severe mental disorders are more infrequent than changes in behaviour, manner of reaction, and way of action. In conclusion the objective behavioural impairments and especially subjective symptoms are present in patients with MS. These manifestations should be taken into account in the diagnostics and treatment of the disease.

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Exercise-Induced Brain Excitability Changes in Progressive Multiple Sclerosis

Journal of Neurologic Physical Therapy ◽

10.1097/npt.0000000000000308 ◽

2020 ◽

Vol 44 (2) ◽

pp. 132-144 ◽

Cited By ~ 4

Author(s):

Arthur R. Chaves ◽

Augustine J. Devasahayam ◽

Liam P. Kelly ◽

Ryan W. Pretty ◽

Michelle Ploughman

Keyword(s):

Multiple Sclerosis ◽

Progressive Multiple Sclerosis ◽

Brain Excitability ◽

Exercise Induced

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Brain excitability changes in the relapsing and remitting phases of multiple sclerosis: a study with transcranial magnetic stimulation

Clinical Neurophysiology ◽

10.1016/j.clinph.2003.11.024 ◽

2004 ◽

Vol 115 (4) ◽

pp. 956-965 ◽

Cited By ~ 73

Author(s):

M.Donatella Caramia ◽

M.Giuseppina Palmieri ◽

M.Teresa Desiato ◽

Laura Boffa ◽

Pierluigi Galizia ◽

...

Keyword(s):

Multiple Sclerosis ◽

Transcranial Magnetic Stimulation ◽

Magnetic Stimulation ◽

Brain Excitability

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Swallowing abnormalities in multiple sclerosis: correlation between videofluoroscopy and subjective symptoms

European Radiology ◽

10.1007/s003300101086 ◽

2001 ◽

Vol 12 (4) ◽

pp. 789-792 ◽

Cited By ~ 23

Author(s):

W. Wiesner ◽

S. Wetzel ◽

L. Kappos ◽

M. Hoshi ◽

U. Witte ◽

...

Keyword(s):

Multiple Sclerosis ◽

Subjective Symptoms

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Fatigue in multiple sclerosis presenting as acute relapse: subjective and objective assessment

Multiple Sclerosis Journal ◽

10.1177/1352458507082480 ◽

2007 ◽

Vol 14 (2) ◽

pp. 274-277 ◽

Cited By ~ 24

Author(s):

Peter Flachenecker ◽

Heike Meissner

Keyword(s):

Multiple Sclerosis ◽

Time Course ◽

Objective Assessment ◽

Neuropsychological Testing ◽

High Dose ◽

Subjective Symptoms ◽

High Dose Corticosteroid ◽

Acute Relapse ◽

Dose Corticosteroid ◽

Neuropsychological Methods

We report on a patient with multiple sclerosis (MS) who presented with fatigue as the only manifestation of an acute MS relapse. Fatigue was assessed by the `Würzburg Fatigue Inventory in MS (WEIMuS)' scale and confirmed by neuropsychological testing of attention. After high-dose corticosteroid therapy, subjective symptoms were completely abolished. The improvement was corroborated by both, the WEIMuS score and neuropsychological testing. MS-related fatigue may be the only symptom of an acute MS relapse, and neuropsychological methods may be used to objectively assess and follow the time course of this common and disabling symptom. Multiple Sclerosis 2008; 14: 274—277. http://msj.sagepub.com

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