Behavioural symptoms and impairments in multiple sclerosis: a systematic review and meta-analysis

2012 ◽  
Vol 19 (1) ◽  
pp. 31-45 ◽  
Author(s):  
Eija Rosti-Otajärvi ◽  
Päivi Hämäläinen
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Mental Disorders ◽  
Literature Search ◽  
Web Of Science ◽  
Meta Analysis ◽  
Adjustment Disorder ◽  
Subjective Symptoms ◽  
Severe Mental Disorders ◽  
Behavioural Symptoms

Behavioural problems are not well recognized in multiple sclerosis (MS). In this review we aimed to evaluate the prevalence of behavioural symptoms and impairments in MS. A systematic search was carried out from MEDLINE, PsycINFO, Web of Science, CINAHL and COCHRANE. In total, 23 studies (1831 participants) were identified. Based on the literature search, behavioural symptoms and impairments are observed in MS. Aggression (23%), apathy (22%), euphoria (12%) and lack of insight (11%) were the most frequent symptoms, and adjustment disorder (17%) the most frequent impairment. Severe mental disorders are more infrequent than changes in behaviour, manner of reaction, and way of action. In conclusion the objective behavioural impairments and especially subjective symptoms are present in patients with MS. These manifestations should be taken into account in the diagnostics and treatment of the disease.

scholarly journals Prevalence of dysphagia in patients with multiple sclerosis; a systematic review and meta-analysis

2021 ◽  
Author(s):  
Omid Mirmosayyeb ◽  
Narges Ebrahimi ◽  
Arman Shekarian ◽  
Sara Bagherieh ◽  
Alireza Afshari-Safavi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Literature Search ◽  
Web Of Science ◽  
Meta Analysis ◽  
Final Analysis ◽  
Self Report ◽  
Pooled Prevalence ◽  
Screening Strategies ◽  
Conference Papers

Objectives: Dysphagia is a major comorbidity observed in patients with multiple sclerosis, yet different prevalence rates are reported for it. Therefore, we have designed this systematic review to estimate the pooled prevalence of dysphagia in patients with MS. Method: We searched PubMed, Scopus, EMBASE, Web of Science, and gray literature including references from the identified studies, reviews studies, and conference abstracts which were published up to February 2021. Articles that were relevant to our topic and could provide information regarding the prevalence of dysphagia among MS patients were included; however, articles with self-report screening strategies were excluded. Results: The literature search found 1993 articles. After eliminating duplicates, 1272 articles remained. Sixteen abstract conference papers were included for final analysis. A total of 10846 MS cases and 4913 MS patients with dysphagia included in the analysis. The pooled prevalence of dysphagia in the included studies was 45.3% (95% CI: [40.7%-50%]) Conclusion: The results of this systematic review shows that the prevalence of dysphagia in MS patients is 45% which is greatly higher compared to the general population.

scholarly journals Correlation between disability measure and Black Hole (T1 hypointense lesion) lesion load in brain magnetic resonance imaging of patients with multiple sclerosis: Protocol for a systematic review and meta-analysis

2021 ◽  
Author(s):  
Amir Valizadeh ◽  
Elham Barati ◽  
Mohammad Ali Sahraian ◽  
Mohammad Reza Fattahi ◽  
Mana Moassefi
Keyword(s):  
Magnetic Resonance Imaging ◽  
Multiple Sclerosis ◽  
Systematic Review ◽  
Web Of Science ◽  
Citation Index ◽  
Meta Analysis ◽  
Brain Magnetic Resonance Imaging ◽  
Correlation Coefficients ◽  
Resonance Imaging ◽  
Lesion Load

Abstract Rationale: As the role of neurodegeneration in the pathophysiology of multiple sclerosis (MS) has become more prominent, the formation and evolution of chronic or persistent T1-hypointense lesions (Black Holes) have been used as markers of axonal loss and neuronal destruction to measure disease activity. However, findings regarding this subject are controversial. In this study we aim to clarify the level of importance of T1 hypointense lesions for estimating the prognosis of patients.Objectives: To evaluate the correlation between T1 hypointensities (Black holes) lesion load (lesion mean volume) on brain MRI with disability level of patients with Relapsing-Remitting Multiple Sclerosis (RRMS) or Secondary-Progressive Multiple Sclerosis (SPMS).Data sources: We will search MEDLINE (through PubMed), Embase, CENTRAL, Science Citation Index – Expanded (Web of Science), and Conference Proceedings Citation Index – Science (Web of Science). We won’t consider any timeframe, language, or geographical restrictions.Methods: Standard systematic review protocol methodology is employed. Eligibility criteria is reported in line with PICOTS system. Population is limited to adult patients diagnosed with RRMS or SPMS, based on the McDonald criteria. Index (prognostic factor) of interest will be T1 hypointense (black hole) lesion mean volume (lesion load) on brain Magnetic Resonance Imaging (MRI). There will be no comparators. Outcome of interest will be the disability measure using Expanded Disability Status Scale (EDSS). For the timing domain, we will include studies only if the outcome was measured at the same time MRI was performed (or with a very close time interval between). Inpatient and outpatient settings will both be included. All included studies will be assessed for the risk of bias using a tailored version of the Quality In Prognosis Studies (QUIPS) tool. Extracted correlation coefficients will be converted to the Fisher’s z scale and a meta-analysis will be performed on the results. We will then convert back the results to correlation coefficients again for the sake of presentation. For the purpose of assessing heterogeneity we will use prediction intervals. If feasible, we will also try to perform subgroup and sensitivity analyses. We will also evaluate the publication bias using Funnel plots and assess the confidence in cumulative evidence using an adapted version of the GRADE for prognostic factor research.

scholarly journals Systematic Review and Meta-Analysis of the Occurrence of ESKAPE Bacteria Group in Dogs, and the Related Zoonotic Risk in Animal-Assisted Therapy, and in Animal-Assisted Activity in the Health Context

2020 ◽  
Vol 17 (9) ◽  
pp. 3278 ◽  
Author(s):  
Antonio Santaniello ◽  
Mario Sansone ◽  
Alessandro Fioretti ◽  
Lucia Francesca Menna
Keyword(s):  
Systematic Review ◽  
Literature Search ◽  
Animal Species ◽  
Web Of Science ◽  
Meta Analysis ◽  
Risk Of Infection ◽  
Healthcare Facilities ◽  
Rehabilitation Centers ◽  
Zoonotic Risk ◽  
Reported Data

Animal-assisted interventions are widely implemented in different contexts worldwide. Particularly, animal-assisted therapies and animal-assisted activities are often implemented in hospitals, rehabilitation centers, and other health facilities. These interventions bring several benefits to patients but can also expose them to the risk of infection with potentially zoonotic agents. The dog is the main animal species involved used in these interventions. Therefore, we aimed at collecting data regarding the occurrence of the pathogens ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp.) in dogs, in order to draft guidelines concerning the possible monitoring of dogs involved in animal-assisted therapies and animal-assisted activities in healthcare facilities. We performed a literature search using the PRISMA guidelines to examine three databases: PubMed, Web of Science, and Scopus. Out of 2604 records found, 52 papers were identified as eligible for inclusion in the review/meta-analysis. Sixteen papers reported data on E. faecium; 16 on S. aureus; nine on K. pneumoniae; four on A. baumannii; eight on P. aeruginosa; and six on Enterobacter spp. This work will contribute to increased awareness to the potential zoonotic risks posed by the involvement of dogs in animal-assisted therapies, and animal-assisted activities in healthcare facilities.

scholarly journals A Systematic Review and Meta-Analysis Examining Pneumonia-Associated Mortality in Dementia

2014 ◽  
Vol 39 (1-2) ◽  
pp. 52-67 ◽  
Author(s):  
Norine C. Foley ◽  
Rebecca H. Affoo ◽  
Ruth E. Martin
Keyword(s):  
Systematic Review ◽  
Confidence Interval ◽  
Odds Ratio ◽  
Literature Search ◽  
Causes Of Death ◽  
Web Of Science ◽  
Comparison Group ◽  
Meta Analysis ◽  
Isi Web Of Science ◽  
The Subject

Background: Although it is generally accepted that deaths associated with pneumonia are more common in patients with dementia, no comprehensive reviews on the subject have previously been published. Summary: Relevant studies were identified through a literature search of the PubMed, EMBASE, Scopus, and ISI Web of Science databases for publications up to August 2013. Studies were included if (1) a group of adult subjects with dementia and a (comparison) group composed of subjects without dementia were included, (2) the cause(s) of death was/were reported, and (3) pneumonia was identified as one of the possible causes of death. The occurrence of death due to pneumonia associated with dementia was expressed as an odds ratio (OR) with 95% confidence interval (CI). Thirteen studies were included. The odds of death resulting from pneumonia were significantly increased for persons with any form of dementia compared with those without dementia (OR = 2.22, 95% CI 1.44-3.42, p < 0.001). In a subgroup analysis, using the results from 8 studies that restricted inclusion to persons with Alzheimer's disease, the odds of death resulting from pneumonia were also significantly higher (OR = 1.70, 95% CI 1.12-2.58, p = 0.013). Key Messages: The odds of pneumonia-associated mortality were increased more than 2-fold for patients with dementia. © 2014 S. Karger AG, Basel

scholarly journals Efficacy of Topical 5% Acyclovir-1% Hydrocortisone Cream (ME-609) for Treatment of Herpes Labialis: a systematic review

2015 ◽  
Vol 87 (2 suppl) ◽  
pp. 1415-1420 ◽  
Author(s):  
MARIA INÊS DA ROSA ◽  
SUÉLI L. SOUZA ◽  
BRUNA F. DE FARIAS ◽  
PATRÍCIA D.S. PIRES ◽  
EDUARDO R. DONDOSSOLA ◽  
...  
Keyword(s):  
Systematic Review ◽  
Herpes Simplex ◽  
Literature Search ◽  
Reference Lists ◽  
Web Of Science ◽  
Meta Analysis ◽  
Grey Literature ◽  
Cochrane Central Register ◽  
Herpes Labialis ◽  
Central Register

We performed a systematic review with the objective of verifying the efficacy of topical use 5% Acyclovir-1% Hydrocortisone cream compared to the placebo group for herpes simplex labialis treatment. We performed a literature search using MEDLINE, Embase, BIOSIS, LILACS, Scopus, Grey literature, the Cochrane Central Register of Controlled Trials, the ISI Web of Science and IBECS from 1990 to June 2014. We reported the outcomes using relative risk (RR) with 95% confidence intervals. The literature search yielded 180 potentially relevant publications. Reviews of the reference lists yielded two further citations. Among these papers, two were considered eligible for inclusion in this review. Both trials included 1,213 patients. A meta-analysis of these studies showed a RR = 0.77, (95% CI 0.70-0.86; p<0.001).This result suggests that an early episodic treatment with the combination of an antiviral and a steroid is beneficial for herpes simplex labialis treatment.

Accuracy of SARS-CoV-2 Detection in Saliva for COVID-19 Diagnosis: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Dina M. Elkady ◽  
Walid Shaban Abdella ◽  
Muhamed Abdella ◽  
Abdelrahman Elsayed Kopeya ◽  
Aboalmagd Hamdallah
Keyword(s):  
Systematic Review ◽  
Literature Search ◽  
Web Of Science ◽  
Meta Analysis ◽  
High Accuracy ◽  
Oral Manifestations ◽  
Oral Diseases ◽  
Mouth Dryness ◽  
Pooled Data ◽  
Saliva Test

Context: There is an unmet clinical need to develop simple, easy, rapid, and accessible testing for the detection of SARS-CoV-2. Recent reports suggested that saliva may be a host for the virus. The existence of SARS-CoV-2 in saliva can be associated with oral manifestations in infected patients. A systematic review was conducted as well as a meta-analysis to evaluate the diagnostic accuracy of detecting SARS-CoV-2 in saliva and investigate the association between positive saliva test and oral manifestations of COVID-19. Evidence acquisition: A literature search in MEDLINE via PubMed, Scopus, Web of Science, and Cochrane was done in June 2020 and updated in February 2021 using relevant keywords. We screened studies for eligibility. The extracted data were analyzed using Meta-Disc software. Results: Eighteen studies were included. Pooled data from eligible studies showed that the sensitivity of diagnosis of SARS-CoV-2 in saliva was 0.86 (95% CI, 0.83–0.89), and the specificity was 0.98 (95% CI, 0.96–0.98). COVID-19 was associated with oral diseases as amblygeustia, dry mouth, dryness, inflammation of the mouth, and enlargement of lymph nodes in the submandibular regions. Conclusions: Our results showed that the saliva has a high accuracy in the detection of SARS-CoV-2.

Gender differences in blindness, cataract blindness and cataract surgical coverage in India: a systematic review and meta-analysis

2019 ◽  
Vol 104 (2) ◽  
pp. 220-224 ◽  
Author(s):  
Manya Prasad ◽  
Sumit Malhotra ◽  
Mani Kalaivani ◽  
Praveen Vashist ◽  
Sanjeev K Gupta
Keyword(s):  
Systematic Review ◽  
Gender Differences ◽  
Literature Search ◽  
Web Of Science ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Gender Differentials ◽  
Indian Context ◽  
Pooled Prevalence ◽  
Meta Analyses

BackgroundThe magnitude of blindness is unevenly distributed worldwide. This systematic review aimed to study gender differences in the prevalence of blindness, cataract blindness and cataract surgical coverage in India among persons aged 50 years and above.MethodsLiterature search was carried out in the Medline, Web of Science, Google Scholar, EMBASE and Trip databases. Data were abstracted and risk of bias was assessed for the selected full-text articles. Pooled prevalence, ORs and risk differences were synthesised by meta-analyses.Results22 studies were included in the systematic review. The pooled prevalence of blindness obtained for men was 4.17% and that for women was 5.68%. Women had 35% higher odds of being blind (OR 1.35, 95% CI 1.08 to 1.62) and 69% higher odds of being cataract blind (OR 1.69, 95% CI 1.44 to 1.95). Women had a 27% lower odds of getting cataract surgery (OR 0.73, 95% CI 0.45 to 1.01). In women, around 35% of the prevalence of blindness and 33% of the prevalence of cataract blindness are attributable to their gender.ConclusionMarked gender differences in blindness, cataract blindness and cataract surgical coverage were seen in India, with the odds being unfavourable for women. Interventions implemented for reduction of blindness, including cataract blindness, need to consider these gender differentials in the Indian context. Further research is needed to ascertain the reasons for these differences and devise interventions to reduce these differences in order to tackle the magnitude of avoidable blindness in India.

scholarly journals Olfactory Dysfunction in Patients with Multiple Sclerosis; A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Omid Mirmosayyeb ◽  
Narges Ebrahimi ◽  
Mahdi Barzegar ◽  
Alireza Afshari-Safavi ◽  
Sara Bagherieh ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Web Of Science ◽  
Meta Analysis ◽  
Final Analysis ◽  
Olfactory Dysfunction ◽  
Control Group ◽  
Healthy Individuals ◽  
Pooled Prevalence ◽  
Conference Papers

Objectives: Olfactory dysfunction is a major comorbidity observed in patients with multiple sclerosis, yet different prevalence rates are reported for it. Therefore, we have designed this systematic review to estimate the pooled prevalence of olfactory dysfunction in patients with MS. To our knowledge, this is the first systematic review and meta-analysis on the prevalence of olfactory dysfunction in MS patients. Method: We searched PubMed, Scopus, EMBASE, Web of Science, ProQuest, and gray literature including references from the identified studies, review studies, and conference abstracts which were published up to January 2021. Articles that were relevant to our topic and could provide information regarding the prevalence of olfactory dysfunction, or the scores of smell threshold, discrimination, or identification (TDI scores) among MS patients and healthy individuals were included; however, articles published before 1990 and after the end of 2020 were excluded. Results: The literature search found 1630 articles. After eliminating duplicates, 897 articles remained. two abstract conference papers were included for final analysis. A total of 1099 MS cases and 299 MS patients with olfactory dysfunction were included in the analysis. The pooled prevalence of olfactory dysfunction in the included studies was 27.2%. (95% CI: [19.7%, 35.4%]) Also, the overall TDI score in MS patients was lower than that in the control group (SMD=-1.00; 95% CI: [-1.44, -0.56]), and the level of Threshold (SMD= -0.47; 95% CI: [-0.75, -0.19]), Discrimination (SMD=-0.53; 95% CI: [-0.96, -0.10]), and Identification (SMD=-1.02; 95% CI: [-1.36, -0.68]) per se were lower in MS compared with control respectively. Conclusion: The results of this systematic review shows that the prevalence of olfactory dysfunction in MS patients is high and more attention needs to be drawn to this aspect of MS.

Association of MMP-2 -753C>T and MMP-9 -1562C>T Polymorphisms with Chronic/Aggressive Periodontitis Risk: A Systematic Review and Meta-Analysis

2020 ◽  
Author(s):  
Fatemeh MASHHADIABBAS ◽  
Hossein NEAMATZADEH ◽  
Elnaz FOROUGHI ◽  
Seyed Alireza DASTGHEIB ◽  
Soudabeh FARAHNAK ◽  
...  
Keyword(s):  
Systematic Review ◽  
Literature Search ◽  
Web Of Science ◽  
Meta Analysis ◽  
Aggressive Periodontitis ◽  
Case Control ◽  
Matrix Metalloproteinase 2 ◽  
Case Control Studies ◽  
Functional Polymorphisms ◽  
The Matrix

Background: Two functional polymorphisms in the matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9) genes may contribute to periodontitis pathogenesis. However, the results were inconsistent and inconclusive. Therefore, to clarify precise associations of MMP-2 -753 C>T and MMP-9 -1562C>T polymorphisms with chronic (CP) and aggressive (AgP) periodontitis, we performed a systematic review and meta-analysis. Methods: A literature search was conducted using PubMed, Google Scholar, Embase, and Web of Science databases until 5 July 2017. The data were analyzed with CMA software, and risk estimates are expressed as odds ratios (ORs) and 95% confidence intervals (95% CIs). Results: Nineteen case-control studies in ten publications with 2089 periodontitis cases and 2345 controls met the criteria. The pooled ORs indicated that MMP-2 -753C>T and MMP-9 -1562C>T polymorphisms were not significantly associated with risk of periodontitis in overall analysis. Stratified analyses by ethnicity and periodontitis type indicated that the MMP-9 -1562C>T polymorphism showed a significant association with the risk of periodontitis among Caucasians and CP/AgP subgroup, whereas MMP-2 -753C>T polymorphism was significantly associated with periodontitis risk only among Asians. Conclusion: MMP-2 -753C>T and MMP-9 -1562C>T polymorphisms may not be associated with risk of periodontitis in overall population. However, MMP-2 -753C>T and MMP-9 -1562C>T polymorphisms might have influence on the susceptibility of periodontitis by ethnicity.  

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