Exercise effects on brain and behavior in healthy mice, Alzheimer’s disease and Parkinson’s disease model—A systematic review and meta-analysis

2020 ◽  
Vol 383 ◽  
pp. 112488 ◽  
Author(s):  
Thiago Medeiros da Costa Daniele ◽  
Pedro Felipe Carvalhedo de Bruin ◽  
Robson Salviano de Matos ◽  
Gabriela Sales de Bruin ◽  
Cauby Maia Chaves ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Meta Analysis ◽  
Disease Model ◽  
Brain And Behavior ◽  
And Behavior

scholarly journals Familial Coaggregation of Alzheimer's Disease and Parkinson's Disease: Systematic Review and Meta-Analysis

2013 ◽  
Vol 42 (2) ◽  
pp. 69-80 ◽  
Author(s):  
Adina L. Feldman ◽  
Anna L.V. Johansson ◽  
Paul C. Lambert ◽  
Johanna Sieurin ◽  
Fei Yang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Meta Analysis

scholarly journals Occupational Exposures and Neurodegenerative Diseases—A Systematic Literature Review and Meta-Analyses

2019 ◽  
Vol 16 (3) ◽  
pp. 337 ◽  
Author(s):  
Lars-Gunnar Gunnarsson ◽  
Lennart Bodin
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Occupational Exposure ◽  
Neurodegenerative Diseases ◽  
Meta Analysis ◽  
Occupational Exposures ◽  
Increased Risk ◽  
Meta Analyses

Objectives: To carry out an integrated and stratified meta-analysis on occupational exposure to electromagnetic fields (EMFs), metals and pesticides and its effects on amyotrophic lateral sclerosis (ALS) and Parkinson’s and Alzheimer’s disease, and investigate the possibility of publication bias. Methods: In the current study, we updated our recently published meta-analyses on occupational exposures in relation to ALS, Alzheimer’s and Parkinson’s disease. Based on 66 original publications of good scientific epidemiological standard, according to the Meta-analysis of Observational Studies in Epidemiology (MOOSE) and the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) guidelines, we analysed subgroups by carrying out stratified meta-analyses on publication year, statistical precision of the relative risk (RR) estimates, inspection of the funnel plots and test of bias. Results: Based on 19 studies the weighted RR for occupational exposure to EMFs was 1.26 (95% confidence interval (CI) 1.07–1.50) for ALS, 1.33 (95% CI 1.07–1.64) for Alzheimer’s disease and 1.02 (95% CI 0.83–1.26) for Parkinson’s disease. Thirty-one studies concerned occupational exposure to pesticides and the weighted RR was 1.35 (95% CI 1.02–1.79) for ALS, 1.50 (95% CI 0.98–2.29) for Alzheimer’s disease and 1.66 (95% CI 1.42–1.94) for Parkinson’s disease. Finally, 14 studies concerned occupational exposure to metals and only exposure to lead (five studies) involved an elevated risk for ALS or Parkinson’s disease and the weighted RR was 1.57 (95% CI 1.11–2.20). The weighted RR for all the non-lead exposures was 0.97 (95% CI 0.88–1.06). Conclusions: Exposure to pesticides increased the risk of getting the mentioned neurodegenerative diseases by at least 50%. Exposure to lead was only studied for ALS and Parkinson’s disease and involved 50% increased risk. Occupational exposure to EMFs seemed to involve some 10% increase in risk for ALS and Alzheimer’s disease only.

Neuroprotective and preventative effects of molecular hydrogen

2020 ◽  
Vol 26 ◽  
Author(s):  
Mami Noda ◽  
Jiankang Liu ◽  
Jiangang Long
Keyword(s):  
Alzheimer’S Disease ◽  
Parkinson’S Disease ◽  
Alzheimer's Disease ◽  
Parkinson's Disease ◽  
Molecular Hydrogen ◽  
Neuronal Damage ◽  
Disease Model ◽  
Endocrine System ◽  
Hydrogen Gas ◽  
Tyrosine Kinase Receptor

: One of the beneficial effects of molecular hydrogen (H2 , hydrogen gas) is neuroprotection and prevention of neurological disorders. It is important and useful if taking H2 every day can prevent or ameliorate the progression of neurodegenerative disorders such as Parkinson’s disease or Alzheimer’s disease, both lacking specific therapeutic drugs. There are several mechanisms how H2 protects neuronal damage. Anti-oxidative, anti-inflammatory, and the regulation of endocrine system via stomach-brain connection seem to play an important role. In cellular and tissue level, H2 appears to prevent the production of reactive oxygen species (ROS), not only hydroxy radical（•OH）but also superoxide. In Parkinson’s disease model mice, chronic intake of H2 causes the release of ghrelin from the stomach. In Alzheimer’s disease model mice, sex-different neuroprotection is observed by chronic intake of H2 . In female mice, declines of estrogen and estrogen receptor- (ER) are prevented by H2 , upregulating brain-derived neurotrophic factor (BDNF) and its receptor, tyrosine kinase receptor B (TrkB). The question how drinking H2 upregulates the release of ghrelin or attenuates the decline of estrogen remains to be investigated. The mechanism how H2 modulates endocrine systems and the fundamental question what or where is the target of H2 needs to be elucidated for better understanding of the effects of H2 .

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