Decreased levels of RGS4 in the paraventricular nucleus facilitate GABAergic inhibition during the acute stress response

2016 ◽  
Vol 472 (1) ◽  
pp. 276-280 ◽  
Author(s):  
Soonwoong Jung ◽  
Hyeonwi Son ◽  
Dong Hoon Lee ◽  
Gu Seob Roh ◽  
Sang Soo Kang ◽  
...  
Keyword(s):  
Stress Response ◽  
Paraventricular Nucleus ◽  
Acute Stress ◽  
Gabaergic Inhibition ◽  
Acute Stress Response

scholarly journals The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice

2021 ◽  
Author(s):  
Alexander S. Häusl ◽  
Lea M. Brix ◽  
Jakob Hartmann ◽  
Max L. Pöhlmann ◽  
Juan-Pablo Lopez ◽  
...  
Keyword(s):  
Stress Response ◽  
Hpa Axis ◽  
Paraventricular Nucleus ◽  
Acute Stress ◽  
Negative Regulator ◽  
Neuron Activity ◽  
Cell Type ◽  
Specific Expression ◽  
Acute Stress Response ◽  
Cell Type Specific

AbstractDisturbed activation or regulation of the stress response through the hypothalamic-pituitary-adrenal (HPA) axis is a fundamental component of multiple stress-related diseases, including psychiatric, metabolic, and immune disorders. The FK506 binding protein 51 (FKBP5) is a negative regulator of the glucocorticoid receptor (GR), the main driver of HPA axis regulation, and FKBP5 polymorphisms have been repeatedly linked to stress-related disorders in humans. However, the specific role of Fkbp5 in the paraventricular nucleus of the hypothalamus (PVN) in shaping HPA axis (re)activity remains to be elucidated. We here demonstrate that the deletion of Fkbp5 in Sim1+ neurons dampens the acute stress response and increases GR sensitivity. In contrast, Fkbp5 overexpression in the PVN results in a chronic HPA axis over-activation, and a PVN-specific rescue of Fkbp5 expression in full Fkbp5 KO mice normalizes the HPA axis phenotype. Single-cell RNA sequencing revealed the cell-type-specific expression pattern of Fkbp5 in the PVN and showed that Fkbp5 expression is specifically upregulated in Crh+ neurons after stress. Finally, Crh-specific Fkbp5 overexpression alters Crh neuron activity, but only partially recapitulates the PVN-specific Fkbp5 overexpression phenotype. Together, the data establish the central and cell-type-specific importance of Fkbp5 in the PVN in shaping HPA axis regulation and the acute stress response.

scholarly journals The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus

2019 ◽  
Author(s):  
Alexander S. Häusl ◽  
Jakob Hartmann ◽  
Max L. Pöhlmann ◽  
Lea M. Brix ◽  
Juan-Pablo Lopez ◽  
...  
Keyword(s):  
Stress Response ◽  
Hpa Axis ◽  
Paraventricular Nucleus ◽  
Acute Stress ◽  
Negative Regulator ◽  
Immune Disorders ◽  
Fk506 Binding Protein ◽  
Main Driver ◽  
Acute Stress Response

Disturbed activation or regulation of the stress response through the hypothalamic-pituitary-adrenal (HPA) axis is a fundamental component of multiple stress-related diseases, including psychiatric, metabolic and immune disorders. The FK506 binding protein 51 (FKBP5) is a negative regulator of the glucocorticoid receptor (GR), a main driver of HPA axis regulation, and FKBP5 polymorphisms have been repeatedly linked to stress-related disorders in humans. However, the specific role of Fkbp5 in the paraventricular nucleus of the hypothalamus (PVN) in shaping HPA axis (re)activity remains to be elucidated. Using deletion, overexpression, and rescue of Fkbp5 exclusively in the PVN, we establish the fundamental importance of Fkbp5 in the HPA axis stress response. Furthermore, we show that Fkbp5 manipulation alters GR activation and elucidate the cellular complexity in the PVN, in which Fkbp5 operates.

Monitoring the acute stress response and its aftermath using combined fMRI/endocrine measurements

2013 ◽  
Vol 46 (06) ◽  
Author(s):  
I Elbau ◽  
SA Kiem ◽  
A Prosser ◽  
I Eidner ◽  
M Czisch ◽  
...  
Keyword(s):  
Stress Response ◽  
Acute Stress ◽  
Acute Stress Response

Acute stress response modified by modest inhibition of growth hormone axis: A potential machinery of the anti-aging effect of calorie restriction

2011 ◽  
Vol 132 (3) ◽  
pp. 103-109 ◽  
Author(s):  
Toshimitsu Komatsu ◽  
Lucas S. Trindade ◽  
Takuya Chiba ◽  
Hiroko Hayashi ◽  
Tomoko Henmi ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Stress Response ◽  
Calorie Restriction ◽  
Acute Stress ◽  
Aging Effect ◽  
Inhibition Of Growth ◽  
Acute Stress Response

Effects of acetylsalicylic acid treatment on thyroid hormones, prolactins, and the stress response of tilapia (Oreochromis mossambicus)

2003 ◽  
Vol 285 (5) ◽  
pp. R1098-R1106 ◽  
Author(s):  
Rogier D. van Anholt ◽  
Tom Spanings ◽  
William Koven ◽  
Sjoerd E. Wendelaar Bonga
Keyword(s):  
Stress Response ◽  
Acetylsalicylic Acid ◽  
Acute Stress ◽  
Oreochromis Mossambicus ◽  
Control Fish ◽  
Mild Stress ◽  
Cox Inhibitor ◽  
Basal Plasma ◽  
Acute Stress Response

The cyclooxygenase (COX) pathway converts arachidonic acid (ArA) into prostaglandins (PGs), which interact with the stress response in mammals and possibly in fish as well. Acetylsalicylic acid (ASA) is a COX inhibitor and was used to characterize the effects of PGs on the release of several hormones and the stress response of tilapia ( Oreochromis mossambicus). Plasma PGE2 was significantly reduced at 100 mg ASA/kg body wt, and both basal PGE2 and cortisol levels correlated negatively with plasma salicylate. Basal plasma 3,5,3′-triiodothyronine (T3) was reduced by ASA treatment, whereas prolactin (PRL)188 increased at 100 mg ASA/kg body wt. ASA depressed the cortisol response to the mild stress of 5 min of net confinement. As expected, glucose and lactate were elevated in the stressed control fish, but the responses were blunted by ASA treatment. Gill Na+-K+-ATPase activity was not affected by ASA. Plasma osmolarity increased after confinement in all treatments, whereas sodium only increased at the high ASA dose. This is the first time ASA has been administered to fish in vivo, and the altered hormone release and the inhibition of the acute stress response indicated the involvement of PGs in these processes.

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