Deregulation of WNT2/FZD3/β-catenin pathway compromises the estrogen synthesis in cumulus cells from patients with polycystic ovary syndrome

2017 ◽  
Vol 493 (1) ◽  
pp. 847-854 ◽  
Author(s):  
Gu-yuan Qiao ◽  
Bing-wei Dong ◽  
Chao-juan Zhu ◽  
Chang-you Yan ◽  
Bi-liang Chen
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cumulus Cells ◽  
Ovary Syndrome ◽  
Estrogen Synthesis

Novel circular RNA expression in the cumulus cells of patients with polycystic ovary syndrome

2019 ◽  
Vol 299 (6) ◽  
pp. 1715-1725 ◽  
Author(s):  
Zhi Ma ◽  
Huishan Zhao ◽  
Yan Zhang ◽  
Xiaoyan Liu ◽  
Cuifang Hao
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovary ◽  
Cumulus Cells ◽  
Circular Rna ◽  
Rna Expression ◽  
Ovary Syndrome

scholarly journals TNFR1 is Upregulated and Mediates Apoptosis in Cumulus Cells of Women With Polycystic Ovarian Syndrome

2021 ◽  
Author(s):  
Yaping Jiang ◽  
Rui Jiang ◽  
Peng Zhang ◽  
qiong Yu ◽  
Hongping Ba ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Signaling Pathway ◽  
Granulosa Cells ◽  
Follicular Fluid ◽  
Polycystic Ovary ◽  
Cumulus Cells ◽  
Control Group ◽  
Ovary Syndrome ◽  
Tnf Α ◽  
Pcos Group

Abstract Purpose To investigate the changes of human granulosa cell, TNFR1, TNFR2 and their downstream molecules in patients with polycystic ovary syndrome (PCOS) and the control group. Methods We recruited infertile women with polycystic ovary syndrome (n = 30) and compared them with infertility due to fallopian tube obstruction(n = 30, control group). The ovaries were stimulated with GnRH agonists and gonadotropins. Follicular fluid from large follicles ([14 mm]) was pooled and granulosa cells (GCs) were separated by a cellular filter. The TNF-α level of follicular fluid was measured by ELISA. TUNEL assay were used to detect the apoptosis of purified GCs. Real-time PCR and Western blotting were used to detect the expression of TNF-related signaling molecules in GCs. Results The rate of high quality embryos in the PCOS group was lower than that in the control group. There were higher percentages of apoptosis in GCs of PCOS patients than in the control group. TNF-α is upregulated in follicular fluid of PCOS patients. TNFR1 and caspase-3 mRNA level were signifificantly higher in PCOS group than in the control group. TNF-α-mediated apoptosis of PCOS granulosa cells was mainly dependent on TNFR1.The TNF-α/TNFR1 signaling pathway mediates apoptosis rather than survival in cumulus cells of PCOS patients. Conclusions TNF-α expression was upregulated in follicular fluid of PCOS patients, and TNFR1 overexpression in female granulosa cells of PCOS was associated with higher levels of apoptosis in these cells, suggesting that the TNF-α/TNFR1 signaling pathway may be a candidate for higher apoptosis in female granulosa cells of PCOS.

scholarly journals Single-cell expression analysis of BMP15 and GDF9 in mature oocytes and BMPR2 in cumulus cells of women with polycystic ovary syndrome undergoing controlled ovarian hyperstimulation

2012 ◽  
Vol 29 (10) ◽  
pp. 1057-1065 ◽  
Author(s):  
Luciana Ochuiuto Teixeira de Resende ◽  
Alessandra Aparecida Vireque ◽  
Laura Ferreira Santana ◽  
Daniel Antunes Moreno ◽  
Ana Carolina Japur de Sá Rosa e Silva ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Single Cell ◽  
Expression Analysis ◽  
Polycystic Ovary ◽  
Cumulus Cells ◽  
Controlled Ovarian Hyperstimulation ◽  
Ovarian Hyperstimulation ◽  
Ovary Syndrome ◽  
Cell Expression

scholarly journals Overexpression of ribosomal RNA in cumulus cells of patients with polycystic ovary syndrome

2012 ◽  
Vol 29 (10) ◽  
pp. 1141-1145 ◽  
Author(s):  
Mikhail Polzikov ◽  
Sergey Yakovenko ◽  
Julia Voznesenskaya ◽  
Maria Troshina ◽  
Olga Zatsepina
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Ribosomal Rna ◽  
Polycystic Ovary ◽  
Cumulus Cells ◽  
Ovary Syndrome

Apoptotic biomarkers in cumulus cells in relation to embryo quality in polycystic ovary syndrome

2017 ◽  
Vol 296 (6) ◽  
pp. 1219-1227 ◽  
Author(s):  
Ensieh Salehi ◽  
Reza Aflatoonian ◽  
Ashraf Moeini ◽  
Nazila Yamini ◽  
Ebrahim Asadi ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Embryo Quality ◽  
Polycystic Ovary ◽  
Cumulus Cells ◽  
Ovary Syndrome
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