Mesenchymal stem cells derived exosomal miR-323-3p promotes proliferation and inhibits apoptosis of cumulus cells in polycystic ovary syndrome (PCOS)

Mesenchymal stem cells (MSCs) are highly capable of self-renewal and differentiation. They can be isolated from a variety of sources such as adipose tissue, bone marrow, umbilical cord, tooth pulp and can be cultured under in vitro conditions. MSCs have anti-inflammatory, anti-apoptotic, angiogenic, immunomodulatory and many more therapeutic effects due to the effects of paracrine factors they secrete. Today, mesenchymal stem cells are used for treatment in more than twenty diseases, from spinal cord injuries to diabetes. However, there is little mention in the literature of the use of these cells in female reproductive system diseases. In this review, a limited number of clinical and experimental studies on the use of mesenchymal stem cells in the treatment of polycystic ovary syndrome, which is very common in women, were examined and analyzed.

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Towards cell therapy of polycystic ovary syndrome (PCOS): human mesenchymal stem cells secretome inhibits androgen production by pcos theca cells

Cytotherapy ◽

10.1016/j.jcyt.2019.03.493 ◽

2019 ◽

Vol 21 (5) ◽

pp. S81

Author(s):

R. Chugh ◽

D. Ashour ◽

N. Garcia ◽

H. Park ◽

H. Takala ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Polycystic Ovary Syndrome ◽

Cell Therapy ◽

Polycystic Ovary ◽

Human Mesenchymal Stem Cells ◽

Ovary Syndrome ◽

Theca Cells

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towards stem cell therapy of polycystic ovary syndrome (PCOS): therapeutic effect of human mesenchymal stem cells transplantation in pcos mouse model by regulating ovarian vascularization

Cytotherapy ◽

10.1016/j.jcyt.2019.03.484 ◽

2019 ◽

Vol 21 (5) ◽

pp. S78

Author(s):

H. Park ◽

D. Ashour ◽

A. Elsharoud ◽

R. Chugh ◽

A. Al-Hendy ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Stem Cell ◽

Polycystic Ovary Syndrome ◽

Mouse Model ◽

Cell Therapy ◽

Polycystic Ovary ◽

Human Mesenchymal Stem Cells ◽

Ovary Syndrome ◽

Stem Cells Transplantation

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Towards stem cell therapy of polycystic ovary syndrome (PCOS): human mesenchymal stem cells engrafment in letrozole-induced PCOS murine model

Fertility and Sterility ◽

10.1016/j.fertnstert.2017.07.743 ◽

2017 ◽

Vol 108 (3) ◽

pp. e247-e248

Author(s):

P.I. Igboeli ◽

A. El Andaloussi ◽

M.K. Omar ◽

M. Ali ◽

A. Laknaur ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Stem Cell ◽

Polycystic Ovary Syndrome ◽

Cell Therapy ◽

Stem Cell Therapy ◽

Murine Model ◽

Polycystic Ovary ◽

Human Mesenchymal Stem Cells ◽

Ovary Syndrome

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Human Granulosa Cells—Stemness Properties, Molecular Cross-Talk and Follicular Angiogenesis

Cells ◽

10.3390/cells10061396 ◽

2021 ◽

Vol 10 (6) ◽

pp. 1396

Author(s):

Claudia Dompe ◽

Magdalena Kulus ◽

Katarzyna Stefańska ◽

Wiesława Kranc ◽

Błażej Chermuła ◽

...

Keyword(s):

Stem Cells ◽

Granulosa Cells ◽

Polycystic Ovary ◽

Ovarian Follicle ◽

Cumulus Cells ◽

Ovary Syndrome ◽

Different Types ◽

Metabolite Exchange ◽

Reproductive Techniques ◽

New Strategies

The ovarian follicle is the basic functional unit of the ovary, comprising theca cells and granulosa cells (GCs). Two different types of GCs, mural GCs and cumulus cells (CCs), serve different functions during folliculogenesis. Mural GCs produce oestrogen during the follicular phase and progesterone after ovulation, while CCs surround the oocyte tightly and form the cumulus oophurus and corona radiata inner cell layer. CCs are also engaged in bi-directional metabolite exchange with the oocyte, as they form gap-junctions, which are crucial for both the oocyte’s proper maturation and GC proliferation. However, the function of both GCs and CCs is dependent on proper follicular angiogenesis. Aside from participating in complex molecular interplay with the oocyte, the ovarian follicular cells exhibit stem-like properties, characteristic of mesenchymal stem cells (MSCs). Both GCs and CCs remain under the influence of various miRNAs, and some of them may contribute to polycystic ovary syndrome (PCOS) or premature ovarian insufficiency (POI) occurrence. Considering increasing female fertility problems worldwide, it is of interest to develop new strategies enhancing assisted reproductive techniques. Therefore, it is important to carefully consider GCs as ovarian stem cells in terms of the cellular features and molecular pathways involved in their development and interactions as well as outline their possible application in translational medicine.

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