Protective role of mesenchymal stem cells transfected with miRNA-378a-5p in phosgene inhalation lung injury

2020 ◽  
Vol 530 (1) ◽  
pp. 189-195
Author(s):  
Yubei Qu ◽  
Lin Zhang ◽  
Daikun He ◽  
Ning Xu ◽  
Yuedong Tang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Lung Injury ◽  
Protective Role

Su1793 The Protective Role of Human Mesenchymal Stem Cells in Acute Pancreatitis in Mice

2013 ◽  
Vol 144 (5) ◽  
pp. S-478
Author(s):  
Michael Gonzales ◽  
Xuxia Gao ◽  
Yanna Cao ◽  
Hasen Xue ◽  
Judith Aronson ◽  
...  
Keyword(s):  
Stem Cells ◽  
Acute Pancreatitis ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Protective Role

scholarly journals Adipogenic impairment of adipose tissue-derived mesenchymal stem cells in subjects with metabolic syndrome: possible protective role of FGF2

2016 ◽  
pp. jc.2016-2256 ◽  
Author(s):  
WILFREDO OLIVA-OLIVERA ◽  
LETICIA COÍN-Aragüez ◽  
SAID LHAMYANI ◽  
MERCEDES CLEMENTE-POSTIGO ◽  
JUAN ALCAIDE TORRES ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Adipose Tissue ◽  
Protective Role

The Role Of Mesenchymal Stem Cells During Repair From Ventilator Induced Lung Injury

2011 ◽  
Author(s):  
Gerard F. Curley ◽  
Mairead Hayes ◽  
Maya Contreras ◽  
Brendan D. Higgins ◽  
Daniel P. O'Toole ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Lung Injury ◽  
Ventilator Induced Lung Injury

scholarly journals The effect of low dose statin combined with grapefruit on muscle structure and the possible protective role of mesenchymal stem cells

QJM ◽  
2018 ◽  
Vol 111 (suppl_1) ◽  
Author(s):  
W Baher ◽  
A A Abo Zeid ◽  
B Mohamed Fahmy ◽  
A Mohamed Hashem ◽  
R Ashraf Sakr ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Low Dose ◽  
Protective Role ◽  
Muscle Structure

scholarly journals The Vascular Endothelial Growth Factors-Expressing Character of Mesenchymal Stem Cells Plays a Positive Role in Treatment of Acute Lung InjuryIn Vivo

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Yi Yang ◽  
Shuling Hu ◽  
Xiuping Xu ◽  
Jinze Li ◽  
Airan Liu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Lung Injury ◽  
Therapeutic Effects ◽  
Vascular Endothelial ◽  
Positive Role ◽  
Lung Permeability ◽  
Injured Lung ◽  
Endothelial Growth Factor

Recently, mesenchymal stem cells (MSC) have been proved to be beneficial in acute respiratory distress syndrome (ARDS). Vascular endothelial growth factor (VEGF) is an important angiogenesis factor that MSC release. However, the precise role of VEGF-expressing character of MSC in the MSC treatment for ARDS remains obscure. Here, we firstly knocked down the gene VEGF in MSC (MSC-ShVEGF) with lentiviral transduction. Then we injected the MSC-ShVEGF to rats with lipopolysaccharide-induced acute lung injury (ALI) via the tail vein. Data showed that MSC transplantation significantly increased VEGF levels in the lung, reduced lung permeability, protected lung endothelium from apoptosis, facilitated VE-cadherin recovery, controlled inflammation, and attenuated lung injury. However, VEGF gene knockdown in MSC led to relatively insufficient VEGF expression in the injured lung and significantly diminished the therapeutic effects of MSC on ALI, suggesting an important role of VEGF-expressing behavior of MSC in the maintenance of VEGF in the lung and the MSC treatment for ALI. Hence, we conclude that MSC restores the lung permeability and attenuates lung injury in rats with ALI in part by maintaining a “sufficient” VEGF level in the lung and the VEGF-expressing character of MSC plays a positive role in the therapeutic effects of MSC on ARDS.

scholarly journals Anti-inflammatory Role of Mesenchymal Stem Cells in an Acute Lung Injury Mouse Model

2018 ◽  
Vol 33 (3) ◽  
pp. 154-161 ◽  
Author(s):  
Jin Won Huh ◽  
Won Young Kim ◽  
Yun Young Park ◽  
Chae-Man Lim ◽  
Younsuck Koh ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Mouse Model ◽  
Anti Inflammatory

The possible therapeutic role of mesenchymal stem cells in amiodarone-induced lung injury in adult male albino rats

2018 ◽  
Vol 46 (3) ◽  
pp. 172
Author(s):  
MaramM.M Ghabrial ◽  
MaysaF.M Salem ◽  
AmlM.A.A El Ela ◽  
SafwatA.A El Deeb
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Lung Injury ◽  
Adult Male ◽  
Albino Rats ◽  
Therapeutic Role
Sign in / Sign up

Export Citation Format

Share Document