Sequence and structural analysis of COVID-19 E and M protein with MERS virus E and M protein—A comparative study

A hallmark feature of severe Group A Streptococcus pyogenes (GAS) infection is dysregulated hemostasis. Hemostasis is the primary pathway for regulating blood flow through events that contribute towards clot formation and its dissolution. However, a number of studies have identified components of hemostasis in regulating survival and dissemination of GAS. Several proteins have been identified on the surface of GAS and they serve to either facilitate invasion to host distal sites or regulate inflammatory responses to the pathogen. GAS M-protein, a surface-exposed virulence factor, appears to be a major target for interactions with host hemostasis proteins. These interactions mediate biochemical events both on the surface of GAS and in the solution when M-protein is released into the surrounding environment through shedding or regulated proteolytic processes that dictate the fate of this pathogen. A thorough understanding of the mechanisms associated with these interactions could lead to novel approaches for altering the course of GAS pathogenicity.

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Structure and Expression of the Gene Encoding Murine M-Protein, a Sarcomere-Specific Member of the Immunoglobulin Superfamily

Genomics ◽

10.1006/geno.1998.5220 ◽

1998 ◽

Vol 49 (1) ◽

pp. 83-95 ◽

Cited By ~ 14

Author(s):

Frank Steiner ◽

Klaus Weber ◽

Dieter O. Fürst

Keyword(s):

Protein A ◽

M Protein ◽

Immunoglobulin Superfamily ◽

Gene Encoding

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Raised ?2-Microglobulin as a Surrogate Marker in Non-Secretory Multiple Myeloma

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v16i1.31146 ◽

2017 ◽

Vol 16 (1) ◽

pp. 142-145

Author(s):

Bimal K Agrawal ◽

Anshul Sehgal ◽

Vikas Deswal ◽

Prem Singh ◽

Usha Agrawal

Keyword(s):

Multiple Myeloma ◽

Bone Marrow ◽

Rare Case ◽

Plasma Cells ◽

Medical Science ◽

Protein A ◽

Surrogate Marker ◽

M Protein ◽

Review Of Literature ◽

Lytic Lesions

Multiple myeloma is a neoplasm of plasma cells in the bone marrow. It is characterised by lytic lesions in the bones, marrow plasmacytosis and presence of M protein in serum and/or urine. Serum ?2 microglobulin is also raised and can be used for classification and prognostication of the disease. In the absence of M protein, the disease is known as non-secretory myeloma. It is proposed that raised ?2 microglobulin can be used for diagnosis and therapeutic guidance in the absence of M protein. A rare case of nonsecretory myeloma with neurocognitive impairment along with review of literature is being presented. The patient had multiple lytic lesions in bones with marked increase in plasma cells in bone marrow. M protein was not detectable in serum or urine but serum ?2 microglobulin was much elevated.Bangladesh Journal of Medical Science Vol.16(1) 2017 p.142-145

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MANIFESTASI HEROISME DALAM TRADISI JEPANG DAN JAWA Persamaan dan Perbedaan Dongeng Momotarō dan Epos Bharatayuda

IZUMI ◽

10.14710/izumi.3.1.54-68 ◽

2014 ◽

Vol 3 (1) ◽

pp. 54

Author(s):

Fajria Noviana

Keyword(s):

Structural Analysis ◽

Comparative Study ◽

Key Words ◽

Binary Opposition ◽

Literary Works ◽

Group 3

Abstract This comparative study was conducted to find out how heroism in Japanese and Javanese traditions is manifested into two literary works representing those traditions: Momotarō and Bharatayuda. This study is also aimed to find out the similarities of heroism manifestation in the two traditions. The reason for conducting this study is from the assumption that heroism is a universal concept. Therefore, such heroisms have similarities although they may come from different traditional backgrounds. Structural analysis and binary opposition were used in this study. The structural analysis was used to obtain the data on traditional background of the areas and the actions done by the main characters, while binary opposition was used to obtain the data on the main characters’ heroic actions which were then concluded as the heroic manifestation. The result shows that the heroismmanifestation in Japanese and Javanese traditions has the following things in common: 1) conquering enemies, 2) protecting the members of the group, 3) keeping promise, 4) recompense, and 5) acting ethically. The result of this study can also prove the truth of the assumption. Key words: heroism, heroic actions, Japanese and Javanese traditions

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