scholarly journals Multiple stimuli-responsive nanosystem for potent, ROS-amplifying, chemo-sonodynamic antitumor therapy

Author(s):  
JunJie Tang ◽  
Xiaoge Zhang ◽  
Lili Cheng ◽  
Yadong Liu ◽  
You Chen ◽  
...  
2020 ◽  
Vol 7 (6) ◽  
pp. 1903243 ◽  
Author(s):  
Hao Cai ◽  
Xinghang Dai ◽  
Xiaoming Wang ◽  
Ping Tan ◽  
Lei Gu ◽  
...  

2021 ◽  
Vol 11 (20) ◽  
pp. 9541
Author(s):  
Zhichu Xiang ◽  
Mouquan Liu ◽  
Jun Song

Biocompatible nanosystems based on polymeric materials are promising drug delivery nanocarrier candidates for antitumor therapy. However, the efficacy is unsatisfying due to nonspecific accumulation and drug release of the nanoparticles in normal tissue. Recently, the nanosystems that can be triggered by tumor-specific stimuli have drawn great interest for drug delivery applications due to their controllable drug release properties. In this review, various polymers and external stimuli that can be employed to develop stimuli-responsive polymeric nanosystems are discussed, and finally, we delineate the challenges in designing this kind of Nanomedicine to improve the therapeutic efficacy.


2020 ◽  
Vol 582 ◽  
pp. 119330 ◽  
Author(s):  
Kishwor Poudel ◽  
Milan Gautam ◽  
Srijan Maharjan ◽  
Jee-Heon Jeong ◽  
Han-Gon Choi ◽  
...  

Pharmaceutics ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 630 ◽  
Author(s):  
Son H. Pham ◽  
Yonghyun Choi ◽  
Jonghoon Choi

The new era of nanotechnology has produced advanced nanomaterials applicable to various fields of medicine, including diagnostic bio-imaging, chemotherapy, targeted drug delivery, and biosensors. Various materials are formed into nanoparticles, such as gold nanomaterials, carbon quantum dots, and liposomes. The nanomaterials have been functionalized and widely used because they are biocompatible and easy to design and prepare. This review mainly focuses on nanomaterials responsive to the external stimuli used in drug-delivery systems. To overcome the drawbacks of conventional therapeutics to a tumor, the dual- and multi-responsive behaviors of nanoparticles have been harnessed to improve efficiency from a drug delivery point of view. Issues and future research related to these nanomaterial-based stimuli sensitivities and the scope of stimuli-responsive systems for nanomedicine applications are discussed.


2019 ◽  
Vol 5 (9) ◽  
pp. 4474-4484 ◽  
Author(s):  
Xuwu Zhang ◽  
Tian Yin ◽  
Shuai Wang ◽  
Zining Hao ◽  
Yaqian He ◽  
...  

Nanoscale ◽  
2018 ◽  
Vol 10 (28) ◽  
pp. 13737-13750 ◽  
Author(s):  
Junjie Liu ◽  
Xingming Guo ◽  
Zhong Luo ◽  
Jixi Zhang ◽  
Menghuan Li ◽  
...  

Poor drug delivery to solid tumors remains a great challenge for effective antitumor therapy.


RSC Advances ◽  
2019 ◽  
Vol 9 (16) ◽  
pp. 9260-9269 ◽  
Author(s):  
Bin Yang ◽  
Kaiyuan Wang ◽  
Dong Zhang ◽  
Bin Ji ◽  
Dongyang Zhao ◽  
...  

Development of smart stimuli-responsive prodrug nanomaterials for fast drug release and efficient antitumor therapy has attracted great attention in recent years.


2020 ◽  
Vol 11 (24) ◽  
pp. 3940-3950 ◽  
Author(s):  
Patrick Verkoyen ◽  
Holger Frey

Amino-functional polyethers have emerged as a new class of “smart”, i.e. pH- and thermoresponsive materials. This review article summarizes the synthesis and applications of these materials, obtained from ring-opening of suitable epoxide monomers.


Author(s):  
Khodadad Mostakim ◽  
Nahid Imtiaz Masuk ◽  
Md. Rakib Hasan ◽  
Md. Shafikul Islam

The advancement in 3D printing has led to the rapid growth of 4D printing technology. Adding time, as the fourth dimension, this technology ushered the potential of a massive evolution in fields of biomedical technologies, space applications, deployable structures, manufacturing industries, and so forth. This technology performs ingenious design, using smart materials to create advanced forms of the 3-D printed specimen. Improvements in Computer-aided design, additive manufacturing process, and material science engineering have ultimately favored the growth of 4-D printing innovation and revealed an effective method to gather complex 3-D structures. Contrast to all these developments, novel material is still a challenging sector. However, this short review illustrates the basic of 4D printing, summarizes the stimuli responsive materials properties, which have prominent role in the field of 4D technology. In addition, the practical applications are depicted and the potential prospect of this technology is put forward.


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