Molecular mechanisms of TNF-α-induced apoptosis in aging human T cell subsets

2005 ◽  
Vol 37 (5) ◽  
pp. 1034-1042 ◽  
Author(s):  
Sudhir Gupta ◽  
Sastry Gollapudi
Keyword(s):  
T Cell ◽  
Molecular Mechanisms ◽  
T Cell Subsets ◽  
Human T Cell ◽  
Tnf Α ◽  
Induced Apoptosis

scholarly journals Transcription factor GATA-1 potently represses the expression of the HIV-1 coreceptor CCR5 in human T cells and dendritic cells

Blood ◽  
2005 ◽  
Vol 106 (10) ◽  
pp. 3440-3448 ◽  
Author(s):  
Mark S. Sundrud ◽  
Scott E. VanCompernolle ◽  
Karla A. Eger ◽  
Tullia C. Bruno ◽  
Arun Subramaniam ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Chemokine Receptor ◽  
Molecular Mechanisms ◽  
T Cell Subsets ◽  
Critical Determinant ◽  
Human T Cell ◽  
Human T Cells ◽  
Hiv 1

AbstractCC chemokine receptor 5 (CCR5) is the major HIV-1 coreceptor and its expression levels are a critical determinant of HIV-1 infection. However, the molecular mechanisms of CCR5 regulation in primary targets of HIV-1 remain unknown. Despite binding to conserved DNA elements, we show that the transcription factors GATA binding protein 1 (GATA-1) and GATA-3 differentially suppress the expression of CCR5 in stem-cell–derived dendritic cells and primary human T-cell subsets. In addition, GATA-1 expression was also more potent than GATA-3 in suppressing T helper 1 (Th1)–associated genes, interferon-γ (IFNγ), and CXC chemokine receptor-3 (CXCR3). GATA-1, but not GATA-3, potently suppressed CCR5 transcription, thereby rendering human T cells resistant to CCR5-tropic HIV-1 infection. However, GATA-1 could also serve as a surrogate for GATA-3 in its canonic role of programming Th2 gene expression. These findings provide insight into GATA-3–mediated gene regulation during T-cell differentiation. Importantly, decoding the mechanisms of GATA-1–mediated repression of CCR5 may offer an opportunity to develop novel approaches to inhibit CCR5 expression in T cells.

scholarly journals Dipeptidyl-Amino-Peptidase IV (DAP IV) Activity in Human T-Cell Subsets

1984 ◽  
Vol 72 (3) ◽  
pp. 213-214 ◽  
Author(s):  
J. Dufer ◽  
J. Bernard
Keyword(s):  
T Cell ◽  
T Cell Subsets ◽  
Human T Cell

Effect of L-Carnitine on Fas-Induced Apoptosis and Sphingomyelinase Activity in Human T Cell Lines

1997 ◽  
pp. 105-117 ◽  
Author(s):  
Edoardo Alesse ◽  
Luisa Di Marzio ◽  
Paola Roncaioli ◽  
Francesca Zazzeroni ◽  
Adriano Angelucci ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lines ◽  
Human T Cell ◽  
Induced Apoptosis ◽  
T Cell Lines

scholarly journals Gamma (immune) interferon production by leukocytes from a patient with a TG cell proliferative disease

Blood ◽  
1982 ◽  
Vol 59 (1) ◽  
pp. 198-201 ◽  
Author(s):  
JJ Hooks ◽  
BF Haynes ◽  
B Detrick-Hooks ◽  
LF Diehl ◽  
TL Gerrard ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Activity ◽  
Morphological Characteristics ◽  
Lymphocytic Leukemia ◽  
Lymphoid Cells ◽  
T Cell Subsets ◽  
Ifn Gamma ◽  
Killer Activity ◽  
Human T Cell

Abstract We report a patient with a disease characterized by proliferation of T cells with Fc receptors for IgG (TG). However, unlike lymphoid cells from normal individuals or from patients with other lymphoid malignancies, the patient's lymphocytes spontaneously produced gamma interferon (IFN-gamma) in vitro. The peripheral lymphocytes consisted of 95% TG cells, which exhibited the morphological characteristics of T- cell chronic lymphocytic leukemia (CLL) and were normal on cytochemical and chromosome analysis. The majority of TG cells were OKT3+, OKT8+, and OKT4-, 3A1-. These cells failed to express suppressor cell activity and displayed depressed levels of natural killer activity, but mediated antibody-dependent cell-mediated cytotoxicity. The spontaneous production of IFN-gamma by human peripheral lymphoid cells as demonstrated in this study may serve as a probe for studying the relationship between IFN-gamma and the proliferation of human T-cell subsets.

scholarly journals Sensitive Gene Expression Profiling of Human T Cell Subsets Reveals Parallel Post-Thymic Differentiation for CD4+ and CD8+ Lineages

2007 ◽  
Vol 179 (11) ◽  
pp. 7406-7414 ◽  
Author(s):  
Victor Appay ◽  
Andreas Bosio ◽  
Stefanie Lokan ◽  
Yvonne Wiencek ◽  
Christian Biervert ◽  
...  
Keyword(s):  
Gene Expression ◽  
T Cell ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
T Cell Subsets ◽  
Human T Cell

scholarly journals T-cell-subset characterization of human T-CLL

Blood ◽  
1979 ◽  
Vol 53 (6) ◽  
pp. 1066-1075 ◽  
Author(s):  
EL Reinherz ◽  
LM Nadler ◽  
DS Rosenthal ◽  
WC Moloney ◽  
SF Schlossman
Keyword(s):  
T Cells ◽  
T Cell ◽  
Tumor Cells ◽  
Peripheral Blood ◽  
Lymphoblastic Leukemia ◽  
Cell Subset ◽  
T Cell Subsets ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Human T Cell ◽  
Malignant T Cells

Abstract Circulating peripheral blood tumor cells in four cases of chronic lymphoproliferative disease were immunologically characterized. By the use of T-cell-specific heteroantisera and indirect immunofluorescence, all were shown to involve proliferation of malignant T cells. Three cases demonstrated morphologic and clinical features consistent with chronic lymphocytic leukemia (CLL), and one case presented as a lymphosarcoma cell leukemia. Antisera specific for normal human T-cell subsets defined the malignant T cells in each case as arising from the TH2--subset. This subset normally constitutes approximately 80% of human peripheral blood T cells. Terminal deoxynucleotidyl transferase (TdT) was not detected in any of the T-cell CLL cases, thus supporting the notion that T-cell CLL represents a malignancy of a mature phenotype. The one patient with lymphosarcoma whose tumor cells were TdT-positive subsequently developed T-cell acute lymphoblastic leukemia (ALL). Moreover, la-like antigen (p23,30) was detected on two of these tumor cell populations. In addition, it was shown that not all tumor cells were E-rosette-positive, since only cells from 3 of 4 patients were capable of forming spontaneous rosettes. These findings demonstrate that heteroantisera can provide an additional important tool for dissecting the heterogeneity of T-cell leukemias and for relating them to more differentiated normal T cells.

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