scholarly journals Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin

2016 ◽  
Vol 81 ◽  
pp. 254-270 ◽  
Author(s):  
Saverio Francesco Retta ◽  
Angela J. Glading
Keyword(s):  
Oxidative Stress ◽  
Cavernous Malformation ◽  
Cerebral Cavernous Malformation ◽  
Disease Pathogenesis ◽  
Two Sides

scholarly journals Oxidative Stress and Hypoxia Contribute to Alzheimer's Disease Pathogenesis: Two Sides of the Same Coin

2009 ◽  
Vol 9 ◽  
pp. 781-791 ◽  
Author(s):  
Michela Guglielmotto ◽  
Elena Tamagno ◽  
Oliviero Danni
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebral Hypoperfusion ◽  
Oxygen Species ◽  
Disease Pathogenesis ◽  
App Processing ◽  
Secretase Activity ◽  
Two Sides

While it is well established that stroke and cerebral hypoperfusion are risk factors for Alzheimer's disease (AD), the molecular link between ischemia/hypoxia and amyloid precursor protein (APP) processing has only been recently established. Here we review the role of the release of reactive oxygen species (ROS) by the mitochondrial electron chain in response to hypoxia, providing evidence that hypoxia fosters the amyloidogenic APP processing through a biphasic mechanism that up-regulates β-secretase activity, which involves an early release of ROS and an activation of HIF-1α.

scholarly journals Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation

2020 ◽  
Vol 21 (2) ◽  
pp. 675 ◽  
Author(s):  
Shu Wei ◽  
Ye Li ◽  
Sean P. Polster ◽  
Christopher R. Weber ◽  
Issam A. Awad ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Barrier Function ◽  
Somatic Mutations ◽  
Cavernous Malformation ◽  
Cerebral Cavernous Malformation ◽  
Loss Of Function ◽  
Disease Pathogenesis ◽  
The Central Nervous System ◽  
The Impact

Cerebral cavernous malformation (CCM) is a disease characterized by mulberry shaped clusters of dilated microvessels, primarily in the central nervous system. Such lesions can cause seizures, headaches, and stroke from brain bleeding. Loss-of-function germline and somatic mutations of a group of genes, called CCM genes, have been attributed to disease pathogenesis. In this review, we discuss the impact of CCM gene encoded proteins on cellular signaling, barrier function of endothelium and epithelium, and their contribution to CCM and potentially other diseases.

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