Potentiometric determination of antihistaminic diphenhydramine hydrochloride in pharmaceutical preparations and biological fluids using screen-printed electrode

2011 ◽  
Vol 82 (2) ◽  
pp. 79-86 ◽  
Author(s):  
Eman Y.Z. Frag ◽  
Gehad G. Mohamed ◽  
Wael G. El-Sayed
Keyword(s):  
Biological Fluids ◽  
Pharmaceutical Preparations ◽  
Potentiometric Determination ◽  
Screen Printed Electrode ◽  
Diphenhydramine Hydrochloride ◽  
Screen Printed

scholarly journals Cost-Effective Potentiometric Platforms Modified with Multi-Walled Carbon Nanotubes (MWCNTs) and Based on Imprinted Receptors for Fluvoxamine Assessment

Polymers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 673
Author(s):  
Heba M. Hashem ◽  
Saad S. M. Hassan ◽  
Ayman H. Kamel ◽  
Abd El-Galil E. Amr ◽  
E. M. AbdelBary
Keyword(s):  
Carbon Nanotubes ◽  
Electrochemical Impedance ◽  
Biological Fluids ◽  
Pharmaceutical Preparations ◽  
Cost Effective ◽  
Hplc Method ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes ◽  
Screen Printed

A simple, efficient and reliable analytical method was developed and used for the determination of the fluvoxamine drug (FLV) in pharmaceutical preparations and biological fluids. The method is based on the cost-effective screen-printed platform for the potential transduction of the drug. Host-tailored molecular imprinting polymer (MIP) was integrated with the potentiometric platform as a recognition receptor, in which FLV, acrylamide (AAm), ethylene glycol dimethacrylate (EGDMA) and acetonitrile were used as a template, functional monomer, cross-linker, and solvent, respectively. MIP particles were dispersed in plasticized poly (vinyl chloride) (PVC) and the membrane was drop-casted on carbon screen-printed electrode. The MIP, in addition to non-imprinted polymers (NIP), was characterized and the binding experiment revealed high affinity and adsorption capacity of MIP towards FLV. The proposed sensor displayed near-Nernstian cationic slope of 55.0 ± 0.8 mV/decade (r2 = 0.999) with a low detection limit of 4.8 × 10−6 mol/L over a wide pH range (3.0–8.5). The electrochemical features of the proposed sensors including electrochemical impedance spectroscopy (EIS) and chronopotentiometry measurements (CP) in the presence of multi-walled carbon nanotubes (MWCNTs) as a solid contact transducer were also investigated. The applications of the proposed sensor for the determination of FLV in different dosage forms with recovery values (98.8%–101.9%) and (97.4%–101.1%), respectively compared with the reference HPLC method with acceptedFandt-student tests values at the 95% confidence level.

Modified Screen-Printed Ion Selective Electrodes for Potentiometric Determination of Sodium Dodecylsulfate in Different Samples

2015 ◽  
Vol 98 (1) ◽  
pp. 116-123 ◽  
Author(s):  
Tamer Awad Ali ◽  
Gehad G Mohamed
Keyword(s):  
Response Times ◽  
Inorganic Compounds ◽  
Cetylpyridinium Chloride ◽  
Sodium Dodecylsulfate ◽  
Direct Determination ◽  
Pharmaceutical Preparations ◽  
Ion Association ◽  
Potentiometric Determination ◽  
Screen Printed

Abstract Fabrication and general performance characteristics of novel screen-printed sensors for potentiometric determination of sodium dodecylsulfate (SDS) are described. The sensors are based on the use of ion-association complexes of SDS with cetylpyridinium chloride (electrode I) and cetyltrimethylammonium bromide (electrode II) as exchange sites in a screen-printed electrode matrix. Electrodes (I) and (II) show fast, stable, and near-Nernstian response for the mono-charge anion of SDS over the concentration range of1 × 10–2 – 5.8 × 10–7 and 1 × 10–2 – 6.3 × 10–7 mol/L at 25°C and the pH range of 2.0–9.0 and 2.0–8.0 with anionic slope of 57.32 ± 0.81 and 56.58 ± 0.65 mV/decade, respectively. Electrodes (I) and (II) have lower LODs of 5.8 × 10–7 and 6.3 × 10–7 mol/L and response times of about 8 and 13 s, respectively. Shelf life of5 months for both electrodes is adequate. Selectivity coefficients of SDS related to a number of interfering cations, and some inorganic compounds were investigated. There were negligible interferences causedby most of the investigated species. The direct determination of 0.10–13.50 mg of SDS by electrodes (I) and (II) shows average recoveries of 99.96 and 99.85%, and mean RSDs of 0.83 and 1.04%, respectively. In the present investigation, both electrodes were used successfully as end point indicators for determination of SDS in pure pharmaceutical preparations and real spiked water samples. The results obtained using the proposed sensors to determine SDS in solution compared favorably with those obtained by thestandard addition method.

scholarly journals Disposable gold nanoparticle functionalized and bare screen-printed electrodes for potentiometric determination of trazodone hydrochloride in pure form and pharmaceutical preparations

RSC Advances ◽  
2018 ◽  
Vol 8 (21) ◽  
pp. 11517-11527 ◽  
Author(s):  
Fathy M. Salama ◽  
Khalid A. Attia ◽  
Ragab A. Said ◽  
Ahmed El-Olemy ◽  
Ahmed M. Abdel-raoof
Keyword(s):  
Gold Nanoparticles ◽  
Gold Nanoparticle ◽  
Electrochemical Sensors ◽  
Pharmaceutical Preparations ◽  
Potentiometric Determination ◽  
Chemically Modified ◽  
Screen Printed Electrodes ◽  
Trazodone Hydrochloride ◽  
Screen Printed

In the present study, screen-printed electrodes unmodified and chemically modified with gold nanoparticles were used as sensitive electrochemical sensors for the determination of trazodone hydrochloride.

Voltammetric Determination of Diazepam on Antimony Film Screen-Printed Electrode in Pharmaceutical Formulations

2020 ◽  
Vol 16 ◽  
Author(s):  
Vesna Antunović ◽  
Rada Baošić ◽  
Aleksandar Lolić
Keyword(s):  
Modified Electrode ◽  
Limit Of Detection ◽  
Pharmaceutical Preparations ◽  
Ex Situ ◽  
Screen Printed Electrode ◽  
Limit Of Quantification ◽  
Azomethine Group ◽  
Antimony Film ◽  
Screen Printed

Background: Diazepam belongs to the group of 1,4-benzodiapines. It is used for the treatment of anxiety, convulsions and as a muscle relaxant. The presence of 4,5-azomethine group enables its electrochemical detection Introduction: A screen-printed electrode modified with antimony film was used for the determination of diazepam in pharmaceutical preparations Methods: Electrode modification was done by ex-situ deposition of antimony on commercially available screen-printed electrode. Parameters affecting the electroanalytical response of the sensor, such as deposition potential, deposition time, and antimony concentration, were examined and optimized. The modified electrode showed enhanced electroactivity for diazepam reduction compared to unmodified electrode. Under optimal conditions, linear sweep voltammetry was used for the determination of analyte Results: The sensor showed linear dependence in the range from 0.5 to 10 μmol/L, the correlation coefficient was 0.9992. The limit of detection was 0.33 μmol/L, corresponding limit of quantification was 1.08 μmol/L. Modification enabled determination of diazepam in the presence of oxygen. Conclusion: The modified electrode was used for the determination of diazepam in tablets. Results confirmed the applicability of the electrochemical sensor

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